DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF112

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001335210.1	Gene:	ZNF112 / 7771	HGNCID:	12892	Length:	930	Species:	Homo sapiens

Alignment Length:	825	Identity:	169/825 - (20%)
Similarity:	258/825 - (31%)	Gaps:	357/825 - (43%)

- Green bases have known domain annotations that are detailed below.

  Fly   324 REGDIDFTDDENGFD----------IRCEVCDKVYPDLD-----LLDDHLIGAH--HFKQDEFPC 371
            |:...::.::||.|:          |..|  :|:|.|::     :...:|...|  |.:::.:..
Human   400 RDEPHEYEENENVFNQSSCLQVHQKIHTE--EKLYTDIEYGKSFICSSNLDIQHRVHMEENSYNS 462

  Fly   372 KQCALRFCHRPLLIKH---EAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECG 433
            ::|...|.    |..|   ..|.|...:.|....||..|.....||.|.: .|:|.:  |..|.|
Human   463 EECGNGFS----LASHFQDLQIVHTKEQPYKRYVCSNSFSHNLYLQGHPK-IHIGEK--PRKEHG 520

  Fly   434 KTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTS 498
            ..|..||.||.||.:|:..||:.|.:|.|.:...|.|..|:|:| |.....||::|::.||..:.
Human   521 NGFNWSSKLKDHQRVHTGQKPYKCNICGKGFNHRSVLNVHQRVH-TGEKPYKCEECDKGFSRSSY 584

  Fly   499 LTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAA 563
            |..|::.  .||..||:.:.
Human   585 LQAHQRV--HTGEKPYKCEE--------------------------------------------- 602

  Fly   564 VAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPV 628
                                                                   ||.
Human   603 -------------------------------------------------------CGK------- 605

  Fly   629 SAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLE 693
                     ||  ..||..|.:.:|...|..:|.||..|      .|      |||| .::|.
Human   606 ---------GF--SRNSYLQGHQRVHTGEKPYKCEECGK------GF------SRSS-HLQGH-- 644

  Fly   694 DTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSA 758
                              :||.|                           |:.|.....|.|..:
Human   645 ------------------QRVHT---------------------------GEKPFKCEECGKGFS 664

  Fly   759 GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMR---KSHSSAESSTS-QKSHKGSSPTPTPTA 819
            .||       ||.:|:   |:|..|    :|.|..   |..|.|.:..: |:.|.|..|...
Human   665 WSF-------NLQIHQ---RVHTGE----KPYKCEECGKGFSKASTLLAHQRVHTGEKPYQC--- 712

  Fly   820 SPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYR 884
                       ...|...|..|            :...|.::.||..
Human   713 -----------DECGKSFSQRS------------YLQSHQSVHSGER------------------ 736

  Fly   885 SGFPFLCQPGGRRGI--EALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRS 947
               |::|:..| :|.  .|.|.|........:|                   |.|:.|||.|.:|
Human   737 ---PYICEVCG-KGFSQRAYLQGHQRVHTRVKP-------------------YKCEMCGKGFSQS 778

  Fly   948 ANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVR---------------------------NI 985
            :.|..|.|.|||.:||.|:.|.:.||.||.||.|.|                           .:
Human   779 SRLEAHRRVHTGGKPYKCEVCTKGFSESSRLQAHQRVHVEGRPYKCEQCGKGFSGYSSLQAHHRV 843

  Fly   986 HNKERPFRCELCDRSFGQQTNLDRHVKKHESE--------GNNFRDSPSSSGIAEREEYFDDIRK 1042
            |..|:|::||:|.:.|.|::||..|.:.|..|        |..||   .|||:...:
Human   844 HTGEKPYKCEVCGKGFSQRSNLQAHQRVHTGEKPYKCDACGKGFR---WSSGLLIHQ-------- 897

  Fly  1043 FMNRVYTPNSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNNNSSNI 1087
               ||::.:....:|...::||:|:           |.:.|..::
Human   898 ---RVHSSDKFYKSEDYGKDYPSSE-----------NLHRNEDSV 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/28 (21%)
		C2H2 Zn finger	371..392	CDD:275368	5/23 (22%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	6/20 (30%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	18/86 (21%)
		COG5048	935..>1028	CDD:227381	41/127 (32%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	10/47 (21%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF112	NP_001335210.1	KRAB	25..85	CDD:214630
		C2H2 Zn finger	250..269	CDD:275368
		C2H2 Zn finger	277..297	CDD:275368
		C2H2 Zn finger	305..321	CDD:275368
		C2H2 Zn finger	350..370	CDD:275368
		COG5048	401..773	CDD:227381	119/642 (19%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		C2H2 Zn finger	434..454	CDD:275368	3/19 (16%)
		C2H2 Zn finger	462..482	CDD:275368	5/23 (22%)
		C2H2 Zn finger	520..536	CDD:275368	8/15 (53%)
		C2H2 Zn finger	544..564	CDD:275368	7/19 (37%)
		C2H2 Zn finger	572..592	CDD:275368	6/21 (29%)
		C2H2 Zn finger	600..620	CDD:275368	7/137 (5%)
		C2H2 Zn finger	628..648	CDD:275368	10/52 (19%)
		C2H2 Zn finger	656..676	CDD:275368	8/29 (28%)
		C2H2 Zn finger	684..704	CDD:275368	4/19 (21%)
		C2H2 Zn finger	712..732	CDD:275368	4/45 (9%)
		C2H2 Zn finger	740..760	CDD:275368	6/20 (30%)
		C2H2 Zn finger	768..788	CDD:275368	9/19 (47%)
		SFP1	<780..873	CDD:227516	29/92 (32%)
		C2H2 Zn finger	796..816	CDD:275368	10/19 (53%)
		C2H2 Zn finger	824..844	CDD:275368	0/19 (0%)
		C2H2 Zn finger	852..872	CDD:275368	8/19 (42%)
		zf-H2C2_2	864..888	CDD:316026	6/23 (26%)
		C2H2 Zn finger	880..900	CDD:275368	7/33 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910