DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF227

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001276095.1	Gene:	ZNF227 / 7770	HGNCID:	13020	Length:	799	Species:	Homo sapiens

Alignment Length:	1004	Identity:	196/1004 - (19%)
Similarity:	306/1004 - (30%)	Gaps:	396/1004 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 KTPLQRGTRY-------GPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWL--KKIRSVQ 212
            :|..||.:::       ..|.:|  :..|.....|:.       |.:...:::..|  |..:.:|
Human    85 ETETQRSSKHQNKMETLQKFALK--YLSNQELSCWQI-------WKQVASELTRCLQGKSSQLLQ 140

  Fly   213 DDCI----GEANLQS-------YI-NAGYLWYET-----NRYVNAGSEMVVDGR-----PKSPVQ 255
            .|.|    .|.|:.:       || |..:.::.|     |.|:   ||..:..|     .|:.:|
Human   141 GDSIQVSENENNIMNPKGDSSIYIENQEFPFWRTQHSCGNTYL---SESQIQSRGKQIDVKNNLQ 202

  Fly   256 LNEDFMNG---------------------GKVLAAAAAAAAAVVAASSSGAKSGGGGSSAP---- 295
            ::||||..                     ||:::..:.....:........:.|.|.|.:|
Human   203 IHEDFMKKSPFHEHIKTDTEPKPCKGNEYGKIISDGSNQKLPLGEKPHPCGECGRGFSYSPRLPL 267

  Fly   296 -----------SDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYP 349
                       |.....|.:..::.|::.::..::.....:...
Human   268 HPNVHTGEKCFSQSSHLRTHQRIHPGEKLNRCHESGDCFNKSSF--------------------- 311

  Fly   350 DLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQ 414
                   |...::|..:..:.|..|...|.....||.|.. :|...:.|.||.|.|.|...||.|
Human   312 -------HSYQSNHTGEKSYRCDSCGKGFSSSTGLIIHYR-THTGEKPYKCEECGKCFSQSSNFQ 368

  Fly   415 RHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHAT 479
            .|.|. |...:.:.|.||||.||.|..|:.||.:|...||:.||.|.|.:||.::...|:|:| |
Human   369 CHQRV-HTEEKPYKCEECGKGFGWSVNLRVHQRVHRGEKPYKCEECGKGFTQAAHFHIHQRVH-T 431

  Fly   480 CRMQIKCDKCNQSFSTLTSLTKHKKF--------CDSTGPGPYRNQHVNRHHQHPHQHPLPHQPH 536
            .....|||.|.:.||..:.|..|::.        |::.|.|..||..::.|
Human   432 GEKPYKCDVCGKGFSHNSPLICHRRVHTGEKPYKCEACGKGFTRNTDLHIH-------------- 482

  Fly   537 LAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPL 601
                                                    ||.    ..|..||....
Human   483 ----------------------------------------FRV----HTGEKPYKCKE------- 496

  Fly   602 HPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKL 666
                             ||.                ||.:..|  .|.:..|...|..||.|
Human   497 -----------------CGK----------------GFSQASN--LQVHQNVHTGEKRFKCE--- 523

  Fly   667 KKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDI 731
                                          ...|...|....|..:||.|
Human   524 ------------------------------TCGKGFSQSSKLQTHQRVHT--------------- 543

  Fly   732 MSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFM-------------------- 776
                        |:.|....:|.|..:.|       .||.||:.:
Human   544 ------------GEKPYRCDVCGKDFSYS-------SNLKLHQVIHTGEKPYKCEECGKGFSWRS 589

  Fly   777 -----PRLHEFEAERGQPLKMR---KSHSSA-ESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTS 832
                 .|:|..|    :|.|..   ||.|.| :....|:.|.|..|........|.:.|
Human   590 NLHAHQRVHSGE----KPYKCEQCDKSFSQAIDFRVHQRVHTGEKPYKCGVCGKGFSQS------ 644

  Fly   833 AGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR 897
                                      |.|       |:|        :.::....|:.|...|:
Human   645 --------------------------SGL-------QSH--------QRVHTGEKPYKCDVCGK- 667

  Fly   898 GIEALLAGAASAAAPKRPLPPVKFSAGSVV---GLKTKDRYSCKFCGKVFPRSANLTRHLRTHTG 959
                                ..::|:..:.   |...:..|.|:.|||.|.||.||..|.|.|||
Human   668 --------------------GFRYSSQFIYHQRGHTGEKPYKCEECGKGFGRSLNLRHHQRVHTG 712

  Fly   960 EQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDS 1024
            |:|:.|:.|.:|||:.|||:.|: .:|.:|:.|:||.|.:.|.|...|:.|.:.|..|      .
Human   713 EKPHICEECGKAFSLPSNLRVHL-GVHTREKLFKCEECGKGFSQSARLEAHQRVHTGE------K 770

  Fly  1025 PSSSGIAEREEYFDDIRKFMNRVYTPNSL 1053
            |....|.:::........:..:|:|...|
Human   771 PYKCDICDKDFRHRSRLTYHQKVHTGKKL 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	25/126 (20%)
		C2H2 Zn finger	341..363	CDD:275368	1/21 (5%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	13/86 (15%)
		COG5048	935..>1028	CDD:227381	39/92 (42%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF227	NP_001276095.1	KRAB	23..83	CDD:214630
		C2H2 Zn finger	326..346	CDD:275368	6/20 (30%)
		zf-H2C2_2	342..363	CDD:316026	8/21 (38%)
		C2H2 Zn finger	354..374	CDD:275368	10/20 (50%)
		C2H2 Zn finger	382..402	CDD:275368	11/19 (58%)
		COG5048	406..779	CDD:227381	121/619 (20%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
		C2H2 Zn finger	466..486	CDD:275368	8/77 (10%)
		C2H2 Zn finger	494..514	CDD:275368	6/61 (10%)
		C2H2 Zn finger	522..542	CDD:275368	5/52 (10%)
		C2H2 Zn finger	550..570	CDD:275368	7/26 (27%)
		C2H2 Zn finger	578..598	CDD:275368	1/19 (5%)
		C2H2 Zn finger	606..626	CDD:275368	5/19 (26%)
		C2H2 Zn finger	634..654	CDD:275368	6/66 (9%)
		C2H2 Zn finger	662..682	CDD:275368	3/40 (8%)
		C2H2 Zn finger	690..710	CDD:275368	11/19 (58%)
		C2H2 Zn finger	718..738	CDD:275368	9/20 (45%)
		C2H2 Zn finger	746..766	CDD:275368	7/19 (37%)
		C2H2 Zn finger	774..794	CDD:275368	1/19 (5%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910