DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF236

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001293018.1 Gene:ZNF236 / 7776 HGNCID:13028 Length:1847 Species:Homo sapiens


Alignment Length:1172 Identity:271/1172 - (23%)
Similarity:406/1172 - (34%) Gaps:340/1172 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 HLD----LSARSQGFNPL----SEQIEDSFAARHHLPQQEPVEGSPPRRDHLDIQDQELLHH--- 84
            |:|    .|...|.|.|.    ...:.|::   |..||..||:         .:||...|..   
Human   863 HVDQFEEQSPAQQSFEPAGLPQGFTVTDTY---HQQPQFPPVQ---------QLQDSSTLESQAL 915

  Fly    85 PNHFHQQNQRQQPPPPTLPLSVESSSAAAASVDGMDA---FFKDRAQAEHILQ----------EW 136
            ...||||:..|.|                 |.|||:.   ..::.:|.|..||          |.
Human   916 STSFHQQSLLQAP-----------------SSDGMNVTTRLIQESSQEELDLQAQGSQFLEDNED 963

  Fly   137 VRRREPVCELDIRDSG---GVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHY--NGWLE 196
            ..||...|  |..:.|   ..:.|..::..|...|:..||.             .|.:  :|.|:
Human   964 QSRRSYRC--DYCNKGFKKSSHLKQHVRSHTGEKPYKCKLC-------------GRGFVSSGVLK 1013

  Fly   197 PTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDF- 260
            ..|...|.:|..     .|       |..||.   :.||..:.......:..:|.......|.| 
Human  1014 SHEKTHTGVKAF-----SC-------SVCNAS---FTTNGSLTRHMATHMSMKPYKCPFCEEGFR 1063

  Fly   261 --MNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLI 323
              ::..|.:.......:||   |::|...||.......::.||| |.|..|..|.          
Human  1064 TTVHCKKHMKRHQTVPSAV---SATGETEGGDICMEEEEEHSDR-NASRKSRPEV---------- 1114

  Fly   324 REGDIDFTDDENG--FDIR----CEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRP 382
                |.||::|..  ..||    ..|.:||........|.:        .|...||..|:     
Human  1115 ----ITFTEEETAQLAKIRPQESATVSEKVLVQSAAEKDRI--------SELRDKQAELQ----- 1162

  Fly   383 LLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQH 447
                 :...|.|    .|..|.|.|..||:|.||:| .|.|.:.:.|.||||:|...|.|..|..
Human  1163 -----DEPKHAN----CCTYCPKSFKKPSDLVRHVR-IHTGEKPYKCDECGKSFTVKSTLDCHVK 1217

  Fly   448 IHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPG 512
            .|:..|.|:|.|||.|::...:|..|.|:| |.....||..|...|.|......|.:|       
Human  1218 THTGQKLFSCHVCSNAFSTKGSLKVHMRLH-TGAKPFKCPHCELRFRTSGRRKTHMQF------- 1274

  Fly   513 PYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMF 577
                          |..|.|.:.....|.:|:....|.....||           ||.||.|:|.
Human  1275 --------------HYKPDPKKARKPMTRSSSEGLQPVNLLNSS-----------STDPNVFIMN 1314

  Fly   578 RTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLP------ 636
            .   |...|        ...||.|.|..:.....  |..:..|| ::|  ||..|..|.      
Human  1315 N---SVLTG--------QFDQNLLQPGLVGQAIL--PASVSAGG-DLT--VSLTDGSLATLEGIQ 1363

  Fly   637 ---FGFLKGENSESQAYDKVTEKELVFKAEEKLKKEP------LVQAFEGE-----EDESRSSLD 687
               ...|.|.|.:....|..:...:..:.:..:.::.      |.|...||     ::.|..:.|
Human  1364 LQLAANLVGPNVQISGIDAASINNITLQIDPSILQQTLQQGNLLAQQLTGEPGLAPQNSSLQTSD 1428

  Fly   688 -----------IKG-KLEDTRNDSK-----SEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTP 735
                       |.| .|:.|...:.     ..|||.       |.|.:....:|    :..:.|.
Human  1429 STVPASVVIQPISGLSLQPTVTSANLTIGPLSEQDS-------VLTTNSSGTQD----LTQVMTS 1482

  Fly   736 PPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAE 800
            ....:||||...:.|:|               :|..|.:.:       |:...|.....|.|..|
Human  1483 QGLVSPSGGPHEITLTI---------------NNSSLSQVL-------AQAAGPTATSSSGSPQE 1525

  Fly   801 ---SSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGG-AVPTMAAAAFAADHSAL 861
               :.:...:..||.|:.||.       |||..::....:||:..|| |..|:.    .||...:
Human  1526 ITLTISELNTTSGSLPSTTPM-------SPSAISTQNLVMSSSGVGGDASVTLT----LADTQGM 1579

  Fly   862 ASG----PTLPQT-HPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALL------------------ 903
            .||    .||..| .....|.||.:      |.|...||....:.:|                  
Human  1580 LSGGLDTVTLNITSQGQQFPALLTD------PSLSGQGGAGSPQVILVSHTPQSASAACEEIAYQ 1638

  Fly   904 -AGAASAAAPKRPLPPVK-------------FSAGSVVGLKTKD------RYSCKFCGKVFPRSA 948
             ||.:...||..  .|.|             ||:.:|:...:|:      .:.|..|.|.|.|:.
Human  1639 VAGVSGNLAPGN--QPEKEGRAHQCLECDRAFSSAAVLMHHSKEVHGRERIHGCPVCRKAFKRAT 1701

  Fly   949 NLTRHLRTH------TGEQP--YPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQT 1005
            :|..|::||      :.::|  :.|..|::||:..|.|:||.| ||..||||.|.||:::|.|::
Human  1702 HLKEHMQTHQAGPSLSSQKPRVFKCDTCEKAFAKPSQLERHSR-IHTGERPFHCTLCEKAFNQKS 1765

  Fly  1006 NLDRHVKKHESEGNNFRDSPSSSGIAEREEYFDDIRKFMNRVYTPNSLAGNEGDTEEYPNSDDQS 1070
            .|..|:|||..| ..::.:....|..::    .:::..|.|.:   |.||...::..:|..|.:.
Human  1766 ALQVHMKKHTGE-RPYKCAYCVMGFTQK----SNMKLHMKRAH---SYAGALQESAGHPEQDGEE 1822

  Fly  1071 VN 1072
            ::
Human  1823 LS 1824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978 26/136 (19%)
C2H2 Zn finger 341..363 CDD:275368 4/21 (19%)
C2H2 Zn finger 371..392 CDD:275368 3/20 (15%)
SFP1 <391..479 CDD:227516 35/87 (40%)
C2H2 Zn finger 400..421 CDD:275368 10/20 (50%)
SUF4-like 403..>445 CDD:411020 19/41 (46%)
C2H2 Zn finger 403..421 CDD:411020 9/17 (53%)
C2H2 Zn finger 429..449 CDD:275368 9/19 (47%)
C2H2 Zn finger 457..477 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..504 CDD:275368 5/17 (29%)
PTZ00121 <641..>728 CDD:173412 19/114 (17%)
COG5048 935..>1028 CDD:227381 36/100 (36%)
zf-C2H2 935..957 CDD:395048 7/21 (33%)
C2H2 Zn finger 937..957 CDD:275368 7/19 (37%)
zf-H2C2_2 949..973 CDD:404364 8/31 (26%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 8/19 (42%)
ZNF236NP_001293018.1 C2H2 Zn finger 41..61 CDD:275368
COG5048 <52..234 CDD:227381
C2H2 Zn finger 70..90 CDD:275368
C2H2 Zn finger 97..117 CDD:275368
C2H2 Zn finger 125..145 CDD:275370
C2H2 Zn finger 157..177 CDD:275368
COG5048 197..707 CDD:227381
zf-C2H2 199..221 CDD:278523
C2H2 Zn finger 201..221 CDD:275368
zf-H2C2_2 214..238 CDD:290200
C2H2 Zn finger 229..249 CDD:275368
zf-H2C2_2 241..266 CDD:290200
C2H2 Zn finger 257..278 CDD:275368
C2H2 Zn finger 289..310 CDD:275368
C2H2 Zn finger 486..506 CDD:275368
zf-H2C2_2 498..522 CDD:290200
C2H2 Zn finger 514..534 CDD:275368
zf-H2C2_2 527..551 CDD:290200
C2H2 Zn finger 542..562 CDD:275368
zf-H2C2_2 554..579 CDD:290200
C2H2 Zn finger 570..590 CDD:275368
COG5048 653..1057 CDD:227381 53/252 (21%)
C2H2 Zn finger 661..681 CDD:275368
zf-H2C2_2 673..698 CDD:290200
C2H2 Zn finger 689..709 CDD:275368
C2H2 Zn finger 717..737 CDD:275368
zf-H2C2_2 729..754 CDD:290200
C2H2 Zn finger 745..765 CDD:275368
COG5048 953..1315 CDD:227381 111/465 (24%)
zf-C2H2 969..991 CDD:278523 4/23 (17%)
C2H2 Zn finger 971..991 CDD:275368 4/21 (19%)
zf-H2C2_2 983..1008 CDD:290200 6/37 (16%)
C2H2 Zn finger 999..1019 CDD:275368 6/32 (19%)
C2H2 Zn finger 1027..1047 CDD:275368 6/29 (21%)
zf-H2C2_2 1039..1064 CDD:290200 3/24 (13%)
C2H2 Zn finger 1171..1191 CDD:275368 10/20 (50%)
zf-H2C2_2 1183..1207 CDD:290200 11/24 (46%)
C2H2 Zn finger 1199..1219 CDD:275368 9/19 (47%)
C2H2 Zn finger 1227..1247 CDD:275368 8/19 (42%)
zf-H2C2_2 1239..1264 CDD:290200 9/25 (36%)
C2H2 Zn finger 1255..1275 CDD:275370 6/40 (15%)
C2H2 Zn finger 1661..1682 CDD:275368 4/20 (20%)
C2H2 Zn finger 1690..1710 CDD:275368 7/19 (37%)
COG5048 1707..>1775 CDD:227381 27/68 (40%)
C2H2 Zn finger 1726..1746 CDD:275368 9/20 (45%)
zf-H2C2_2 1739..1763 CDD:290200 14/24 (58%)
C2H2 Zn finger 1754..1774 CDD:275368 8/19 (42%)
zf-H2C2_2 1766..1791 CDD:290200 7/25 (28%)
C2H2 Zn finger 1782..1800 CDD:275368 1/21 (5%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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