DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ham and ZNF14

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_066358.2 Gene:ZNF14 / 7561 HGNCID:12924 Length:642 Species:Homo sapiens


Alignment Length:793 Identity:170/793 - (21%)
Similarity:270/793 - (34%) Gaps:250/793 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   301 DRDNGSLYSGDEFSKDKKNSSLIREG----DIDFTDD--ENGFDIRCEVCDKV------------ 347
            |.....||. |...:..||  |:..|    |.|..||  ..|.:.||.:.:::            
Human    22 DSSQKKLYE-DVMQETFKN--LVCLGKKWEDQDIEDDHRNQGKNRRCHMVERLCESRRGSKCGET 83

  Fly   348 ---YPDLDLLDDHLIGA-------------HHF------------KQDEF------PCKQCAL-- 376
               .|::::..:...||             ||.            |.:|:      |||..|:  
Human    84 TSQMPNVNINKETFTGAKPHECSFCGRDFIHHSSLNRHMRSHTGQKPNEYQEYEKQPCKCKAVGK 148

  Fly   377 RFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSG 441
            .|.:.....|||. :|..::.|.|:.|.|.|......|||.|. |.|.:.:.|.:|||||.....
Human   149 TFSYHHCFRKHER-THTGVKPYECKQCGKAFIYYQPFQRHERT-HAGQKPYECKQCGKTFIYYQS 211

  Fly   442 LKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFC 506
            .:  :|.|:..||:.|:.|.||:..:.:..||||.| |.....:|.:|.::||..|....|::  
Human   212 FQ--KHAHTGKKPYECKQCGKAFICYQSFQRHKRTH-TGEKPYECKQCGKAFSCPTYFRTHER-- 271

  Fly   507 DSTGPGPYRNQHVN---------RHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAA 562
            ..||..||:.:...         |.|:..|....|::          |    :|..::...:|: 
Human   272 THTGEKPYKCKECGKAFSFLSSFRRHKRTHSGEKPYE----------C----KECGKAFFYSAS- 321

  Fly   563 AVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSP 627
                          ||.......|..||....                        ||       
Human   322 --------------FRAHVIIHTGARPYKCKE------------------------CG------- 341

  Fly   628 VSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKL 692
                         |..||.:..  :|.|:..:                 ||            |.
Human   342 -------------KAFNSSNSC--RVHERTHI-----------------GE------------KP 362

  Fly   693 EDTRNDSKSEEQDDMKQEPERVSTPDQ-QQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKR 756
            .:.:...||.......:..||..|.:: .:.:...|:....|:....:|...|:.|.:...|.| 
Human   363 YECKRCGKSFSWSISLRLHERTHTGEKPYECKQCHKTFSFSSSLREHETTHTGEKPYECKQCGK- 426

  Fly   757 SAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESST----SQKSHKGSSPTPTP 817
                  |.....:|..|.   |.|..|    :|.:.::...:...|:    .::||.|..|....
Human   427 ------TFSFSSSLQRHE---RTHNAE----KPYECKQCGKAFRCSSYFRIHERSHTGEKPYECK 478

  Fly   818 TASPGLTPSPSPPTSAGGELSSTSEGGAVP--------TMAAAAFAADHSALASGPTLPQTHPTF 874
            ........|.|      ..|...:..|..|        |.:.::...:|                
Human   479 QCGKVFIRSSS------FRLHERTHTGEKPYECKLCGKTFSFSSSLREH---------------- 521

  Fly   875 HPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKF 939
                 |:|:....||.|:..|:    |.|..:           .::....:..|.|.   |.||.
Human   522 -----EKIHTGNKPFECKQCGK----AFLRSS-----------QIRLHERTHTGEKP---YQCKQ 563

  Fly   940 CGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQ 1004
            |||.|..|:....|.||||||:||.||.|.:||..||:::.|.|: |..|:|:.|:.|.::|...
Human   564 CGKAFISSSKFRMHERTHTGEKPYRCKQCGKAFRFSSSVRIHERS-HTGEKPYECKQCGKAFISS 627

  Fly  1005 TNLDRHVKKHESE 1017
            ::...|.:.|..|
Human   628 SHFRLHERTHMGE 640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 4/49 (8%)
C2H2 Zn finger 371..392 CDD:275368 7/22 (32%)
SFP1 <391..479 CDD:227516 31/87 (36%)
C2H2 Zn finger 400..421 CDD:275368 8/20 (40%)
SUF4-like 403..>445 CDD:411020 15/41 (37%)
C2H2 Zn finger 403..421 CDD:411020 7/17 (41%)
C2H2 Zn finger 429..449 CDD:275368 7/19 (37%)
C2H2 Zn finger 457..477 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 13/87 (15%)
COG5048 935..>1028 CDD:227381 35/83 (42%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 13/23 (57%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 4/19 (21%)
ZNF14NP_066358.2 KRAB 4..>46 CDD:214630 8/26 (31%)
KRAB 4..43 CDD:279668 7/23 (30%)
C2H2 Zn finger 80..97 CDD:275368 1/16 (6%)
C2H2 Zn finger 105..125 CDD:275368 2/19 (11%)
C2H2 Zn finger 143..163 CDD:275368 5/20 (25%)
C2H2 Zn finger 171..191 CDD:275368 8/20 (40%)
C2H2 Zn finger 199..217 CDD:275368 7/19 (37%)
C2H2 Zn finger 225..245 CDD:275368 8/19 (42%)
zf-H2C2_2 237..262 CDD:290200 9/25 (36%)
COG5048 249..633 CDD:227381 105/549 (19%)
C2H2 Zn finger 253..273 CDD:275368 6/21 (29%)
zf-H2C2_2 265..289 CDD:290200 5/25 (20%)
C2H2 Zn finger 281..301 CDD:275368 2/19 (11%)
zf-H2C2_2 293..316 CDD:290200 6/36 (17%)
C2H2 Zn finger 309..329 CDD:275368 5/38 (13%)
C2H2 Zn finger 337..357 CDD:275368 7/65 (11%)
C2H2 Zn finger 365..385 CDD:275368 4/19 (21%)
zf-H2C2_2 377..401 CDD:290200 4/23 (17%)
C2H2 Zn finger 393..413 CDD:275368 3/19 (16%)
zf-H2C2_2 405..429 CDD:290200 6/30 (20%)
C2H2 Zn finger 421..441 CDD:275368 6/29 (21%)
C2H2 Zn finger 449..469 CDD:275368 1/19 (5%)
zf-H2C2_2 461..486 CDD:290200 4/24 (17%)
C2H2 Zn finger 477..497 CDD:275368 3/25 (12%)
C2H2 Zn finger 505..525 CDD:275368 3/40 (8%)
zf-H2C2_2 517..542 CDD:290200 8/49 (16%)
C2H2 Zn finger 533..553 CDD:275368 4/34 (12%)
C2H2 Zn finger 561..581 CDD:275368 9/19 (47%)
zf-H2C2_2 574..596 CDD:290200 12/21 (57%)
C2H2 Zn finger 589..609 CDD:275368 9/20 (45%)
zf-H2C2_2 601..626 CDD:290200 8/25 (32%)
C2H2 Zn finger 617..637 CDD:275368 4/19 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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