DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF426

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_077011.1	Gene:	ZNF426 / 79088	HGNCID:	20725	Length:	554	Species:	Homo sapiens

Alignment Length:	816	Identity:	138/816 - (16%)
Similarity:	212/816 - (25%)	Gaps:	433/816 - (53%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 GGGSSAPS------DDRSDRDNGSLYSGDEFSKDKKNSSLIRE---GD----IDFTDDENGFDI- 339
            ||....||      .:.|....|.:..|.|...:.:.|.|.::   |.    |......||.::
Human    82 GGQIIKPSLISWLEQEESRTVQGGVLQGWEMRLETQWSILQQDFLRGQTSIGIQLEGKHNGRELC 146

  Fly   340 RCEVCDKVYPDLDLLDDHL----IGAHH------------------------FKQDE-------- 368
            .||.|.:|:.:...|..|:    .|..|                        |.|.|
Human   147 DCEQCGEVFSEHSCLKTHVRTQSTGNTHDCNQYGKDFLTLCEKTSTGEKLSEFNQSEKIFSLTPN 211

  Fly   369 ------------FPCKQCALRFCHRPLLIKHEAISHN---------------------------N 394
                        |.|..|...|.:...|..|.. :||                           |
Human   212 IVYQRTSTQEKSFECSHCGKSFINESYLQAHMR-THNGEKLYEWRNYGPGFIDSTSLSVLIETLN 275

  Fly   395 IRK-YSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACE 458
            .:| |.|:.|.|.:..|:.|..|:|. |.|.:.:.|.||||.|..|:..:.|...|:..||:.|:
Human   276 AKKPYKCKECGKGYRYPAYLSIHMRT-HTGEKPYECKECGKAFNYSNSFQIHGRTHTGEKPYVCK 339

  Fly   459 VCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHH 523
            .|.||:||:|.|..|.|.|:..: ..:|.:|.:||.|.:.|.                ||:..|
Human   340 ECGKAFTQYSGLSMHVRSHSGDK-PYECKECGKSFLTSSRLI----------------QHIRTH- 386

  Fly   524 QHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFP 588
                                                         |...||:.
Human   387 ---------------------------------------------TGEKPFVC------------ 394

  Fly   589 PYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKV 653
                                        :.||
Human   395 ----------------------------VECG--------------------------------- 398

  Fly   654 TEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPD 718
                               :||       ..|.::.|.|. |..:.|:
Human   399 -------------------KAF-------AVSSNLSGHLR-THTEEKA----------------- 419

  Fly   719 QQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFE 783
                                              |..:..|..|..|:    .|:..|
Human   420 ----------------------------------CECKICGKVFGYPS----CLNNHM------- 439

  Fly   784 AERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPT 848
                      ::||:.:..|.::..|
Human   440 ----------RTHSAQKPYTCKECGK--------------------------------------- 455

  Fly   849 MAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPK 913
                  |.::|          ||...|
Human   456 ------AFNYS----------THLKIH-------------------------------------- 466

  Fly   914 RPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNL 978
                 ::...|       :..|.||.|||.|..|::...|.||||||:||.||.|.:||:.||:.
Human   467 -----MRIHTG-------EKPYECKQCGKAFSHSSSFQIHERTHTGEKPYECKECGKAFTCSSSF 519

  Fly   979 QRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKH 1014
            :.|.:. |.:|:|::|:.|.:::....:|.||.:.|
Human   520 RIHEKT-HTEEKPYKCQQCGKAYSHPRSLRRHEQIH 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/25 (28%)
		C2H2 Zn finger	371..392	CDD:275368	5/20 (25%)
		SFP1	<391..479	CDD:227516	36/115 (31%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	7/86 (8%)
		COG5048	935..>1028	CDD:227381	34/80 (43%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF426	NP_077011.1	KRAB	42..98	CDD:214630	4/15 (27%)
		C2H2 Zn finger	148..168	CDD:275368	6/19 (32%)
		C2H2 Zn finger	176..214	CDD:275368	3/37 (8%)
		zf-C2H2	224..246	CDD:306579	6/22 (27%)
		C2H2 Zn finger	226..246	CDD:275368	5/20 (25%)
		C2H2 Zn finger	282..302	CDD:275368	7/20 (35%)
		zf-H2C2_2	294..319	CDD:316026	11/25 (44%)
		C2H2 Zn finger	310..330	CDD:275368	8/19 (42%)
		COG5048	<334..486	CDD:227381	56/491 (11%)
		C2H2 Zn finger	338..358	CDD:275368	10/19 (53%)
		C2H2 Zn finger	366..386	CDD:275368	8/35 (23%)
		C2H2 Zn finger	394..414	CDD:275368	7/119 (6%)
		C2H2 Zn finger	422..442	CDD:275368	5/40 (13%)
		C2H2 Zn finger	450..470	CDD:275368	6/117 (5%)
		C2H2 Zn finger	478..498	CDD:275368	9/19 (47%)
		zf-H2C2_2	490..515	CDD:316026	14/24 (58%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910