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Protein Alignment ham and ZNF41

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001311084.1	Gene:	ZNF41 / 7592	HGNCID:	13107	Length:	821	Species:	Homo sapiens

Alignment Length:	742	Identity:	146/742 - (19%)
Similarity:	228/742 - (30%)	Gaps:	292/742 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LYSGDEFSK-DKKNSSLIREGDID-----FTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAH--- 362
            :::|::..: ||.|....::..:|     :|.::   ...|..|.||:    .|..:|| .|
Human   334 IHAGEKSRECDKSNKVFPQKPQVDVHPSVYTGEK---PYLCTQCGKVF----TLKSNLI-THQKI 390

  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |..|..:.|.:|...|..|..|.:|..| |...:.|.|..|.|.|...|:|..|.:. |.|.:.:
Human   391 HTGQKPYKCSECGKAFFQRSDLFRHLRI-HTGEKPYECSECGKGFSQNSDLSIHQKT-HTGEKHY 453

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.||||.|...|.|:.||.||:..||:.|..|.||:.|.|:...|:|:| |.....:|..|.:|
Human   454 ECNECGKAFTRKSALRMHQRIHTGEKPYVCADCGKAFIQKSHFNTHQRIH-TGEKPYECSDCGKS 517

  Fly   493 FSTLTSLTKHKKFCDSTGPGPY---RNQHVNRH------HQHPHQHPLPHQPHLAATATSTCPAP 548
            |:..:.|..|::.  .||..||   ....|..|      ||..|....|:.          |...
Human   518 FTKKSQLHVHQRI--HTGEKPYICTECGKVFTHRTNLTTHQKTHTGEKPYM----------CAEC 570

  Fly   549 PRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKN 613
            .:..::.|:                                     .:.....|....|  :..|
Human   571 GKAFTDQSN-------------------------------------LIKHQKTHTGEKP--YKCN 596

  Fly   614 PMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLV--QAFE 676
                |||                                   |..::|:..|:.::..:  :.:|
Human   597 ----GCG-----------------------------------KAFIWKSRLKIHQKSHIGERHYE 622

  Fly   677 ----GEEDESRSSLDIKGKLEDTRND------SKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDI 731
                |:....:|:|.:..::......      .|:..|........|:.|
Human   623 CKDCGKAFIQKSTLSVHQRIHTGEKPYVCPECGKAFIQKSHFIAHHRIHT--------------- 672

  Fly   732 MSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSH 796
                        |:.|.:.|.|     |..||..::  |.:|
Human   673 ------------GEKPYECSDC-----GKCFTKKSQ--LRVH----------------------- 695

  Fly   797 SSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSAL 861
                    ||.|.|..|..........|                                |.|.|
Human   696 --------QKIHTGEKPNICAECGKAFT--------------------------------DRSNL 720

  Fly   862 ASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSV 926
            .       ||...|
Human   721 I-------THQKIH--------------------------------------------------- 727

  Fly   927 VGLKTKDR-YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKER 990
                |::: |.|..|||.|...:.|..|.::||||:.|.|..|.:||...:.|..| :.||..::
Human   728 ----TREKPYECGDCGKTFTWKSRLNIHQKSHTGERHYECSKCGKAFIQKATLSMH-QIIHTGKK 787

  Fly   991 PFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |:.|..|.::|..::||.:|.|.|..|
Human   788 PYACTECQKAFTDRSNLIKHQKMHSGE 814

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.