DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and Zfp998

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001277125.1	Gene:	Zfp998 / 76803	MGIID:	1924053	Length:	464	Species:	Mus musculus

Alignment Length:	723	Identity:	144/723 - (19%)
Similarity:	224/723 - (30%)	Gaps:	302/723 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 IDFTDDE------NGFDIRCEVCDKVYPDLDLL-----DDHL-------------IGAHHFKQDE 368
            ::||.:|      :..::..:|..:.|.:|..:     |.|:             :.:|.:|: .
Mouse    11 VNFTKEEWNLLEPSQMNLYKDVMLETYWNLTSIGYKWEDHHIEEPCQSSRRHTRHVRSHSWKK-L 74

  Fly   369 FPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECG 433
            :.|.||...|.....|..|:. :|...:.|.|.:|.|.|..|::||||.|. |.|.:.:.|.:|.
Mouse    75 YECNQCGKAFTSHSSLRYHKR-THTGEKPYECNHCGKAFARPAHLQRHKRT-HTGEKPYECNQCS 137

  Fly   434 KTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTS 498
            |.|...|||:.|:..|:..||:.|..|.||:.:.::|..|||.| |.....:|::|.::|:...:
Mouse   138 KAFSCHSGLRYHKRTHTGEKPYECNQCGKAFARPADLQCHKRTH-TGEKPYECNQCGKAFARPAN 201

  Fly   499 LTKHKKFCDSTGPGPYRNQHVN---------RHHQHPHQHPLPHQPHLAATATSTCPAPPRESSE 554
            |..||:  ..||..||......         |:|:..|....|::       .:.|.
Mouse   202 LQCHKR--THTGEKPYECNQCGKAFSCQGGLRYHKRTHTGEKPYE-------CNQCG-------- 249

  Fly   555 SSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGC 619
                      .|.:.|.:.....||    ..|..||....                        |
Mouse   250 ----------KAFARPSHLQCHKRT----HTGEKPYECNQ------------------------C 276

  Fly   620 GGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRS 684
            |        .||...:           |..|.|.|.     ..|:..:.....:||.|     .|
Mouse   277 G--------KAFSSHI-----------SLRYHKRTH-----TGEKPYECNQCGKAFSG-----HS 312

  Fly   685 SLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLD 749
            .|                      :..:|..|                           |:.|.:
Mouse   313 GL----------------------RYHKRTHT---------------------------GEKPYE 328

  Fly   750 LSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPT 814
            .:.|     |..|..|:  :|..|:                               ::|.|..|.
Mouse   329 CNQC-----GKAFATPS--HLQCHK-------------------------------RTHTGEKPY 355

  Fly   815 PTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLL 879
                                 |.:..|:          |||.        |...|.|...|
Mouse   356 ---------------------ECNQCSK----------AFAR--------PAHLQHHKRTH---- 377

  Fly   880 EEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVF 944
                                           ..::|                   |.|..|||.|
Mouse   378 -------------------------------TGEKP-------------------YECNQCGKAF 392

  Fly   945 PRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDR 1009
            .|.::|..|.||||||:||.|..|.:|||..::|:.| :..|..|:|:.|..|.::....|:|..
Mouse   393 ARLSHLQCHKRTHTGEKPYECNQCGKAFSCHNSLRYH-KGTHTGEKPYECNQCGKALATSTHLQC 456

  Fly  1010 HVKKHESE 1017
            |.:.|..|
Mouse   457 HKRTHTGE 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/39 (13%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	9/17 (53%)
		C2H2 Zn finger	429..449	CDD:275368	8/19 (42%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	12/86 (14%)
		COG5048	935..>1028	CDD:227381	34/83 (41%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
Zfp998	NP_001277125.1	KRAB	4..>46	CDD:214630	6/34 (18%)
		KRAB	4..43	CDD:279668	6/31 (19%)
		COG5048	72..452	CDD:227381	130/648 (20%)
		C2H2 Zn finger	77..97	CDD:275368	6/20 (30%)
		zf-H2C2_2	89..114	CDD:290200	8/25 (32%)
		C2H2 Zn finger	105..125	CDD:275368	10/20 (50%)
		zf-H2C2_2	117..142	CDD:290200	11/25 (44%)
		C2H2 Zn finger	133..153	CDD:275368	8/19 (42%)
		zf-H2C2_2	146..170	CDD:290200	9/23 (39%)
		C2H2 Zn finger	161..181	CDD:275368	8/19 (42%)
		zf-H2C2_2	173..198	CDD:290200	9/25 (36%)
		C2H2 Zn finger	189..209	CDD:275368	6/21 (29%)
		zf-H2C2_2	201..226	CDD:290200	7/26 (27%)
		C2H2 Zn finger	217..237	CDD:275368	2/19 (11%)
		zf-H2C2_2	230..254	CDD:290200	6/48 (13%)
		C2H2 Zn finger	245..265	CDD:275368	5/41 (12%)
		zf-H2C2_2	257..282	CDD:290200	9/60 (15%)
		C2H2 Zn finger	273..293	CDD:275368	7/62 (11%)
		zf-H2C2_2	285..309	CDD:290200	6/28 (21%)
		C2H2 Zn finger	301..321	CDD:275368	6/46 (13%)
		zf-H2C2_2	314..338	CDD:290200	8/77 (10%)
		C2H2 Zn finger	329..349	CDD:275368	6/57 (11%)
		zf-H2C2_2	341..366	CDD:290200	9/86 (10%)
		C2H2 Zn finger	357..377	CDD:275368	7/37 (19%)
		zf-H2C2_2	369..394	CDD:290200	10/78 (13%)
		C2H2 Zn finger	385..405	CDD:275368	9/19 (47%)
		zf-H2C2_2	397..422	CDD:290200	14/24 (58%)
		C2H2 Zn finger	413..433	CDD:275368	7/20 (35%)
		C2H2 Zn finger	441..461	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000