DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	574	Identity:	150/574 - (26%)
Similarity:	255/574 - (44%)	Gaps:	100/574 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLPLALL--AFL------------LRPKPNDAAHILG---LFQHPGKSHFDFFRPMFLALAERGH 50
            |||.|.|  .||            |...|.|.:|.|.   :.:|               |:||||
  Rat     4 LLPAARLPAGFLFLVLWGSVLGDKLLVVPQDGSHWLSMKEIVEH---------------LSERGH 53

  Fly    51 NISMYSYFPLEKPVAN-------YTDYVFQGMPLLTDIVDL--------SNFESEWKPLGLPFK- 99
            :|.:.      .|..|       |  |..:..|:..::.:|        :|..:...||..|.:
  Rat    54 DIVVL------VPEVNLLLGESKY--YRRKSFPVPYNLEELRTRYRSFGNNHFAASSPLMAPLRE 110

  Fly   100 VPTYFMLHDWGLRSCKVALNSPLITQLLKSPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCA 164
            .....::.|....||:..|........|:.. ::|.:..:. :..|...:|..|..|.:.|...
  Rat   111 YRNNMIVIDMCFFSCQSLLKDSATLSFLREN-QFDALFTDP-AMPCGVILAEYLKLPSVYLFRG- 172

  Fly   165 IMPWHYKRMGSPFINPI--MPMNFLPYTDEMSLIDRLNNF-------FHFHTVNTLYNMITQPAT 220
             .|...:.|.....:|:  :|..:..::|.|:...||.||       :.:|.:.:.|.::   |:
  Rat   173 -FPCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIANILENYLYHCLYSKYEIL---AS 233

  Fly   221 DALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLL 285
            |.|   :....||.:::    .||.|:...:....|||..||:|.:||........|.|.....:
  Rat   234 DLL---KRDVSLPALHQ----NSLWLLRYDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYV 291

  Fly   286 DRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDW 349
            :.| .:|::..|.||||:.  :|..|...:.:::.::.:   .:.|:...:.......|.....|
  Rat   292 NASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQ---TVLWRYTGTRPSNLAKNTILVKW 351

  Fly   350 LPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFD 414
            |||.|||.|||.||||:|.|..|..|.|..||||::.|.:|||..|:..::.||.||.::..:..
  Rat   352 LPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMT 416

  Fly   415 SNHITRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWI 478
            ::.:...|: :|.:|.:.|.:.|.|...:.|||.|:.||.:|:|:|:::.||||::..|..:.|.
  Rat   417 ADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWY 481

  Fly   479 VYNSIDVLLFWLGILFLLIVALRKLIKIFKTAF--CR------GKISRDTKTKT 524
            .|:|:||      |.|||.:.|..:..::|:..  ||      |::.:..|:||
  Rat   482 QYHSLDV------IGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	129/497 (26%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	115/449 (26%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	138/537 (26%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	140/542 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860