DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF587

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_116217.1	Gene:	ZNF587 / 84914	HGNCID:	30955	Length:	575	Species:	Homo sapiens

Alignment Length:	718	Identity:	132/718 - (18%)
Similarity:	191/718 - (26%)	Gaps:	336/718 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 EFSKDKKNSSLI--REGDIDFTD---------DENGFDIRCEVCDKVYPDLDLLDDHLIGAHH-- 363
            ||.||...||.:  .|..::.||         .|...:..|....|.:.     ..|.:..|.
Human   174 EFGKDVLPSSGLCQEEAAVEKTDSETMHGPPFQEGKTNYSCGKRTKAFS-----TKHSVIPHQKL 233

  Fly   364 FKQDE-FPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |.:|. :.|..|...|........|:. .|.....|.|..|.|.:...|:|.:|.|. |.|...:
Human   234 FTRDGCYVCSDCGKSFSRYVSFSNHQR-DHTAKGPYDCGECGKSYSRKSSLIQHQRV-HTGQTAY 296

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            ||.||||:|.....|..||.:|:...|:.|..|.|::.|..||.:|::.| |......|.:|.:|
Human   297 PCEECGKSFSQKGSLISHQLVHTGEGPYECRECGKSFGQKGNLIQHQQGH-TGERAYHCGECGKS 360

  Fly   493 FSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            |        .:|||           .:|  ||..|....|::
Human   361 F--------RQKFC-----------FIN--HQRVHTGERPYK----------------------- 381

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
                                                                         ||
Human   382 -------------------------------------------------------------CG-- 383

  Fly   623 EITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLD 687
                                                                      |...|..
Human   384 ----------------------------------------------------------ECGKSFG 390

  Fly   688 IKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSI 752
            .||.|                ...:|..|                           |:.|.:...
Human   391 QKGNL----------------VHHQRGHT---------------------------GERPYECKE 412

  Fly   753 CRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTP 817
            |.|    ||            |:...|.|                      .|:.|.|..|
Human   413 CGK----SF------------RYRSHLTE----------------------HQRLHTGERP---- 435

  Fly   818 TASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEI 882
                                .:..|.|.:                       .:..:|.|:.|.:
Human   436 --------------------YNCRECGKL-----------------------FNRKYHLLVHERV 457

  Fly   883 YRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPR 946
            :....|:.|:..|:     |.....|....:|              :.|.:| |.|..|||.|..
Human   458 HTGERPYACEVCGK-----LFGNKHSVTIHQR--------------IHTGERPYECSECGKSFLS 503

  Fly   947 SANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHV 1011
            |:.|..|.|.|:|::||.|..|.::||..|:|.:| |.||..|||:.|..|.::|.:.:.|..|.
Human   504 SSALHVHKRVHSGQKPYKCSECGKSFSECSSLIKH-RRIHTGERPYECTKCGKTFQRSSTLLHHQ 567

  Fly  1012 KKH 1014
            ..|
Human   568 SSH 570

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	3/21 (14%)
		C2H2 Zn finger	371..392	CDD:275368	4/20 (20%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	4/17 (24%)
		PTZ00121	<641..>728	CDD:173412	7/86 (8%)
		COG5048	935..>1028	CDD:227381	33/80 (41%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	9/23 (39%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF587	NP_116217.1	KRAB	15..70	CDD:214630
		KRAB	15..54	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	69..88
		C2H2 Zn finger	94..114	CDD:275368
		C2H2 Zn finger	122..142	CDD:275368
		C2H2 Zn finger	242..262	CDD:275368	4/20 (20%)
		C2H2 Zn finger	270..290	CDD:275368	7/20 (35%)
		COG5048	<273..568	CDD:227381	108/609 (18%)
		C2H2 Zn finger	298..318	CDD:275368	9/19 (47%)
		C2H2 Zn finger	326..343	CDD:275368	6/16 (38%)
		C2H2 Zn finger	354..374	CDD:275368	10/40 (25%)
		zf-H2C2_2	369..389	CDD:290200	8/165 (5%)
		C2H2 Zn finger	382..402	CDD:275368	8/95 (8%)
		zf-H2C2_2	394..419	CDD:290200	9/83 (11%)
		C2H2 Zn finger	410..430	CDD:275368	8/57 (14%)
		zf-H2C2_2	422..447	CDD:290200	8/93 (9%)
		C2H2 Zn finger	438..458	CDD:275368	5/42 (12%)
		zf-H2C2_2	450..473	CDD:290200	6/27 (22%)
		C2H2 Zn finger	466..486	CDD:275368	5/38 (13%)
		zf-H2C2_2	478..503	CDD:290200	10/38 (26%)
		C2H2 Zn finger	494..514	CDD:275368	9/19 (47%)
		zf-H2C2_2	509..530	CDD:290200	8/20 (40%)
		C2H2 Zn finger	522..542	CDD:275368	8/20 (40%)
		zf-H2C2_2	534..557	CDD:290200	10/23 (43%)
		C2H2 Zn finger	550..570	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910