DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF224

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001308574.1	Gene:	ZNF224 / 7767	HGNCID:	13017	Length:	707	Species:	Homo sapiens

Alignment Length:	825	Identity:	169/825 - (20%)
Similarity:	254/825 - (30%)	Gaps:	341/825 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 SGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHF-KQDEFPCK 372
            |||:...:.:..|  ..|    |..|..|.   ::.:|:..||....|.:|.:..| |:.:|||:
Human    78 SGDKIQTEMETVS--EAG----THQEWSFQ---QIWEKIASDLTRSQDLMINSSQFSKEGDFPCQ 133

  Fly   373 ----------------------------------------------QCALRFCHRPLLIKHEAIS 391
                                                          :|...||:...|..|:.:
Human   134 TEAGLSVIHTRQKSSQGNGYKPSFSDVSHFDFHQQLHSGEKSHTCDECGKNFCYISALRIHQRV- 197

  Fly   392 HNNIRKYSCENCSKVFCDPSNLQRHIRAY---------------------------HVGARCHPC 429
            |...:.|.|:.|.|.|...|:||.|.|.:                           |.|.:.:.|
Human   198 HMGEKCYKCDVCGKEFSQSSHLQTHQRVHTGEKPFKCVECGKGFSRRSALNVHHKLHTGEKPYNC 262

  Fly   430 PECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFS 494
            .||||.|...|.|::||.||:..|||.|::|.|::...|.|.||..:| |.....:||.|::||.
Human   263 EECGKAFIHDSQLQEHQRIHTGEKPFKCDICGKSFCGRSRLNRHSMVH-TAEKPFRCDTCDKSFR 326

  Fly   495 TLTSLTKHKKFCDSTGPGPYRNQH-----VNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSE 554
            ..::|..|:..  .||..||:.:.     :.|...:.|     |..|     |...|...:|..:
Human   327 QRSALNSHRMI--HTGEKPYKCEECGKGFICRRDLYTH-----HMVH-----TGEKPYNCKECGK 379

  Fly   555 SSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGC 619
            |                     ||.|..            .|....:|....|....:      |
Human   380 S---------------------FRWASC------------LLKHQRVHSGEKPFKCEE------C 405

  Fly   620 GGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRS 684
            |.                ||.  .||:..::.:....|..:|..|.           |:..:.|.
Human   406 GK----------------GFY--TNSQCYSHQRSHSGEKPYKCVEC-----------GKGYKRRL 441

  Fly   685 SLDIK------GKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSG 743
            .||..      .||.:.:...||..:.....:.||:.:
Human   442 DLDFHQRVHTGEKLYNCKECGKSFSRAPCLLKHERLHS--------------------------- 479

  Fly   744 GDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKS----HSSAESSTS 804
            |:.|.....|.||     ||    .|..||... |:|..|    :|.|..|.    :|.......
Human   480 GEKPFQCEECGKR-----FT----QNSHLHSHQ-RVHTGE----KPYKCEKCGKGYNSKFNLDMH 530

  Fly   805 QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQ 869
            ||.|.|..|                        .:..|.|  .:...|:....|..|.||
Human   531 QKVHTGERP------------------------YNCKECG--KSFGWASCLLKHQRLHSG----- 564

  Fly   870 THPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR 934
                                                       ::|
Human   565 -------------------------------------------EKP------------------- 567

  Fly   935 YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISS----NLQRHVR------------ 983
            :.|:.|||.|.:::.|..|.|.||||:||.|..|.:.||.||    :.:||.|
Human   568 FKCEECGKRFTQNSQLHSHQRVHTGEKPYKCDECGKGFSWSSTRLTHQRRHSRETPLKCEQHGKN 632

  Fly   984 -----------NIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
                       .:|:.|:|::||.|.:.:.::.|||.|.:.|..|
Human   633 IVQNSFSKVQEKVHSVEKPYKCEDCGKGYNRRLNLDMHQRVHMGE 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	6/66 (9%)
		SFP1	<391..479	CDD:227516	36/114 (32%)
		C2H2 Zn finger	400..421	CDD:275368	9/47 (19%)
		SUF4-like	403..>445	CDD:411020	18/68 (26%)
		C2H2 Zn finger	403..421	CDD:411020	8/44 (18%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	15/92 (16%)
		COG5048	935..>1028	CDD:227381	35/110 (32%)
		zf-C2H2	935..957	CDD:395048	8/21 (38%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	9/47 (19%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF224	NP_001308574.1	KRAB	8..67	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	178..198	CDD:275368	5/20 (25%)
		COG5048	202..641	CDD:227381	133/653 (20%)
		C2H2 Zn finger	206..226	CDD:275368	9/19 (47%)
		zf-H2C2_2	218..243	CDD:290200	4/24 (17%)
		C2H2 Zn finger	234..254	CDD:275368	0/19 (0%)
		C2H2 Zn finger	262..282	CDD:275368	10/19 (53%)
		zf-H2C2_2	275..297	CDD:290200	11/21 (52%)
		C2H2 Zn finger	290..310	CDD:275368	7/19 (37%)
		C2H2 Zn finger	318..338	CDD:275368	7/21 (33%)
		C2H2 Zn finger	346..366	CDD:275368	3/24 (13%)
		C2H2 Zn finger	374..394	CDD:275368	6/52 (12%)
		C2H2 Zn finger	402..422	CDD:275368	6/43 (14%)
		C2H2 Zn finger	430..450	CDD:275368	5/30 (17%)
		C2H2 Zn finger	458..478	CDD:275368	4/19 (21%)
		zf-H2C2_2	471..495	CDD:290200	9/59 (15%)
		C2H2 Zn finger	486..506	CDD:275368	9/29 (31%)
		C2H2 Zn finger	514..534	CDD:275368	4/19 (21%)
		zf-H2C2_2	526..549	CDD:290200	7/48 (15%)
		C2H2 Zn finger	542..562	CDD:275368	4/21 (19%)
		zf-H2C2_2	555..579	CDD:290200	10/90 (11%)
		C2H2 Zn finger	570..590	CDD:275368	8/19 (42%)
		zf-H2C2_2	585..606	CDD:290200	10/20 (50%)
		C2H2 Zn finger	598..618	CDD:275368	6/19 (32%)
		C2H2 Zn finger	654..674	CDD:275368	7/19 (37%)
		C2H2 Zn finger	682..702	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910