DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF607

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_116078.4 Gene:ZNF607 / 84775 HGNCID:28192 Length:696 Species:Homo sapiens


Alignment Length:705 Identity:158/705 - (22%)
Similarity:234/705 - (33%) Gaps:255/705 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   341 CEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRF-CHRPLLIKHEAISHNNIRKYSCENCS 404
            ||.|.||:.....|..|  |..|.:: .:.||:|...| ..|.|.:.|.  .|...:.|.|:.|.
Human   172 CEECGKVFSYPANLAQH--GKVHVEK-PYECKECGEAFRTSRQLTVHHR--FHYGEKPYECKECG 231

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|.....|.|| ::.|.|.:...|.:|||:|...:|||.||.||:..||..|:.|.||:.|||:
Human   232 KAFSVYGRLSRH-QSIHTGEKPFECNKCGKSFRLKAGLKVHQSIHTGEKPHECKECGKAFRQFSH 295

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQ 534
            |..|||:| |.....:|.:|.:.|:....||.|::.        |..:   :|::          
Human   296 LVGHKRIH-TGEKPYECKECGKGFTCRYQLTMHQRI--------YSGE---KHYE---------- 338

  Fly   535 PHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQN 599
                      |    :|:.|:.||                                         
Human   339 ----------C----KENGEAFSS----------------------------------------- 348

  Fly   600 PLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEE 664
                                 |.::|:|.:....:.|:              |..|....|....
Human   349 ---------------------GHQLTAPHTFESVEKPY--------------KCEECGKAFSVHG 378

  Fly   665 KLKKEPLVQA----FE----GEEDESRSSLDIKGKLEDTRNDSKSEE------QDDMKQEPERVS 715
            :|.:...:.:    :|    |:.....|||.|...:.......|.:|      |........|:.
Human   379 RLTRHQGIHSGKKPYECNKCGKSFRLNSSLKIHQNIHTGEKPYKCKECGKAFSQRAHLAHHNRIH 443

  Fly   716 TPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLH 780
            |                           |..|.:...|.|    ||..|   ..|::|.   |:|
Human   444 T---------------------------GYKPFECKECGK----SFRCA---SYLVIHE---RIH 471

  Fly   781 EFE-----AERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSST 840
            ..|     .|.|:....  ||   :.:..::.|.|..|..........        |..|:|:  
Human   472 TGEKPYVCQECGKGFSY--SH---KLTIHRRVHTGEKPYECKECGKAF--------SVSGQLT-- 521

  Fly   841 SEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGR--RGIEALL 903
                            .|.::.||..                     ||.|...|:  |.|..|.
Human   522 ----------------QHLSIHSGKK---------------------PFECNKCGKSFRFISVLK 549

  Fly   904 A--GAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCK 966
            |  ...||..|                      |.||.|||.|..:.:|..|.|||.||:.|.||
Human   550 AHQNIHSAEKP----------------------YECKECGKAFRHATSLIYHDRTHAGEKSYECK 592

  Fly   967 YCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNF 1021
            .|...||.:|:|..|.| ||..::|:.|:.|.::|...:.|.||...| ::||.:
Human   593 ECGETFSHASHLIIHER-IHTSDKPYECKRCGKAFHCASYLVRHESVH-ADGNPY 645

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 8/21 (38%)
C2H2 Zn finger 371..392 CDD:275368 7/21 (33%)
SFP1 <391..479 CDD:227516 37/87 (43%)
C2H2 Zn finger 400..421 CDD:275368 7/20 (35%)
SUF4-like 403..>445 CDD:411020 16/41 (39%)
C2H2 Zn finger 403..421 CDD:411020 6/17 (35%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 11/19 (58%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 15/100 (15%)
COG5048 935..>1028 CDD:227381 36/87 (41%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 6/19 (32%)
ZNF607NP_116078.4 KRAB 7..67 CDD:214630
KRAB 7..45 CDD:279668
C2H2 Zn finger 116..136 CDD:275368
C2H2 Zn finger 144..164 CDD:275368
C2H2 Zn finger 172..192 CDD:275368 8/21 (38%)
C2H2 Zn finger 199..219 CDD:275368 7/21 (33%)
C2H2 Zn finger 227..247 CDD:275368 7/20 (35%)
zf-H2C2_2 240..262 CDD:290200 9/22 (41%)
C2H2 Zn finger 255..275 CDD:275368 10/19 (53%)
zf-H2C2_2 268..292 CDD:290200 12/23 (52%)
COG5048 279..687 CDD:227381 119/592 (20%)
C2H2 Zn finger 283..303 CDD:275368 11/19 (58%)
zf-H2C2_2 295..320 CDD:290200 9/25 (36%)
C2H2 Zn finger 311..330 CDD:275368 6/18 (33%)
C2H2 Zn finger 367..387 CDD:275368 3/19 (16%)
C2H2 Zn finger 395..415 CDD:275368 5/19 (26%)
zf-H2C2_2 407..432 CDD:290200 5/24 (21%)
C2H2 Zn finger 423..443 CDD:275368 3/19 (16%)
C2H2 Zn finger 451..471 CDD:275368 8/29 (28%)
zf-H2C2_2 463..488 CDD:290200 7/27 (26%)
C2H2 Zn finger 479..499 CDD:275368 4/24 (17%)
zf-H2C2_2 492..515 CDD:290200 3/30 (10%)
C2H2 Zn finger 507..527 CDD:275368 4/45 (9%)
C2H2 Zn finger 535..555 CDD:275368 6/19 (32%)
C2H2 Zn finger 563..583 CDD:275368 9/19 (47%)
C2H2 Zn finger 591..611 CDD:275368 9/20 (45%)
C2H2 Zn finger 619..639 CDD:275368 6/19 (32%)
C2H2 Zn finger 647..667 CDD:275368
C2H2 Zn finger 675..695 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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