DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF254

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_975011.3	Gene:	ZNF254 / 9534	HGNCID:	13047	Length:	659	Species:	Homo sapiens

Alignment Length:	741	Identity:	154/741 - (20%)
Similarity:	247/741 - (33%)	Gaps:	273/741 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 SGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQ 373
            |.||:..:|:..:.:.:   .||..::.. .:|:...||:  ...|:.:.....|.::..|.||:
Human   128 SVDEYKVNKEGYNGLNQ---CFTTAQSKV-FQCDKYLKVF--YKFLNSNRPKIRHTEKKSFKCKK 186

  Fly   374 CALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAY------------------ 420
            ....||......:|::|.|.. :.|.|:.|.|.|...|.|..|.:.|
Human   187 RVKLFCMLSHKTQHKSIYHRE-KSYKCKECGKTFNWSSTLTNHRKIYTEEKPYKCEEYNKSPKQL 250

  Fly   421 ---------HVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRM 476
                     |.|.:.:.|.|||:.|..||.|..|:.||:..||:.||.|.||:...|.|..||::
Human   251 STLTTHEIIHAGEKLYKCEECGEAFNRSSNLTTHKIIHTGEKPYKCEECGKAFIWSSTLTEHKKI 315

  Fly   477 HATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATA 541
            | |.:...||::|.::|...::||:||:.  .||..||:
Human   316 H-TRKKPYKCEECGKAFIWSSTLTRHKRM--HTGEKPYK-------------------------- 351

  Fly   542 TSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNI 606
               |....:..|:||:                                      |..:.:..|.
Human   352 ---CEECGKAFSQSST--------------------------------------LTTHKIIHTG- 374

  Fly   607 PMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPL 671
                .|....|.||        .||.|                ...:|..:::...|:..|.|..
Human   375 ----EKRYKCLECG--------KAFKQ----------------LSTLTTHKIIHVGEKLYKCEEC 411

  Fly   672 VQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPP 736
            .:.|      :|||.....|:..|
Human   412 GKGF------NRSSNLTTHKIIHT----------------------------------------- 429

  Fly   737 PADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHS---- 797
                   |:.|.....|.|....|       ..|..|:   |:|    .|.:|.|..:...
Human   430 -------GEKPYKCEECGKAFIWS-------STLTKHK---RIH----TREKPYKCEECGKAFIW 473

  Fly   798 SAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALA 862
            |:..:..::.|.|..|...              ...|...|.:|
Human   474 SSTLTRHKRMHTGEKPYKC--------------EECGKSFSQSS--------------------- 503

  Fly   863 SGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVV 927
               ||     |.|.:    |:....|:.|:..|:       |...|:...|..:
Human   504 ---TL-----TTHKI----IHTGEKPYKCEECGK-------AFNWSSTLTKHKI----------- 538

  Fly   928 GLKTKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERP 991
             :.|::: |.|:.|||.|.:|:.||.|.|.||||:||.|:.|.::|:.||...:| :.||...:|
Human   539 -IHTEEKPYKCEKCGKAFKQSSILTNHKRIHTGEKPYKCEECGKSFNRSSTFTKH-KVIHTGVKP 601

  Fly   992 FRCELCDRSFGQQTNLDRHVKKHESE 1017
            ::||.|.::|...:.|.:|.:.|..|
Human   602 YKCEECGKAFFWSSTLTKHKRIHTGE 627

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	4/21 (19%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	35/114 (31%)
		C2H2 Zn finger	400..421	CDD:275368	8/47 (17%)
		SUF4-like	403..>445	CDD:411020	17/68 (25%)
		C2H2 Zn finger	403..421	CDD:411020	7/44 (16%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	10/86 (12%)
		COG5048	935..>1028	CDD:227381	34/83 (41%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	6/20 (30%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF254	NP_975011.3	KRAB	13..73	CDD:214630
		C2H2 Zn finger	184..204	CDD:275368	5/19 (26%)
		C2H2 Zn finger	212..260	CDD:275368	8/47 (17%)
		COG5048	264..625	CDD:227381	122/594 (21%)
		C2H2 Zn finger	268..288	CDD:275368	9/19 (47%)
		C2H2 Zn finger	296..316	CDD:275368	9/19 (47%)
		C2H2 Zn finger	324..344	CDD:275368	7/21 (33%)
		C2H2 Zn finger	352..372	CDD:275368	5/57 (9%)
		C2H2 Zn finger	380..400	CDD:275368	7/43 (16%)
		C2H2 Zn finger	408..428	CDD:275368	6/25 (24%)
		C2H2 Zn finger	436..456	CDD:275368	6/29 (21%)
		C2H2 Zn finger	464..484	CDD:275368	1/19 (5%)
		C2H2 Zn finger	492..512	CDD:275368	7/66 (11%)
		C2H2 Zn finger	520..540	CDD:275368	5/38 (13%)
		C2H2 Zn finger	548..568	CDD:275368	10/19 (53%)
		C2H2 Zn finger	576..596	CDD:275368	6/20 (30%)
		C2H2 Zn finger	604..624	CDD:275368	6/19 (32%)
		C2H2 Zn finger	632..652	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000