DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and UGT3A2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_011512290.1	Gene:	UGT3A2 / 167127	HGNCID:	27266	Length:	550	Species:	Homo sapiens

Alignment Length:	562	Identity:	156/562 - (27%)
Similarity:	234/562 - (41%)	Gaps:	121/562 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LALLAFLLRPKP----NDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVAN 66
            |.|:.|||   |    ::||.||.: ...|.||:.....:...|.:.|||::|          .|
Human     7 LLLVGFLL---PGVLLSEAAKILTI-STVGGSHYLLMDRVSQILQDHGHNVTM----------LN 57

  Fly    67 YTDYVFQGMPLLTDI------------------VDLSNFESEWKPLGL-----------PFKVPT 102
            :....|  ||.|:|.                  ..|.:|:.|.|...:           .||...
Human    58 HKRGPF--MPGLSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSF 120

  Fly   103 YFMLHD-WGLR---------------SCKVALNSPLITQLLKSPIRYDVILLEHFSNDCMAAVAH 151
            .|.|.: .|.|               .|...||...|...||:. .:|::::|.| :.|...:|.
Human   121 DFFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNE-NFDMVIVETF-DYCPFLIAE 183

  Fly   152 LLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLP-----YTDEMSLIDRLNNFFHF------ 205
            .|..|.:|:.|.:.....:   |.|     :|::::|     .||.|....|:.||..|
Human   184 KLGKPFVAILSTSFGSLEF---GLP-----IPLSYVPVFRSLLTDHMDFWGRVKNFLMFFSFCRR 240

  Fly   206 --HTVNTLYNMITQPATDALIAERFGPGLPPI-NEIVKNTSLMLINQHYALTGPRPYAPNVIEVG 267
              |..:|.         |..|.|.|..|..|: :.::....|..||..:|....||..||.:.||
Human   241 QQHMQSTF---------DNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVG 296

  Fly   268 GLQVGPIKPLPQHLLDLLDR-SPNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMR-- 329
            ||...||||:||.|.:.:.: ..:|.:.::.|||||:...|.     :|      ||.|....
Human   297 GLMEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNTCQNPE-----IF------KEMNNAFAHL 350

  Fly   330 -----WKSLESLEDKQ---PSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVT 386
                 ||...|...|.   .:|:...|||||.|||.||.||.|::|||.....|||..||||:..
Human   351 PQGVIWKCQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGI 415

  Fly   387 PFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIIL-DKKFAERVRRSSEAFRQRPIPPIK 450
            |.:|||..|...|:.:.|||.:..:...:..:...::.|: ||::......:|...|..|:.|.:
Human   416 PLFGDQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQ 480

  Fly   451 LATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGI 492
            ....||:||::.|||.|::.......|.....:||.:|.||:
Human   481 RLVGWIDHVLQTGGATHLKPYVFQQPWHEQYLLDVFVFLLGL 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	147/538 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	133/493 (27%)
UGT3A2	XP_011512290.1	UDPGT	23..518	CDD:278624	146/537 (27%)
UGT3A2	XP_011512290.1	egt	<162..517	CDD:223071	114/384 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740