DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF528

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_006723481.1	Gene:	ZNF528 / 84436	HGNCID:	29384	Length:	712	Species:	Homo sapiens

Alignment Length:	680	Identity:	140/680 - (20%)
Similarity:	206/680 - (30%)	Gaps:	284/680 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |.::..:.|.:....|  |........:.||....|.|..|.|||...|.|..| |..|.|.:.:
Human   264 HIREKAYKCNEHGQVF--RASASLTNQVIHNADNPYKCSECGKVFSCSSKLVIH-RRMHTGEKPY 325

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.||||.|.::|.|.|||.||:..||:.|..|.|.:...|.|.:|:|:| |.....||.:|::.
Human   326 KCHECGKLFSSNSNLSQHQRIHTGEKPYKCHECDKVFRSSSKLAQHQRIH-TGEKPYKCHECDKV 389

  Fly   493 FSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            |:.:..|.:|:|.  .||..||                             :|..
Human   390 FNQIAHLVRHQKI--HTGEKPY-----------------------------SCNK---------- 413

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
                                                                         ||
Human   414 -------------------------------------------------------------CG-- 415

  Fly   623 EITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLD 687
                  ..|.:                :..:.|.:.|...|:..|.|...:||     ..||||.
Human   416 ------KVFSR----------------HSYLAEHQTVHTGEKPYKCEECGKAF-----SVRSSLI 453

  Fly   688 IKGKLEDTRNDSKSEEQDDM------KQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDG 746
            ....:...|...|.:|.|.:      ....:|:.|.::
Human   454 THQLIHTGRKPYKCKECDKVFGRKCFLTSHQRIHTRER--------------------------- 491

  Fly   747 PLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGS 811
            |...|.|     |..|                     :::...::.||:|      |.:|.:|.:
Human   492 PYGCSQC-----GKIF---------------------SQKSDLIRHRKTH------TDEKPYKCN 524

  Fly   812 SPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHP 876
            .                                     ...||.                 .|..
Human   525 K-------------------------------------CGTAFR-----------------EFSD 535

  Fly   877 LLLEEIYRSG-FPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKF 939
            |....:..|| .|:.|:..|:                   :...|.|..|...:.|.:: |.|..
Human   536 LTAHFLIHSGEKPYECKECGK-------------------VFRYKSSLTSHHRIHTGEKPYKCNR 581

  Fly   940 CGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQ 1004
            |||||.||:||..|.:.||||:||.|..|.:.|:.:|.|.|| :.||..|||:||..|.::|...
Human   582 CGKVFSRSSNLVCHQKIHTGEKPYKCNQCGKVFNQASYLTRH-QIIHTGERPYRCSKCGKAFRGC 645

  Fly  1005 TNLDRHV------KKHESE--GNNFRDSPS 1026
            :.|..|:      |.||.:  |..|....|
Human   646 SGLTAHLAIHTEKKSHECKECGKIFTQKSS 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	140/680 (21%)
		C2H2 Zn finger	371..392	CDD:275368	3/20 (15%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	17/92 (18%)
		COG5048	935..>1028	CDD:227381	42/100 (42%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	6/25 (24%)
ZNF528	XP_006723481.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	272..291	CDD:275368	3/20 (15%)
		COG5048	277..712	CDD:227381	138/667 (21%)
		C2H2 Zn finger	299..319	CDD:275368	9/20 (45%)
		zf-H2C2_2	312..336	CDD:290200	11/24 (46%)
		C2H2 Zn finger	327..347	CDD:275368	11/19 (58%)
		zf-H2C2_2	339..364	CDD:290200	11/24 (46%)
		C2H2 Zn finger	355..375	CDD:275368	7/19 (37%)
		zf-H2C2_2	368..392	CDD:290200	9/24 (38%)
		C2H2 Zn finger	383..403	CDD:275368	6/21 (29%)
		zf-H2C2_2	395..420	CDD:290200	11/134 (8%)
		C2H2 Zn finger	411..431	CDD:275368	5/114 (4%)
		zf-H2C2_2	423..447	CDD:290200	7/28 (25%)
		C2H2 Zn finger	439..459	CDD:275368	7/24 (29%)
		C2H2 Zn finger	467..487	CDD:275368	3/19 (16%)
		C2H2 Zn finger	495..515	CDD:275368	6/45 (13%)
		C2H2 Zn finger	523..543	CDD:275368	4/73 (5%)
		zf-H2C2_2	535..560	CDD:290200	6/43 (14%)
		C2H2 Zn finger	551..571	CDD:275368	5/38 (13%)
		zf-H2C2_2	563..588	CDD:290200	10/24 (42%)
		C2H2 Zn finger	579..599	CDD:275368	11/19 (58%)
		zf-H2C2_2	591..616	CDD:290200	12/24 (50%)
		C2H2 Zn finger	607..627	CDD:275368	7/20 (35%)
		zf-H2C2_2	619..642	CDD:290200	11/23 (48%)
		C2H2 Zn finger	635..655	CDD:275368	5/19 (26%)
		C2H2 Zn finger	663..683	CDD:275368	3/13 (23%)
		zf-H2C2_2	675..700	CDD:290200	1/1 (100%)
		C2H2 Zn finger	691..711	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910