Protein Alignment Ugt36F1 and UGT2A1

DIOPT Version :9

• Sequence 1: NP_609909.1
• Gene: Ugt36F1 / 35137
• FlyBaseID: FBgn0027074
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 539
• Identity: 144/539 - (26%)
• Similarity: 242/539 - (44%)
• Gaps: 94/539 - (17%)

  Fly    33 SHFDFFRPMFLALAERGHNISM------------------YSYFPLEKPVANYTDYVFQGMPLL- 78
            ||:...:.:...|.:|.||:::                  :...|:....:| .|.:.:.|.:|
Human   241 SHWLNIKIILEELIQRNHNVTVLASSATLFINSNPDSPVNFEVIPVSYKKSN-IDSLIEHMIMLW 304

  Fly    79 -----TDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSP-LITQLLKSPIRYDVIL 137
                 |.:    ...:.:|.||.  .:.|:|.::   ::.|...|.:| |:.:|.|.  .:||::
Human   305 IDHRPTPL----TIWAFYKELGK--LLDTFFQIN---IQLCDGVLKNPKLMARLQKG--GFDVLV 358

  Fly   138 LEHFSNDCMAAVAHLLNAP---VIALSSCAIMPWHYKRMGSPFINPIMPMNFLPYTDEMSLIDRL 199
            .:..: .|...||..|..|   .:..|..:.:..|..::.:|.  ..:|......||:|:..:|:
Human   359 ADPVT-ICGDLVALKLGIPFMYTLRFSPASTVERHCGKIPAPV--SYVPAALSELTDQMTFGERI 420

  Fly   200 NNFFHFHTV-----------NTLYNMIT-QPATDALIAERFGPGLPPINEIVKNTSLMLINQHYA 252
            .|...:...           |:.|:.|. :|.|   :.|..|           ...:.||..::.
Human   421 KNTISYSLQDYIFQSYWGEWNSYYSKILGRPTT---LCETMG-----------KAEIWLIRTYWD 471

  Fly   253 LTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQ 316
            ...||||.||...||||...|.||||:.:.:.:..| .|||:..|.||||.:  |...|.:.:..
Human   472 FEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGKNGVVVFSLGSMVKN--LTEEKANLIAS 534

  Fly   317 SISQLKEYNFVMRWKSLESLEDKQP----SNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAI 377
            :::|:.:       |.|...:.|:|    :|...|||:||.|||.|||.:|||:|||..|..|||
Human   535 ALAQIPQ-------KVLWRYKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAI 592

  Fly   378 HCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK-KFAERVRRSSEAF 441
            :.||||:..|.:.||..|...:|.:|..|.|:.....|..:...||.:::: .:.|...|.|...
Human   593 YHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIH 657

  Fly   442 RQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIKI 506
            ..:|:.|:..|.:|||.|:::.||.|::..|..:.|..|:|:||      |.|||:.....:..:
Human   658 HDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDV------IGFLLVCVTTAIFLV 716

  Fly   507 FKTAF--CR--GKISRDTK 521
            .:...  |:  |||.:..|
Human   717 IQCCLFSCQKFGKIGKKKK 735

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	135/499 (27%)
		YjiC	38..461	CDD:224732	124/468 (26%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	139/527 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150093
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.740