DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF43

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens

Alignment Length:	939	Identity:	224/939 - (23%)
Similarity:	334/939 - (35%)	Gaps:	267/939 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 QEW--VRRREPVCELDIRDSGGV-------YAKTPLQRGT--RYGPFPMKLSHQPNDPQLA--WK 185
            :.|  :||.|.|.:..:..|...       :.|.|.|:.|  ||.....|..|...|.:..  .|
Human    70 EPWEPMRRHEMVAKPPVMCSHFTQDFWPEQHIKDPFQKATLRRYKNCEHKNVHLKKDHKSVDECK 134

  Fly   186 AHSRHYNGWLE--PTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDG 248
            .|...|||:.:  |......:|      .|.|         :.|.:.:..:||:..:.:|
Human   135 VHRGGYNGFNQCLPATQSKIFL------FDKC---------VKAFHKFSNSNRHKISHTE----- 179

  Fly   249 RPKSPVQLNEDFMNGGK---VLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSG 310
              |...:..|    .||   :|...|.........:....:..|...:.||
Human   180 --KKLFKCKE----CGKSFCMLPHLAQHKIIHTRVNFCKCEKCGKAFNCPS-------------- 224

  Fly   311 DEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCA 375
             ..:|.|:    |..|:..:|         ||.|.||:.....|..|......:|.  :.|::|.
Human   225 -IITKHKR----INTGEKPYT---------CEECGKVFNWSSRLTTHKKNYTRYKL--YKCEECG 273

  Fly   376 LRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSS 440
            ..|....:|..|:.| ....:.|.|:.|:|.|...|||..| :..|.|.:.:.|.||||.|...|
Human   274 KAFNKSSILTTHKII-RTGEKFYKCKECAKAFNQSSNLTEH-KKIHPGEKPYKCEECGKAFNWPS 336

  Fly   441 GLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF 505
            .|.:|:.||:..||:.||.|.||:.|||||..|||:| |.....||.:|.::||..::||||||.
Human   337 TLTKHKRIHTGEKPYTCEECGKAFNQFSNLTTHKRIH-TAEKFYKCTECGEAFSRSSNLTKHKKI 400

  Fly   506 CDSTGPGPYRNQHVNRHHQHPH---QHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAM 567
              .|...||:.:...:..:...   :|.|.|        |...|....|..::
Human   401 --HTEKKPYKCEECGKAFKWSSKLTEHKLTH--------TGEKPYKCEECGKA------------ 443

  Fly   568 STPPNPFLMFRTAPSFFPGFPPYGFPPFLPQ-NPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAF 631
                                  :.:|..|.: |.:|....|.....      ||        .||
Human   444 ----------------------FNWPSTLTKHNRIHTGEKPYKCEV------CG--------KAF 472

  Fly   632 DQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSS-LDIKGKLEDT 695
            :|                :..:|..:.:..||:..|.|...:||      |||| |....|:...
Human   473 NQ----------------FSNLTTHKRIHTAEKPYKCEECGKAF------SRSSNLTKHKKIHIE 515

  Fly   696 RNDSKSEE-----QDDMKQEPERVSTPDQQ--QAEDDRKSIDIMSTPPPADTPSGGDGPLDLSIC 753
            :...|.||     :...|....:::...::  :.|:..|:.:..|..........|:.|.....|
Human   516 KKPYKCEECGKAFKWSSKLTEHKITHTGEKPYKCEECGKAFNHFSILTKHKRIHTGEKPYKCEEC 580

  Fly   754 RKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPT 818
                 |..||  ...||..|:   ::|                      |.:|.:|........|
Human   581 -----GKAFT--QSSNLTTHK---KIH----------------------TGEKFYKCEECGKAFT 613

  Fly   819 ASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFH----PLLL 879
            .|..||......|  ||:.....|.|              .|.....||.: |...|    |...
Human   614 QSSNLTTHKKIHT--GGKPYKCEECG--------------KAFNQFSTLTK-HKIIHTEEKPYKC 661

  Fly   880 EE----------------IYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVG 928
            ||                |:....|:.|:..|:                       .|...|.:.
Human   662 EECGKAFKWSSTLTKHKIIHTGEKPYKCEECGK-----------------------AFKLSSTLS 703

  Fly   929 ----LKTKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNK 988
                :.|.:: |.|:.|||.|.||:||..|.:.|||||||.|:.|.:||:.||:|..|.| ||.|
Human   704 THKIIHTGEKPYKCEKCGKAFNRSSNLIEHKKIHTGEQPYKCEECGKAFNYSSHLNTHKR-IHTK 767

  Fly   989 ERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |:|::|:.|.::|.|.:||..|.|.|..|
Human   768 EQPYKCKECGKAFNQYSNLTTHNKIHTGE 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	29/133 (22%)
		C2H2 Zn finger	341..363	CDD:275368	7/21 (33%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	38/87 (44%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	13/19 (68%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	18/94 (19%)
		COG5048	935..>1028	CDD:227381	42/83 (51%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630	0/1 (0%)
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370	5/27 (19%)
		C2H2 Zn finger	185..205	CDD:275368	5/23 (22%)
		C2H2 Zn finger	213..233	CDD:275368	5/38 (13%)
		C2H2 Zn finger	241..261	CDD:275368	7/19 (37%)
		C2H2 Zn finger	269..289	CDD:275368	6/20 (30%)
		COG5048	295..763	CDD:227381	152/621 (24%)
		C2H2 Zn finger	297..317	CDD:275368	8/20 (40%)
		zf-H2C2_2	309..333	CDD:290200	10/24 (42%)
		C2H2 Zn finger	325..345	CDD:275368	9/19 (47%)
		zf-H2C2_2	338..362	CDD:290200	11/23 (48%)
		C2H2 Zn finger	353..373	CDD:275368	13/19 (68%)
		C2H2 Zn finger	381..401	CDD:275368	10/21 (48%)
		zf-H2C2_2	393..417	CDD:290200	9/25 (36%)
		C2H2 Zn finger	409..429	CDD:275368	2/19 (11%)
		zf-H2C2_2	422..445	CDD:290200	6/64 (9%)
		C2H2 Zn finger	437..457	CDD:275368	4/53 (8%)
		zf-H2C2_2	450..474	CDD:290200	8/37 (22%)
		C2H2 Zn finger	465..485	CDD:275368	6/49 (12%)
		zf-H2C2_2	477..502	CDD:290200	7/30 (23%)
		C2H2 Zn finger	521..541	CDD:275368	3/19 (16%)
		zf-H2C2_2	534..558	CDD:290200	2/23 (9%)
		C2H2 Zn finger	549..569	CDD:275368	3/19 (16%)
		zf-H2C2_2	562..586	CDD:290200	6/30 (20%)
		C2H2 Zn finger	577..597	CDD:275368	7/29 (24%)
		zf-H2C2_2	589..614	CDD:290200	7/49 (14%)
		C2H2 Zn finger	605..625	CDD:275368	4/19 (21%)
		zf-H2C2_2	617..642	CDD:290200	8/40 (20%)
		C2H2 Zn finger	633..653	CDD:275368	6/34 (18%)
		C2H2 Zn finger	661..681	CDD:275368	2/19 (11%)
		zf-H2C2_2	674..697	CDD:290200	4/45 (9%)
		C2H2 Zn finger	689..709	CDD:275368	4/42 (10%)
		zf-H2C2_2	702..726	CDD:290200	7/23 (30%)
		C2H2 Zn finger	717..737	CDD:275368	10/19 (53%)
		zf-H2C2_2	729..754	CDD:290200	14/24 (58%)
		COG5048	742..>803	CDD:227381	26/56 (46%)
		C2H2 Zn finger	745..765	CDD:275368	9/20 (45%)
		zf-H2C2_2	757..782	CDD:290200	11/25 (44%)
		C2H2 Zn finger	773..793	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000