DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF180

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_037388.3	Gene:	ZNF180 / 7733	HGNCID:	12970	Length:	692	Species:	Homo sapiens

Alignment Length:	1086	Identity:	197/1086 - (18%)
Similarity:	302/1086 - (27%)	Gaps:	487/1086 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SGSGGDDFDPSASVARHHHHLHHLDLSARSQGFNPLSEQ---IEDSFAARHHLPQQEPVEGSPPR 70
            :|||..|...          |..|:.|...|...|....   .:|||     |||:..::.....
Human    11 AGSGAQDLST----------LLCLEESMEEQDEKPPEPPKVCAQDSF-----LPQEIIIKVEGED 60

  Fly    71 RDHLDIQDQELLHHP----NHFHQQNQRQQPPPPTLPLSV------ESSSAAAASVDGMDAFFKD 125
            ...|.|..||.::..    :...::.....|...||...|      :..|...|:..|.    ||
Human    61 TGSLTIPSQEGVNFKIVTVDFTREEQGTCNPAQRTLDRDVILENHRDLVSWDLATAVGK----KD 121

  Fly   126 RAQAEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRH 190
            ....:.|..|     ||        :.||    .::|.||            :||
Human   122 STSKQRIFDE-----EP--------ANGV----KIERFTR------------DDP---------- 147

  Fly   191 YNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQ 255
               ||...|:|           |||..:...|                          :.|..:.
Human   148 ---WLSSCEEV-----------DDCKDQLEKQ--------------------------QEKQEIL 172

  Fly   256 LNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGS--------------------------SA 294
            |.|......|     |.....|..:..:|.|||...|                          :|
Human   173 LQEVAFTQRK-----AVIHERVCKSDETGEKSGLNSSLFSSPVIPIRNHFHKHVSHAKKWHLNAA 232

  Fly   295 PSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCE---------VCDKVYPD 350
            .:..:...:|.:||..:|..|..::..||:.......|...||..|.:         :.:|::..
Human   233 VNSHQKINENETLYENNECGKPPQSIHLIQFTRTQTKDKSYGFSDRIQSFCHGTPLHIHEKIHGG 297

  Fly   351 LDLLDDHLIG-------AHH------FKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRK----- 397
            ....|....|       :|:      |::.::.|.:.:           |.:....|:|.
Human   298 GKTFDFKECGQVLNPKISHNEQQRIPFEESQYKCSETS-----------HSSSLTQNMRNNSEEK 351

  Fly   398 -YSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCS 461
             :.|..|.|.|...|:|..|.|. |.|.:.:.|.||||:|..||.|..||..|:..||:.|..|.
Human   352 PFECNQCGKSFSWSSHLVAHQRT-HTGEKPYECSECGKSFSRSSHLVSHQRTHTGEKPYRCNQCG 415

  Fly   462 KAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYR-NQHVNRHHQH 525
            |:::|...|..|:|.| |.....:|::|.:||.....|..|::  ..||..||. ||
Human   416 KSFSQSYVLVVHQRTH-TGEKPYECNQCGKSFRQSYKLIAHQR--THTGEKPYECNQ-------- 469

  Fly   526 PHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPY 590

Human   470 ----------------------------------------------------------------- 469

  Fly   591 GFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTE 655
                                        ||                       .|..|:|..:..
Human   470 ----------------------------CG-----------------------KSFIQSYKLIAH 483

  Fly   656 KELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQ 720
                                                                    :|:.|
Human   484 --------------------------------------------------------QRIHT---- 488

  Fly   721 QAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAE 785
                                   |:.|.:.:.|.|..:.|:       .|:.|:   |.|..|
Human   489 -----------------------GEKPYECNQCGKSFSQSY-------KLVAHQ---RTHTGE-- 518

  Fly   786 RGQPLKMR---KSHS-SAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAV 846
              :|.:..   ||.| |::....|::|.|..|...              :..|...:.:|
Human   519 --KPFECNQCGKSFSWSSQLVAHQRTHTGEKPYEC--------------SECGKSFNRSS----- 562

  Fly   847 PTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAA 911
                                        |.::.:.|:....|:.|...|:
Human   563 ----------------------------HLVMHQRIHTGEKPYECNQCGK--------------- 584

  Fly   912 PKRPLPPVKFSAGSVVGLKTKDR-----YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRA 971
                    .||...|:.:..:..     |.|..|||.|.:|:.||:|.||||||:|:.|..|.:.
Human   585 --------SFSQSYVLVVHQRTHTGEKPYECSQCGKSFRQSSCLTQHQRTHTGEKPFECNQCGKT 641

  Fly   972 FSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ||:|:.|..|.|. |..|:||.|..|.::|.....|.||...|..|
Human   642 FSLSARLIVHQRT-HTGEKPFTCIQCGKAFINSYKLIRHQATHTEE 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	20/121 (17%)
		C2H2 Zn finger	341..363	CDD:275368	3/37 (8%)
		C2H2 Zn finger	371..392	CDD:275368	2/20 (10%)
		SFP1	<391..479	CDD:227516	34/93 (37%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	37/83 (45%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF180	NP_037388.3	KRAB	72..133	CDD:214630	11/69 (16%)
		KRAB	72..111	CDD:279668	4/38 (11%)
		C2H2 Zn finger	249..267	CDD:275368	4/17 (24%)
		C2H2 Zn finger	275..295	CDD:275368	3/19 (16%)
		COG5048	332..692	CDD:227381	121/662 (18%)
		C2H2 Zn finger	355..375	CDD:275368	8/20 (40%)
		zf-H2C2_2	367..392	CDD:290200	11/25 (44%)
		C2H2 Zn finger	383..403	CDD:275368	11/19 (58%)
		zf-H2C2_2	395..420	CDD:290200	9/24 (38%)
		C2H2 Zn finger	411..431	CDD:275368	7/19 (37%)
		zf-H2C2_2	424..448	CDD:290200	9/24 (38%)
		C2H2 Zn finger	439..459	CDD:275368	6/21 (29%)
		zf-H2C2_2	455..476	CDD:290200	10/146 (7%)
		C2H2 Zn finger	467..487	CDD:275368	8/199 (4%)
		zf-H2C2_2	483..504	CDD:290200	6/103 (6%)
		C2H2 Zn finger	495..515	CDD:275368	6/29 (21%)
		zf-H2C2_2	508..531	CDD:290200	8/29 (28%)
		C2H2 Zn finger	523..543	CDD:275368	5/19 (26%)
		zf-H2C2_2	536..560	CDD:290200	5/37 (14%)
		C2H2 Zn finger	551..571	CDD:275368	3/66 (5%)
		zf-H2C2_2	563..588	CDD:290200	6/47 (13%)
		C2H2 Zn finger	579..599	CDD:275368	5/42 (12%)
		zf-H2C2_2	592..616	CDD:290200	6/23 (26%)
		C2H2 Zn finger	607..627	CDD:275368	10/19 (53%)
		zf-H2C2_2	620..643	CDD:290200	12/22 (55%)
		C2H2 Zn finger	635..655	CDD:275368	8/20 (40%)
		zf-H2C2_2	648..670	CDD:290200	9/22 (41%)
		C2H2 Zn finger	663..683	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000