DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF69

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_006722936.1	Gene:	ZNF69 / 7620	HGNCID:	13138	Length:	569	Species:	Homo sapiens

Alignment Length:	765	Identity:	148/765 - (19%)
Similarity:	239/765 - (31%)	Gaps:	316/765 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 RSDRDNGSLYSGDEFSKDKKN-SSLIREGDIDFTDDENGFDIRCEVCD--------KVYPDLDLL 354
            :|.:|....|   |:...::| .|||.:...:..||.:..:...:|.|        |..|::...
Human    68 KSWKDQNIEY---EYQNPRRNFRSLIEKKVNEIKDDSHCGETFTQVPDDRLNFQEKKASPEIKSC 129

  Fly   355 DDHL------------------IGAHHFKQDEF---PCKQCALRFCHRP--LLIKHEAI-----S 391
            |..:                  ||...::..|:   |||      |.:|  ....|.:.     .
Human   130 DSFVCGEVGLGNSSFNMNIRGDIGHKAYEYQEYGPKPCK------CQQPKKAFRYHPSFRTPQRD 188

  Fly   392 HNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFA 456
            |...:.|:|:.|.|.|...|::|||: ..|.|...:.|..|||.|...|....|:.||:..||:.
Human   189 HTGEKPYACKECGKTFISHSSIQRHV-VMHSGDGPYKCKFCGKAFHCLSLYLIHERIHTGEKPYE 252

  Fly   457 CEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF--------CDSTGPGP 513
            |:.|.|:::..:.|..|:|.| |.....:|.:|.::|.:.....:|::.        |...|...
Human   253 CKQCGKSFSYSATLRIHERTH-TGEKPYECQQCGKAFHSPRCYRRHERIHTGEKAYQCKECGKAF 316

  Fly   514 YRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFR 578
            ...|:| |.|:..|....|::          |            :....|:::::
Human   317 TCPQYV-RIHERTHSRKKPYE----------C------------TQCGKALSSLT---------- 348

  Fly   579 TAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLG-CGGPEITSPVSAFDQKLPFGFLKG 642
               ||                   .|:|.|...:.|.:.. ||.                ||...
Human   349 ---SF-------------------QTHIRMHSGERPYECKICGK----------------GFCSA 375

  Fly   643 ENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDM 707
              :..|.::|....|..:|.::.           |:.....|||
Human   376 --NSFQRHEKTHSGEKPYKCKQC-----------GKAFIHSSSL--------------------- 406

  Fly   708 KQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLML 772
             :..||:.|                           |:.|.:...|.|....|       .:|.|
Human   407 -RYHERIHT---------------------------GEKPYECKQCGKAFRSS-------SHLQL 436

  Fly   773 HRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGEL 837
            |   .|.|..|    :|.:.::...:..|..:.:||:.:
Human   437 H---GRTHTGE----KPYECQECGKAFRSMKNLQSHERT-------------------------- 468

  Fly   838 SSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEAL 902
                                           |||...|         ||
Human   469 -------------------------------QTHVRIH---------SG---------------- 477

  Fly   903 LAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKY 967
                      :||                   |.||.|||.|....:|.||.:|||||:.|.||.
Human   478 ----------ERP-------------------YKCKLCGKGFYCPKSLQRHEKTHTGEKLYECKQ 513

  Fly   968 CDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |..|||.||:.:.|.|. |..|:|::|:.|.::|...:.|..|.:.|..:
Human   514 CGEAFSSSSSFRYHERT-HTGEKPYKCKQCGKAFRAASVLRMHGRTHPED 562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/47 (15%)
		C2H2 Zn finger	371..392	CDD:275368	5/27 (19%)
		SFP1	<391..479	CDD:227516	30/87 (34%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..504	CDD:275368	4/17 (24%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	35/83 (42%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZNF69	XP_006722936.1	KRAB	27..>67	CDD:214630
		KRAB	27..66	CDD:279668
		C2H2 Zn finger	169..189	CDD:275368	3/19 (16%)
		C2H2 Zn finger	197..217	CDD:275368	8/20 (40%)
		COG5048	222..>540	CDD:227381	106/577 (18%)
		C2H2 Zn finger	225..245	CDD:275368	7/19 (37%)
		zf-H2C2_2	241..262	CDD:290200	8/20 (40%)
		C2H2 Zn finger	253..273	CDD:275368	6/19 (32%)
		zf-H2C2_2	266..290	CDD:290200	8/24 (33%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		zf-H2C2_2	295..318	CDD:290200	3/22 (14%)
		C2H2 Zn finger	309..329	CDD:275368	6/20 (30%)
		C2H2 Zn finger	337..357	CDD:275368	6/63 (10%)
		zf-H2C2_2	349..372	CDD:290200	8/57 (14%)
		C2H2 Zn finger	365..385	CDD:275368	6/37 (16%)
		zf-H2C2_2	377..400	CDD:290200	5/33 (15%)
		C2H2 Zn finger	393..413	CDD:275368	6/52 (12%)
		zf-H2C2_2	405..430	CDD:290200	9/73 (12%)
		C2H2 Zn finger	421..441	CDD:275368	7/29 (24%)
		C2H2 Zn finger	449..468	CDD:275368	3/18 (17%)
		C2H2 Zn finger	483..503	CDD:275368	9/19 (47%)
		zf-H2C2_2	495..520	CDD:290200	14/24 (58%)
		C2H2 Zn finger	511..531	CDD:275368	10/20 (50%)
		zf-H2C2_2	523..546	CDD:290200	7/23 (30%)
		C2H2 Zn finger	539..559	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910