DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF419

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001091961.1	Gene:	ZNF419 / 79744	HGNCID:	20648	Length:	511	Species:	Homo sapiens

Alignment Length:	675	Identity:	115/675 - (17%)
Similarity:	168/675 - (24%)	Gaps:	384/675 - (56%)

- Green bases have known domain annotations that are detailed below.

  Fly   360 GAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGA 424
            |..|:|     |.:|...|..:.||::|:.: |...:.|.|..|.|:|.|.|||..| :..|.|.
Human   200 GKRHYK-----CSECGKAFGQKYLLVQHQRL-HAGKKTYECSECGKLFRDMSNLFIH-QIVHTGE 257

  Fly   425 RCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKC 489
            |.:.|..|||:|..::.|.:||.:|:..|||.|..|.||:...|.|.:|.::|...| ..:|.:|
Human   258 RPYGCSNCGKSFSRNAHLIEHQRVHTGEKPFTCSECGKAFRHNSTLVQHHKIHTGVR-PYECSEC 321

  Fly   490 NQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSE 554
            .:.||..:||.||::.  .||..||:.....:.:.|
Human   322 GKLFSFNSSLMKHQRI--HTGERPYKCSECGKFYSH----------------------------- 355

  Fly   555 SSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGC 619

Human   356 ----------------------------------------------------------------- 355

  Fly   620 GGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRS 684
                                                            |..|::.:
Human   356 ------------------------------------------------KSNLIKHW--------- 363

  Fly   685 SLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLD 749
                                        ||.|                           |:.|..
Human   364 ----------------------------RVHT---------------------------GERPYK 373

  Fly   750 LSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPT 814
            .|.|     |.|||..:  :||.|                               ||.|.|..|
Human   374 CSDC-----GKFFTQCS--SLMQH-------------------------------QKVHTGEKP- 399

  Fly   815 PTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLL 879

Human   400 ----------------------------------------------------------------- 399

  Fly   880 EEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVF 944
                                                                   :.|..||:.|
Human   400 -------------------------------------------------------FKCNECGRFF 409

  Fly   945 PRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDR 1009
            ..::.|.||.|.|||.:||.|:.|.:.||.||.|.:| |.:|..|:||:|..|.|.|.:.::|.:
Human   410 RENSTLVRHQRVHTGAKPYECRECGKFFSQSSTLMQH-RKVHIGEKPFKCNECGRLFRENSSLVK 473

  Fly  1010 HVKKHESE--------GNNFRDSPS 1026
            |.:.|...        |..||.:.|
Human   474 HQRVHTGAKPYECRECGKFFRHNSS 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	1/2 (50%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	37/100 (37%)
		zf-C2H2	935..957	CDD:395048	8/21 (38%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF419	NP_001091961.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		C2H2 Zn finger	151..182	CDD:275368
		C2H2 Zn finger	206..226	CDD:275368	6/20 (30%)
		C2H2 Zn finger	234..254	CDD:275368	9/20 (45%)
		COG5048	<262..418	CDD:227381	60/523 (11%)
		C2H2 Zn finger	262..282	CDD:275368	8/19 (42%)
		zf-H2C2_2	274..299	CDD:290200	11/24 (46%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	8/21 (38%)
		zf-H2C2_2	330..355	CDD:290200	8/26 (31%)
		C2H2 Zn finger	346..366	CDD:275368	4/198 (2%)
		C2H2 Zn finger	374..394	CDD:275368	11/57 (19%)
		zf-H2C2_2	386..409	CDD:290200	11/174 (6%)
		C2H2 Zn finger	402..422	CDD:275368	8/19 (42%)
		zf-H2C2_2	415..439	CDD:290200	12/23 (52%)
		C2H2 Zn finger	430..450	CDD:275368	9/20 (45%)
		zf-H2C2_2	443..465	CDD:290200	10/22 (45%)
		C2H2 Zn finger	458..478	CDD:275368	6/19 (32%)
		zf-H2C2_2	470..495	CDD:290200	5/24 (21%)
		C2H2 Zn finger	486..506	CDD:275368	4/13 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910