DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36F1 and UGT2B11

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001064.1	Gene:	UGT2B11 / 10720	HGNCID:	12545	Length:	529	Species:	Homo sapiens

Alignment Length:	524	Identity:	133/524 - (25%)
Similarity:	236/524 - (45%)	Gaps:	68/524 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHFDFFRPMFLALAERGHNISM------------------YSYFPLEKPVANYTDYVFQGMPLLT 79
            ||:...:.:...|.:|||.:::                  :..:|.......:.:.:.|.:...:
Human    34 SHWMNMKTILKELVQRGHEVTVLASSASILFDPNDASTLKFEVYPTSLTKTEFENIIMQQVKRWS 98

  Fly    80 DIVDLSNFESEWKPLGLPFKVPTYFM--------LHDWGLRSCK-VALNSPLITQLLKSPIRYDV 135
            ||    ..:|.|          .||.        |:|.....|| |..|..::.:|.:|  |:|:
Human    99 DI----RKDSFW----------LYFSQEQEILWELYDIFRNFCKDVVSNKKVMKKLQES--RFDI 147

  Fly   136 ILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLP-----YTDEMSL 195
            :..:... .|...:|.|||  :..:.|....|.:.....|..:  |.|.:::|     .:|:|:.
Human   148 VFADAVF-PCGELLAALLN--IRFVYSLRFTPGYTIERHSGGL--IFPPSYIPIVMSKLSDQMTF 207

  Fly   196 IDRLNNFFHFHTVNTLYNMITQPATDALIAERFG-PGLPPINEIVKNTSLMLINQHYALTGPRPY 259
            ::|:.|..:....:..:.|......|...:|..| |  ..:.|.:....:.|:...::...|.|:
Human   208 MERVKNMIYVLYFDFWFQMSDMKKWDQFYSEVLGRP--TTLFETMGKADIWLMRNSWSFQFPHPF 270

  Fly   260 APNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKE 323
            .|||..|||....|.||||:.:.:.:..| .|||:..|.||::::.|  :.:.:.:..:::::.:
Human   271 LPNVDFVGGFHCKPAKPLPKEMEEFVQSSGENGVVVFSLGSVISNMT--AERANVIATALAKIPQ 333

  Fly   324 YNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPF 388
               .:.|:...:..|....|...:.|:||.|||.|||.||||:|||..|..|||:.|:||:..|.
Human   334 ---KVLWRFDGNKPDALGLNTRLYKWIPQNDLLGHPKTRAFITHGGANGIYEAIYHGIPMVGIPL 395

  Fly   389 YGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLA 452
            :.||..|...:|.:|..|.:||....|..:...|: :|.|..:.|.:.:.|.....:|:.|:..|
Human   396 FFDQPDNIAHMKAKGAAVRLDFNTMSSTDLLNALKTVINDPLYKENIMKLSRIQHDQPVKPLDRA 460

  Fly   453 TWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIKIFKTAFCRGKIS 517
            .:|||.|:.:.||.|::..|..:.|..|:|:||:.|.|..:..:|..:.|.     ..||..|.:
Human   461 VFWIEFVMPHKGAKHLRVAAHDLTWFQYHSLDVIGFLLACVATVIFIITKF-----CLFCFWKFA 520

  Fly   518 RDTK 521
            |..|
Human   521 RKGK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	124/488 (25%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	113/457 (25%)
UGT2B11	NP_001064.1	UDPGT	24..525	CDD:278624	133/524 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150143
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740