DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF486

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_443084.2	Gene:	ZNF486 / 90649	HGNCID:	20807	Length:	463	Species:	Homo sapiens

Alignment Length:	445	Identity:	108/445 - (24%)
Similarity:	168/445 - (37%)	Gaps:	110/445 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 EWVRRREPVC---------ELDIRDSGGVYAKTPLQRGTR--YGPFPMKLSHQPNDPQLAWKAHS 188
            |.:.:...||         |..|:||   |.|..|::..:  :|....|...:..|   ..|.|.
Human    78 EMIAKPPVVCSHFAQDLWPEQSIKDS---YQKVILRKFEKCGHGNLHFKKGCESVD---ECKLHK 136

  Fly   189 RHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSP 253
            |.|||.   .:.::|...||          .....|:...:.:..:.|:....:|       |.|
Human   137 RGYNGL---NQCLTTTQSKI----------FQCGKYVKVFHQFSNSKRHKRRHTE-------KKP 181

  Fly   254 VQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSL-YSGDEFSKDK 317
            ::    ::.|.|..                       ..|:........|.|.. |..:|..|..
Human   182 LK----YIEGDKAF-----------------------NQSSTHTTHKKIDTGEKPYKCEECGKAF 219

  Fly   318 KNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDH-----------------------LI 359
            ..||.:....|..|.::   ..:||.|.||:........|                       .:
Human   220 NRSSHLTTHKITHTREK---PYKCEECGKVFKYFSSFTTHKKIHSGEKPYICEECGKAFMYPYTL 281

  Fly   360 GAH---HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYH 421
            ..|   |..:..:.||:|...|.|...|..|:.| |...:.|:|:.|.|.|...|.|.:| ...|
Human   282 TTHKIIHTGEQPYKCKECDKAFNHPATLSSHKKI-HTGEKPYTCDKCGKAFISSSILSKH-EKIH 344

  Fly   422 VGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKC 486
            .|.:.:.|.||||.|..||.|..|:.||:..||:.||.|.||:|..:.|.:|:|.| |.....||
Human   345 TGEKPYKCEECGKAFTRSSHLTMHKIIHTGEKPYKCEECGKAFTWSAGLHKHRRTH-TGEKPYKC 408

  Fly   487 DKCNQSFSTLTSLTKHKKFCDSTGPGPYR----------NQHVNRHHQ-HPHQHP 530
            ::|.::::|.::||:||  ...||..||:          :..:|:|.: |..|.|
Human   409 EECGKAYTTSSNLTEHK--TTHTGEKPYKCKECGKAFNWSSDLNKHKRIHIGQKP 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	26/128 (20%)
		C2H2 Zn finger	341..363	CDD:275368	7/47 (15%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412
		COG5048	935..>1028	CDD:227381
		zf-C2H2	935..957	CDD:395048
		C2H2 Zn finger	937..957	CDD:275368
		zf-H2C2_2	949..973	CDD:404364
		C2H2 Zn finger	965..986	CDD:275368
		C2H2 Zn finger	994..1014	CDD:275368
ZNF486	NP_443084.2	KRAB	13..71	CDD:214630
		KRAB	15..52	CDD:279668
		C2H2 Zn finger	155..176	CDD:275368	2/20 (10%)
		COG5048	188..>463	CDD:227381	80/305 (26%)
		C2H2 Zn finger	188..204	CDD:275368	2/38 (5%)
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		zf-H2C2_2	224..249	CDD:290200	7/27 (26%)
		C2H2 Zn finger	240..260	CDD:275368	6/19 (32%)
		C2H2 Zn finger	268..288	CDD:275368	1/19 (5%)
		zf-H2C2_2	281..305	CDD:290200	6/23 (26%)
		C2H2 Zn finger	296..316	CDD:275368	8/20 (40%)
		zf-H2C2_2	309..333	CDD:290200	9/24 (38%)
		C2H2 Zn finger	324..344	CDD:275368	7/20 (35%)
		zf-H2C2_2	337..361	CDD:290200	10/24 (42%)
		C2H2 Zn finger	352..372	CDD:275368	10/19 (53%)
		zf-H2C2_2	364..388	CDD:290200	11/23 (48%)
		C2H2 Zn finger	380..400	CDD:275368	9/19 (47%)
		zf-H2C2_2	395..417	CDD:290200	7/22 (32%)
		C2H2 Zn finger	408..428	CDD:275368	7/21 (33%)
		zf-H2C2_2	420..444	CDD:290200	8/25 (32%)
		C2H2 Zn finger	436..456	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000