DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and prdm16

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_021334166.1	Gene:	prdm16 / 796720	ZFINID:	ZDB-GENE-080613-2	Length:	1336	Species:	Danio rerio

Alignment Length:	1273	Identity:	360/1273 - (28%)
Similarity:	515/1273 - (40%)	Gaps:	373/1273 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREPV-CELDIRDSG------GVYAKTPL 160
            |::|..:|....:.|     |..:..:.:.:..::....|: .:|::|:|.      |::||..:
Zfish    45 PVAVGPASPQPCNED-----FTPKEGSPYEVPVYIPDDIPIPADLELRESSVPGAGLGIWAKVKI 104

  Fly   161 QRGTRYGPFPMKLSHQPNDPQLAWKAHSRHY-----------------------NGWLEPTEDVS 202
            :.|.|:||:....|....:....|:.....:                       :|.||.:.  |
Zfish   105 RMGERFGPYNGLQSATVKETTYGWEQMLNDHETSSQDSCIKKVMDNMGNVKFCLDGALEASG--S 167

  Fly   203 TWLKKIRSVQDDCIGEANL-QSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKV 266
            .|||.:|:.....  |.|| ..:|:...::|:..|.:..|.|::|             :|..|..
Zfish   168 CWLKYVRTAPSHL--EHNLAMCHISEDQIYYKAIRDIEIGEELLV-------------YMKDGVF 217

  Fly   267 LAAAAAAAAAVVAASSSGAKSGGGGSSAPS--DD---RSDRDNGSLYSGDEFSKDKKNS-----S 321
                                  ..||.||:  |:   |.:..:....|..|..:.:|.|     |
Zfish   218 ----------------------PEGSMAPNLEDEQMYRCEHCDELFTSKLELRRHQKYSCSSGNS 260

  Fly   322 LIREGDIDFTDDENGFD---IRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPL 383
            :......||..:....|   ..|:.|:|::|....|..|:|  .|.::.|:.|.||...|..:..
Zfish   261 IFDSLSEDFKQEREDSDEPVHECKDCEKIFPSEYSLGQHMI--VHTEEREYKCDQCPKAFNWKSN 323

  Fly   384 LIKHEAISHNNIRKYSCENCSK----VFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQ 444
            ||:|: :||::.:::.||||.|    ||.||||||||||:.|||||.|.||||||||.|||||||
Zfish   324 LIRHQ-MSHDSGKRFECENCDKVGDSVFTDPSNLQRHIRSQHVGARAHTCPECGKTFATSSGLKQ 387

  Fly   445 HQHIHSSVKPFAC----------------------------------EVCSKAYTQFSNLCRHKR 475
            |:|||||||||:|                                  |||.|:||||||||||||
Zfish   388 HKHIHSSVKPFSCKSEQSCLSLRYNYQCPKTSRLAPPQDCDSCCFIGEVCHKSYTQFSNLCRHKR 452

  Fly   476 MHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTG---------PG-PYRNQHV-NRHHQHPH-Q 528
            |||.||.||||..|.|.|||.:||.||::||:...         || |..:..: .:...||. .
Zfish   453 MHADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHYNPGGIFTPGIPMTSSPILGKSKSHPGLN 517

  Fly   529 HP-------LPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPG 586
            |.       .|.:||.|....|  |.||             |..|:|             ..|||
Zfish   518 HSGLGFGDYFPSRPHHAGLPFS--PGPP-------------AFPAIS-------------HGFPG 554

  Fly   587 -FPP--YGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGG--PEITSPVSAFDQKL---------PF 637
             |||  |..||.||         |....|:|::....|  |.:.:|..:....:         ..
Zfish   555 IFPPSLYPRPPLLP---------PSSLLKSPLNNSQDGKLPHLDAPALSVASSMNNSNGNIGSSL 610

  Fly   638 GFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTR------ 696
            .....||.||:.....||.      :.|:|...:....:.|:..:.|..|:     ||.
Zfish   611 SSQSEENRESKLDLSFTEN------KNKVKMNDMSDGSDLEDVNTSSGTDL-----DTTTGTVSG 664

  Fly   697 NDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMST-----------------PPPAD---TP 741
            :|.:||.:.| :::..|....:.:|.|....|:.:.|:                 |||.:   .|
Zfish   665 SDLESEAESD-REKSRRKPAQESKQDEVSSSSVSVSSSGNLPCERPFLSSQHSFFPPPEEQALPP 728

  Fly   742 SGG--DGPLDLSICRKRSAGSFFTAPAE---DNLMLH-----RFMPR----LHEFEAERGQPLKM 792
            ||.  |....::...::..|..|....|   .:|..|     :|:|.    |:.|......|...
Zfish   729 SGATTDSIKAIASIAEKYFGPGFMGLQEKKMGSLNYHSMFPFQFLPNFPHSLYPFTDRALNPGMF 793

  Fly   793 RKSHSSAESSTSQKSHKGS---SPTPTPTASPGLTPSPSPPT--------------------SAG 834
            .|....:.....||.|..:   ||....|....:.|.|.||:                    |.|
Zfish   794 FKPEPKSPREHIQKLHTATGADSPFDLTTKPKEIKPLPPPPSKPALPSNALLASGEEQPLDLSIG 858

  Fly   835 GELSSTSEGGA-------VPTMAAAAFAADHSALASG---------------PTLPQTHPTFHPL 877
            ....::..||.       |......|...:|.||...               |.:||..|:.|
Zfish   859 SRSRASHNGGTHEQRKNHVYGTNCKAAKDEHPALNQNLHQPQMPQQHTSLPQPPVPQQQPSLH-- 921

  Fly   878 LLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPK--RPLPPV----------------KFSA- 923
                 |....||...|...|..:..|.....|...|  ||.|.:                .|||
Zfish   922 -----YAKPSPFFMDPIYSRVEKRKLLDPVGALKEKYLRPTPLLFHPQVSAMENMTEKLESFSAL 981

  Fly   924 -------------------------GSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPY 963
                                     ...:..|.|:||:|::|||:||||||||||||||||||||
Zfish   982 KLDAPNSLQHSSHHLFNFRSPPPSLSDAILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPY 1046

  Fly   964 PCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE----------- 1017
            .||||||:||||||||||||||||||:||:|.||:|.||||||||||:||||.|
Zfish  1047 RCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENIPVSQQSGIL 1111

  Fly  1018 ---GNNFRDSPSSSG-----IAEREE-YFDDIRKFMNRVYTPNSLAGNEGDT----EEYPNSDDQ 1069
               |.|. .||:|..     :.|:|: ||.:||.|::......:.:.:|..:    ||:|.|...
Zfish  1112 SNLGTNI-SSPNSESDNHALLDEKEDSYFSEIRNFISNSELNQACSSSEKRSELAEEEHPQSHTL 1175

  Fly  1070 SVN-LEKDSGNFNNNSSNISNNNSSSGNNNNSSKAITI 1106
            :.: ||::......:..:...:.:....:..:|.|..:
Zfish  1176 TASKLEEEEEEMEGDDEDEEGSLTEKSQDETASPATMV 1213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	30/152 (20%)
		C2H2 Zn finger	341..363	CDD:275368	7/21 (33%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	69/125 (55%)
		C2H2 Zn finger	400..421	CDD:275368	17/24 (71%)
		SUF4-like	403..>445	CDD:411020	34/45 (76%)
		C2H2 Zn finger	403..421	CDD:411020	14/21 (67%)
		C2H2 Zn finger	429..449	CDD:275368	17/19 (89%)
		C2H2 Zn finger	457..477	CDD:275368	17/53 (32%)
		C2H2 Zn finger	486..504	CDD:275368	10/17 (59%)
		PTZ00121	<641..>728	CDD:173412	20/92 (22%)
		COG5048	935..>1028	CDD:227381	74/106 (70%)
		zf-C2H2	935..957	CDD:395048	17/21 (81%)
		C2H2 Zn finger	937..957	CDD:275368	16/19 (84%)
		zf-H2C2_2	949..973	CDD:404364	21/23 (91%)
		C2H2 Zn finger	965..986	CDD:275368	19/20 (95%)
		C2H2 Zn finger	994..1014	CDD:275368	15/19 (79%)
prdm16	XP_021334166.1	SET	85..210	CDD:214614	27/128 (21%)
		C2H2 Zn finger	234..275	CDD:275368	7/40 (18%)
		C2H2 Zn finger	283..303	CDD:275368	7/21 (33%)
		zf-H2C2_2	298..319	CDD:316026	7/22 (32%)
		C2H2 Zn finger	311..331	CDD:275368	7/20 (35%)
		C2H2 Zn finger	339..361	CDD:275368	15/21 (71%)
		zf-C2H2	370..392	CDD:306579	18/21 (86%)
		C2H2 Zn finger	372..392	CDD:275368	17/19 (89%)
		C2H2 Zn finger	400..454	CDD:275368	17/53 (32%)
		C2H2 Zn finger	463..481	CDD:275368	10/17 (59%)
		COG5048	998..>1174	CDD:227381	90/176 (51%)
		zf-C2H2	1018..1040	CDD:306579	17/21 (81%)
		C2H2 Zn finger	1020..1040	CDD:275368	16/19 (84%)
		zf-H2C2_2	1032..1056	CDD:316026	21/23 (91%)
		zf-H2C2_5	1046..1071	CDD:316431	22/24 (92%)
		C2H2 Zn finger	1048..1069	CDD:275368	19/20 (95%)
		C2H2 Zn finger	1077..1097	CDD:275368	15/19 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	53	1.000	Domainoid score	I11374
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3196
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm26104
orthoMCL	1	0.900	-	-		OOG6_105951
Panther	1	1.100	-	-	LDO	PTHR24393
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4598
SonicParanoid	1	1.000	-	-		X2993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	10.000