DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF430

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_079465.3 Gene:ZNF430 / 80264 HGNCID:20808 Length:570 Species:Homo sapiens


Alignment Length:646 Identity:134/646 - (20%)
Similarity:199/646 - (30%) Gaps:289/646 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |..:..|.||:|...||....|.:|:.| |.....|.||.|.|||...|.|.|| |..|.|.:.:
Human   199 HTGKKPFKCKKCDKSFCMLLHLTQHKRI-HIRENSYQCEECGKVFNWFSTLTRH-RRIHTGEKPY 261

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.:|||.|..||.|..|:.||:..||:.||.|.|.:.:.|:|..|||:| |.....:|::|.::
Human   262 KCEQCGKAFKQSSTLTTHKIIHTGEKPYRCEECGKTFNRSSHLTTHKRIH-TGEKPYRCEECGRA 325

  Fly   493 FSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSS 557
            |:..:.||.||..  .||..||:.:.                                       
Human   326 FNRSSHLTTHKII--HTGEKPYKCEE--------------------------------------- 349

  Fly   558 SAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGP 622
                                                                         ||  
Human   350 -------------------------------------------------------------CG-- 351

  Fly   623 EITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLD 687
                  .||:|.                ..:|..:::...|:..|.|...:||      .|.|..
Human   352 ------KAFNQS----------------STLTTHKIIHAGEKPYKCEECGKAF------YRFSYL 388

  Fly   688 IKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQ-QQAEDDRKSIDIMSTPPPADTPSGGDGPLDLS 751
            .|.|:                     :.|.:: .:.|:..|..:..||                 
Human   389 TKHKI---------------------IHTGEKFYKCEECGKGFNWSST----------------- 415

  Fly   752 ICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPT 816
                              |..|:   |:|..|    :|.|..:...:...|::..:||       
Human   416 ------------------LTKHK---RIHTGE----KPYKCEQCGKAFNESSNLTAHK------- 448

  Fly   817 PTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEE 881
                                :..|.|.                                      
Human   449 --------------------IIHTGEK-------------------------------------- 455

  Fly   882 IYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPR 946
                  |:.|:..|:             |..:.|    |.:|..|:....|. |.|:.|||.|.:
Human   456 ------PYKCEECGK-------------AFNRSP----KLTAHKVIHSGEKP-YKCEECGKAFNQ 496

  Fly   947 SANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNL 1007
            .:|||:|..||.|:..|....||:|||.||.|.:| :.||..|:|:.||...::|.|.:||
Human   497 FSNLTKHKITHIGDTSYKYLECDKAFSQSSTLTKH-KVIHTGEKPYNCEEYGKAFNQSSNL 556

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 134/646 (21%)
C2H2 Zn finger 371..392 CDD:275368 8/20 (40%)
SFP1 <391..479 CDD:227516 38/87 (44%)
C2H2 Zn finger 400..421 CDD:275368 11/20 (55%)
SUF4-like 403..>445 CDD:411020 19/41 (46%)
C2H2 Zn finger 403..421 CDD:411020 9/17 (53%)
C2H2 Zn finger 429..449 CDD:275368 9/19 (47%)
C2H2 Zn finger 457..477 CDD:275368 9/19 (47%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 12/87 (14%)
COG5048 935..>1028 CDD:227381 33/73 (45%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 6/14 (43%)
ZNF430NP_079465.3 KRAB 35..96 CDD:214630
KRAB 35..74 CDD:279668
COG5048 202..562 CDD:227381 133/643 (21%)
C2H2 Zn finger 207..227 CDD:275368 8/20 (40%)
C2H2 Zn finger 235..255 CDD:275368 11/20 (55%)
zf-H2C2_2 248..272 CDD:290200 11/24 (46%)
C2H2 Zn finger 263..283 CDD:275368 9/19 (47%)
zf-H2C2_2 276..300 CDD:290200 10/23 (43%)
C2H2 Zn finger 291..311 CDD:275368 9/19 (47%)
zf-H2C2_2 303..328 CDD:290200 9/25 (36%)
C2H2 Zn finger 319..339 CDD:275368 7/21 (33%)
zf-H2C2_2 331..356 CDD:290200 12/134 (9%)
C2H2 Zn finger 347..367 CDD:275368 6/143 (4%)
C2H2 Zn finger 375..395 CDD:275368 7/46 (15%)
C2H2 Zn finger 403..423 CDD:275368 7/57 (12%)
zf-H2C2_2 416..439 CDD:290200 7/29 (24%)
C2H2 Zn finger 431..451 CDD:275368 3/46 (7%)
zf-H2C2_2 443..468 CDD:290200 8/108 (7%)
C2H2 Zn finger 459..479 CDD:275368 7/36 (19%)
zf-H2C2_2 472..496 CDD:290200 9/24 (38%)
C2H2 Zn finger 487..507 CDD:275368 9/19 (47%)
C2H2 Zn finger 515..535 CDD:275368 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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