DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and znf1004

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001107936.1	Gene:	znf1004 / 799653	ZFINID:	ZDB-GENE-080219-20	Length:	934	Species:	Danio rerio

Alignment Length:	911	Identity:	203/911 - (22%)
Similarity:	311/911 - (34%)	Gaps:	280/911 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   297 DDRSDRDNGSLYSGDEFSKDKK--NSS----LIREGD-IDFTDDENGFDIRCEVCDKVYPDLDLL 354
            |:.::::..  :..|:.|:|.|  |:.    |:.||. :....|:|.|  .|..|.|.......|
Zfish    17 DEETEKETD--FIEDDKSEDDKPVNADKMPHLLTEGTFLIKRKDKNCF--TCSQCGKSLGRKSSL 77

  Fly   355 DDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRA 419
            :.|:  ..|..:..:.|.||...|.....|..|..| |...|.|:|..|.|.|.:.|||..| |.
Zfish    78 EIHM--RIHTGERPYTCTQCGKSFRQSSSLTLHMTI-HTGERPYTCTQCGKSFMNSSNLNNH-RL 138

  Fly   420 YHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHA------ 478
            .|.|.:.|.|.:|||:|..::.||.|..:|:.|||::|.||.|:::..|:|..|:::|.
Zfish   139 IHTGKKTHKCDQCGKSFLRAADLKAHFRVHTKVKPYSCSVCGKSFSTESHLRGHQKIHTGVKEYM 203

  Fly   479 ---------------------TCRMQIKCDKCNQSFSTLTSLTKH----------------KKF- 505
                                 |.....||..|::.|:.|.|...|                |:|
Zfish   204 CFECEKTFISAHHLKRHQMIHTGEKPYKCSHCDKRFNRLESQKSHETIHTGEKSYKCSHCDKRFN 268

  Fly   506 ----------------------CDS---------------TGPGPYRNQH----------VNRHH 523
                                  ||.               ||..||:..|          |..|.
Zfish   269 RLESQKSHETIHTGEKSYKCSHCDKRFRQLRHQKIHERIHTGTKPYKCSHCEKTFGNLGSVKTHE 333

  Fly   524 -----QHPHQ----------------HPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAM 567
                 :.|::                |...|....|.|.|. |      .......:|......:
Zfish   334 MIHTGEKPYKCSHCDKRFSQLGTMKLHERIHTGEKAYTCTQ-C------GKSLGCKSALETHMRI 391

  Fly   568 STPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITS------ 626
            .|...|:...:...||...       ..|.::.|..|.     .|......||...:|:
Zfish   392 HTGEKPYTCTQCGKSFTQS-------SNLKKHMLIHTG-----KKTHKCDQCGKTFLTASYLKLH 444

  Fly   627 --------PVSAFDQKLPFGFLKGENSESQAYDKVTEK-----ELVFKAEEKLKKEPLVQAFEGE 678
                    |.|.......|....|.....:.:..|.|.     :..|...::||:...:..  ||
Zfish   445 LRVHTKEKPYSCSVCGKSFSTELGLRGHQKIHTGVKEYMCFECDKTFLGAQQLKRHKRIHT--GE 507

  Fly   679 EDESRSSLDIK-GKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAE-DDRKSIDIMSTPPPADTP 741
            :....|..|.: .:||    ..||.|.....::..:.|..|::.:: .::|..:.:.|
Zfish   508 KPYKCSHCDKRFNRLE----SQKSHEMIHTGEKSYKCSHCDKRFSQLQNQKIHERIHT------- 561

  Fly   742 SGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQP---LKMRKSHSSAES-- 801
              |:.|.....|.||.:       ...|:.||.   |:|..|    :|   .:..||:..:.|
Zfish   562 --GEKPYKCLHCGKRFS-------QLGNMKLHE---RIHTGE----KPYTCTQCGKSYGRSASLN 610

  Fly   802 -----STSQKSHK----GSS---PTPTPT-------ASPGLTPSPSPPTSAGGELS--STSEGGA 845
                 .|.:|:||    |.|   .|...|       ..|.|.|......:....||  ..:..|.
Zfish   611 NHMLIHTGKKTHKCDQCGKSFLAATRLKTHLRFHTNEKPYLCPVCGKRFAQKAYLSEHQKTHTGV 675

  Fly   846 VPTMAAAAFAADHSALASGPTLPQTHPTFH--------------------PLLLEEIYRSGFPFL 890
            ...|   .|..|.:.|.:...  :.|.|.|                    ....|.|:....|:.
Zfish   676 KEYM---CFECDKTFLRAHQL--KWHQTIHTGEKPYKCSHCDKRFNRLERQTTHERIHTGEKPYK 735

  Fly   891 CQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-------YSCKFCGKVFPRSA 948
            |...|:|                       ||  .:..|||.:.       |:|..|||.|.:|:
Zfish   736 CSHCGKR-----------------------FS--MLAHLKTHETIHTGEKPYTCTRCGKSFAQSS 775

  Fly   949 NLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKK 1013
            ||.||:|.|||.:.:.|..|.:.||.:|.|:.|:|: |.||:|:.|.:|.:||..|::|..|.|.
Zfish   776 NLYRHMRIHTGVKTHKCDQCGKTFSTASCLKIHLRS-HTKEKPYSCTVCGKSFSTQSSLRLHQKI 839

  Fly  1014 H 1014
            |
Zfish   840 H 840

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	35/114 (31%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/33 (18%)
		PTZ00121	<641..>728	CDD:173412	17/93 (18%)
		COG5048	935..>1028	CDD:227381	36/80 (45%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
znf1004	NP_001107936.1	C2H2 Zn finger	64..84	CDD:275368	5/21 (24%)
		zf-H2C2_2	76..101	CDD:290200	7/26 (27%)
		COG5048	88..502	CDD:227381	89/434 (21%)
		C2H2 Zn finger	92..112	CDD:275368	7/20 (35%)
		C2H2 Zn finger	120..140	CDD:275368	9/20 (45%)
		C2H2 Zn finger	148..168	CDD:275368	8/19 (42%)
		C2H2 Zn finger	176..196	CDD:275368	7/19 (37%)
		C2H2 Zn finger	204..224	CDD:275368	0/19 (0%)
		zf-H2C2_2	216..241	CDD:290200	5/24 (21%)
		C2H2 Zn finger	232..252	CDD:275368	6/19 (32%)
		C2H2 Zn finger	260..280	CDD:275368	2/19 (11%)
		C2H2 Zn finger	288..308	CDD:275368	2/19 (11%)
		C2H2 Zn finger	316..336	CDD:275368	3/19 (16%)
		C2H2 Zn finger	344..364	CDD:275368	1/19 (5%)
		C2H2 Zn finger	372..392	CDD:275368	3/26 (12%)
		zf-H2C2_2	384..409	CDD:290200	5/24 (21%)
		C2H2 Zn finger	400..420	CDD:275368	4/26 (15%)
		C2H2 Zn finger	428..448	CDD:275368	3/19 (16%)
		C2H2 Zn finger	456..476	CDD:275368	2/19 (11%)
		COG5048	480..864	CDD:227381	100/421 (24%)
		C2H2 Zn finger	484..504	CDD:275368	3/19 (16%)
		zf-H2C2_2	497..521	CDD:290200	6/25 (24%)
		C2H2 Zn finger	512..532	CDD:275368	7/23 (30%)
		C2H2 Zn finger	540..560	CDD:275368	3/19 (16%)
		C2H2 Zn finger	568..588	CDD:275368	7/29 (24%)
		C2H2 Zn finger	596..616	CDD:275368	3/19 (16%)
		C2H2 Zn finger	624..644	CDD:275368	4/19 (21%)
		C2H2 Zn finger	652..672	CDD:275368	3/19 (16%)
		C2H2 Zn finger	680..700	CDD:275368	5/21 (24%)
		C2H2 Zn finger	708..728	CDD:275368	1/19 (5%)
		C2H2 Zn finger	736..756	CDD:275368	8/44 (18%)
		C2H2 Zn finger	764..784	CDD:275368	11/19 (58%)
		zf-H2C2_2	776..801	CDD:290200	11/24 (46%)
		C2H2 Zn finger	792..812	CDD:275368	8/20 (40%)
		C2H2 Zn finger	820..840	CDD:275368	8/19 (42%)
		C2H2 Zn finger	848..868	CDD:275368
		C2H2 Zn finger	876..896	CDD:275368
		zf-H2C2_2	888..913	CDD:290200
		C2H2 Zn finger	904..924	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000