DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF628

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_149104.3	Gene:	ZNF628 / 89887	HGNCID:	28054	Length:	1059	Species:	Homo sapiens

Alignment Length:	821	Identity:	193/821 - (23%)
Similarity:	295/821 - (35%)	Gaps:	266/821 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 MNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIRE 325
            |:|  |:..:.|..|....|..:|.|.   |.:||:.       .:.|...|..|..:.||.:..
Human     1 MSG--VMVGSHADMAPASTAEGAGEKP---GPAAPAP-------AAQYECGECGKSFRWSSRLLH 53

  Fly   326 GDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAI 390
            .....|.:.   ..:|..|.|.:.....|..|..|  |..:..:.|..|...|....||..|.::
Human    54 HQRTHTGER---PYKCPDCPKAFKGSSALLYHQRG--HTGERPYQCPDCPKAFKRSSLLQIHRSV 113

  Fly   391 SHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPF 455
             |..:|.:.|..|...|...|:.|.|:| .|.|.|.:|||:|.|.|..||.|::|:|:|:..:|:
Human   114 -HTGLRAFICGQCGLAFKWSSHYQYHLR-QHTGERPYPCPDCPKAFKNSSSLRRHRHVHTGERPY 176

  Fly   456 ACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF--------CDSTGPG 512
            .|.||.|::||.:||.:|:|:| |.....:|..|.::|:..::|..|::.        ..|..|.
Human   177 TCGVCGKSFTQSTNLRQHQRVH-TGERPFRCPLCPKTFTHSSNLLLHQRTHGAAPAPGTASAAPP 240

  Fly   513 PYRNQ---------HVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMS 568
            |...:         ::.||.|       ||.|          ||||                  :
Human   241 PQSREPGKVFVCDAYLQRHLQ-------PHSP----------PAPP------------------A 270

  Fly   569 TPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPL--HPTNIPMFFSKNPMDLGCGGPEITSPVSAF 631
            .||.|                   ||.:|:..|  ..|.:.:.:.       |.|.|
Human   271 PPPPP-------------------PPVVPELFLAAAETTVELVYR-------CDGCE-------- 301

  Fly   632 DQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTR 696
                     :|.:||          ||:      |:.:|.
Human   302 ---------QGFSSE----------ELL------LEHQPC------------------------- 316

  Fly   697 NDSKSEEQDDMKQEPERVSTPDQQQAE---DDRKSIDIMSTPPPADTPSGGDGPLDLSICRK--R 756
                        ..|:....|.:..||   .|:....:...||||..|:.|...|.   |.|  |
Human   317 ------------PGPDAAPQPQEAPAEAPKADQPPSPLPQPPPPAAAPAPGFACLP---CGKSFR 366

  Fly   757 SA------------------------GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHS 797
            :.                        |||   |...:|:.|:   :.|..||..|:|....:
Human   367 TVAGLSRHQHSHGAAGGQAFRCGSCDGSF---PQLASLLAHQ---QCHVEEAAAGRPPPQAE--- 422

  Fly   798 SAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAF-AADHSAL 861
            :||.:..|:        |...|:|...|.||.|.||.........|.:....:...: ..||:.
Human   423 AAEVTCPQE--------PLAPAAPVPPPPPSAPASAERPYKCAECGKSFKGSSGLRYHLRDHTG- 478

  Fly   862 ASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR------------GIEALLAGAASAAAPKR 914
                              |..|:.|   .|....:|            |:.|...|.....
Human   479 ------------------ERPYQCG---ECGKAFKRSSLLAIHQRVHTGLRAFTCGQCGLT---- 518

  Fly   915 PLPPVKFSAGSVVGLK--TKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISS 976
                .|:|:.....|:  :.:| |:|..|||.|..::.|.||...||||:|:.|..|.::|:.:|
Human   519 ----FKWSSHYQYHLRLHSGERPYACGECGKAFRNTSCLRRHRHVHTGERPHACGVCGKSFAQTS 579

  Fly   977 NLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ||::|.| :|..||||||.||.::|...:||..|.:.|.:|
Human   580 NLRQHQR-VHTGERPFRCPLCPKTFTHSSNLLLHQRTHSAE 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	12/89 (13%)
		COG5048	935..>1028	CDD:227381	37/83 (45%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF628	NP_149104.3	C2H2 Zn finger	38..58	CDD:275368	4/19 (21%)
		COG5048	<43..213	CDD:227381	56/177 (32%)
		C2H2 Zn finger	66..86	CDD:275368	6/21 (29%)
		C2H2 Zn finger	94..114	CDD:275368	6/20 (30%)
		C2H2 Zn finger	122..142	CDD:275368	7/20 (35%)
		C2H2 Zn finger	150..170	CDD:275368	10/19 (53%)
		C2H2 Zn finger	178..198	CDD:275368	10/19 (53%)
		zf-C2H2	204..226	CDD:306579	5/21 (24%)
		C2H2 Zn finger	206..226	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247		3/20 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..280		13/73 (18%)
		C2H2 Zn finger	297..314	CDD:275368	9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..351		10/75 (13%)
		C2H2 Zn finger	361..378	CDD:275370	3/16 (19%)
		C2H2 Zn finger	388..408	CDD:275368	6/25 (24%)
		COG5048	<453..642	CDD:227381	52/198 (26%)
		C2H2 Zn finger	456..476	CDD:275368	1/19 (5%)
		C2H2 Zn finger	484..504	CDD:275368	3/22 (14%)
		C2H2 Zn finger	512..532	CDD:275368	4/27 (15%)
		C2H2 Zn finger	540..560	CDD:275368	8/19 (42%)
		C2H2 Zn finger	568..588	CDD:275368	8/20 (40%)
		C2H2 Zn finger	596..616	CDD:275368	7/19 (37%)
		C2H2 Zn finger	624..644	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..674
		4 X approximate tandem repeats. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	818..864
		Interaction with TAF4B. /evidence=ECO:0000250\|UniProtKB:Q8CJ78	943..1059
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910