DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF33A

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001265106.1 Gene:ZNF33A / 7581 HGNCID:13096 Length:832 Species:Homo sapiens


Alignment Length:765 Identity:148/765 - (19%)
Similarity:226/765 - (29%) Gaps:341/765 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|..|:|.:.|...|..|  ...|..:..|.|.:|...|.|:..|..|:. :|...:.|.|..|.
Human   379 QCNECEKAFWDKSNLTKH--QRSHTGEKPFECNECGKAFSHKSALTLHQR-THTGEKPYQCNACG 440

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.||..|:|.:|.|. |.|.:.:.|.||||:|..:|.||.||..|:..|||.|..|.|::::.||
Human   441 KTFCQKSDLTKHQRT-HTGLKPYECYECGKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEKSN 504

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRH---------HQH 525
            |.:|:|:|...: ..:|:.|.::|...:.||:|:..  .||..||......:.         ||.
Human   505 LTQHQRIHIGDK-SYECNACGKTFYHKSLLTRHQII--HTGWKPYECYECGKTFCLKSDLTVHQR 566

  Fly   526 PHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPY 590
            .|....|.          .||...:..|..|:.:.               .:||    ..|..||
Human   567 THTGQKPF----------ACPECGKFFSHKSTLSQ---------------HYRT----HTGEKPY 602

  Fly   591 GFPPFLPQNPLHPTNIPMFFSKN-------------PMDLG-CGGPEITSPVSAFDQKLPFGFLK 641
                     ..|... .:|::|:             |.:.. ||        .||.||       
Human   603 ---------ECHECG-KIFYNKSYLTKHNRTHTGEKPYECNECG--------KAFYQK------- 642

  Fly   642 GENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDD 706
                     .::|:.:.:...|:..|.....:||                               
Human   643 ---------SQLTQHQRIHIGEKPYKCNECGKAF------------------------------- 667

  Fly   707 MKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLM 771
                                                          |.|.:            |:
Human   668 ----------------------------------------------CHKSA------------LI 674

  Fly   772 LHRFMPRLHEFEAERGQPLKMRKSHSS--AESST--SQKSHKGSSPTPTPTASPGLTPSPSPPTS 832
            :|:   |.|..|    :|.|..:...|  .:|..  .::.|.|..|                   
Human   675 VHQ---RTHTQE----KPYKCNECGKSFCVKSGLIFHERKHTGEKP------------------- 713

  Fly   833 AGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR 897
                                                                             
Human   714 ----------------------------------------------------------------- 713

  Fly   898 GIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQP 962
                                                 |.|..|||.|...::||.|.|.||||:.
Human   714 -------------------------------------YECNECGKFFRHKSSLTVHHRAHTGEKS 741

  Fly   963 YPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSS 1027
            ..|..|.:.|...|.|.:|.|: |..|:|:.|..|.::|.|::||..|.::|  .|.|..:..  
Human   742 CQCNECGKIFYRKSELAQHQRS-HTGEKPYECNTCRKTFSQKSNLIVHQRRH--IGENLMNEM-- 801

  Fly  1028 SGIAEREEYFDDIRKFMNRVYTPNSLAGNEGDTEEYPN---SDDQSVNLE 1074
                       |||.|..:|...|:        .||.:   |.|..:|::
Human   802 -----------DIRNFQPQVSLHNA--------SEYSHCGESPDDILNVQ 832

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 6/21 (29%)
C2H2 Zn finger 371..392 CDD:275368 6/20 (30%)
SFP1 <391..479 CDD:227516 37/87 (43%)
C2H2 Zn finger 400..421 CDD:275368 9/20 (45%)
SUF4-like 403..>445 CDD:411020 19/41 (46%)
C2H2 Zn finger 403..421 CDD:411020 8/17 (47%)
C2H2 Zn finger 429..449 CDD:275368 11/19 (58%)
C2H2 Zn finger 457..477 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 5/86 (6%)
COG5048 935..>1028 CDD:227381 34/92 (37%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 10/23 (43%)
C2H2 Zn finger 965..986 CDD:275368 7/20 (35%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
ZNF33ANP_001265106.1 KRAB 33..92 CDD:214630
KRAB 33..72 CDD:279668
COG5048 163..537 CDD:227381 56/162 (35%)
C2H2 Zn finger 324..344 CDD:275368
C2H2 Zn finger 352..372 CDD:275368
zf-H2C2_2 364..388 CDD:290200 3/8 (38%)
C2H2 Zn finger 380..400 CDD:275368 6/21 (29%)
zf-H2C2_2 392..417 CDD:290200 7/26 (27%)
C2H2 Zn finger 408..428 CDD:275368 6/20 (30%)
zf-H2C2_2 420..443 CDD:290200 7/23 (30%)
C2H2 Zn finger 436..456 CDD:275368 9/20 (45%)
COG5048 444..820 CDD:227381 125/683 (18%)
zf-H2C2_2 448..471 CDD:290200 10/23 (43%)
C2H2 Zn finger 464..484 CDD:275368 11/19 (58%)
zf-H2C2_2 476..500 CDD:290200 11/23 (48%)
C2H2 Zn finger 492..512 CDD:275368 8/19 (42%)
C2H2 Zn finger 520..540 CDD:275368 6/21 (29%)
C2H2 Zn finger 548..568 CDD:275368 2/19 (11%)
zf-H2C2_2 560..585 CDD:290200 6/34 (18%)
C2H2 Zn finger 576..596 CDD:275368 6/38 (16%)
zf-H2C2_2 589..611 CDD:290200 6/50 (12%)
C2H2 Zn finger 604..624 CDD:275368 3/20 (15%)
zf-H2C2_2 616..639 CDD:290200 3/30 (10%)
C2H2 Zn finger 632..652 CDD:275368 7/43 (16%)
zf-H2C2_2 645..667 CDD:290200 3/21 (14%)
C2H2 Zn finger 660..680 CDD:275368 7/111 (6%)
zf-H2C2_2 672..695 CDD:290200 7/41 (17%)
C2H2 Zn finger 688..708 CDD:275368 2/19 (11%)
C2H2 Zn finger 716..736 CDD:275368 9/19 (47%)
C2H2 Zn finger 744..764 CDD:275368 7/20 (35%)
zf-H2C2_2 756..781 CDD:290200 9/25 (36%)
C2H2 Zn finger 772..792 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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