DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF7

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001336738.1	Gene:	ZNF7 / 7553	HGNCID:	13139	Length:	707	Species:	Homo sapiens

Alignment Length:	967	Identity:	197/967 - (20%)
Similarity:	298/967 - (30%)	Gaps:	386/967 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ASVDGMDAF--FKDR--AQAEHILQEWVRRREPVCELDIRDSGGVYA----KT------------ 158
            :||.|:..|  ||..  ::.|...:.||        ||::.:.|..|    ||
Human    59 SSVAGLAGFLVFKPELISRLEQGEEPWV--------LDLQGAEGTEAPRTSKTDSTIRTENEQAC 115

  Fly   159 ---PLQRGTRYGPFPMKLSHQPND-PQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEA 219
               .:.:...||.. :::|  |.| ||          |.......|...||       |..:|..
Human   116 EDMDILKSESYGTV-VRIS--PQDFPQ----------NPGFGDVSDSEVWL-------DSHLGSP 160

  Fly   220 NLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSG 284
            .|:.   .|:.:  .|..:|  .|.||      |....:|...|.|.|.::
Human   161 GLKV---TGFTF--QNNCLN--EETVV------PKTFTKDAPQGCKELGSS-------------- 198

  Fly   285 AKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDI-RCEVCDKVY 348
                 |....|.:.:.:...|.....:|..|..:.:|     ||....:.|...| ||:.|.|..
Human   199 -----GLDCQPLESQGESAEGMSQRCEECGKGIRATS-----DIALHWEINTQKISRCQECQKKL 253

  Fly   349 PDLDLLDDHLIGAHHFKQDEFPCKQC--ALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPS 411
            .|. |...|....|..|  .:.|.:|  ..|.|.:  |.:|:.| |...:.:.|..|.|.|...|
Human   254 SDC-LQGKHTNNCHGEK--PYECAECGKVFRLCSQ--LNQHQRI-HTGEKPFKCTECGKAFRLSS 312

  Fly   412 NLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRM 476
            .|.:|.| .|.|.:.:.|.||||.||.||.|..||.||:..:|:.|..|.||::|.|.|.||:|.
Human   313 KLIQHQR-IHTGEKPYRCEECGKAFGQSSSLIHHQRIHTGERPYGCRECGKAFSQQSQLVRHQRT 376

  Fly   477 HATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATA 541
            | |......|.:|.::||..::|.:|::.  .||.
Human   377 H-TGERPYPCKECGKAFSQSSTLAQHQRM--HTGE------------------------------ 408

  Fly   542 TSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNI 606
                .|...::|:|.|..|...:.|:..|      |:...
Human   409 ----KAQILKASDSPSLVAHQRIHAVEKP------FKCDE------------------------- 438

  Fly   607 PMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPL 671
                        ||        .||                :...::::.:|:...|:..|....
Human   439 ------------CG--------KAF----------------RWISRLSQHQLIHTGEKPYKCNKC 467

  Fly   672 VQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPP 736
            .:||      ..||..|:.:...|
Human   468 TKAF------GCSSRLIRHQRTHT----------------------------------------- 485

  Fly   737 PADTPSGGDGPLDLSICRKRSA-GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAE 800
                   |:.|.....|.|... ||        :|:.|:   |:|..|    :|........:..
Human   486 -------GEKPFKCDECGKGFVQGS--------HLIQHQ---RIHTGE----KPYVCNDCGKAFS 528

  Fly   801 SSTS----QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSAL 861
            .|:|    |:.|||..|                                            :..|
Human   529 QSSSLIYHQRIHKGEKP--------------------------------------------YECL 549

  Fly   862 ASGPTLP-QTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGS 925
            ..|.... .|..|.|    :.::....|:.|...|:                       .||..|
Human   550 QCGKAFSMSTQLTIH----QRVHTGERPYKCNECGK-----------------------AFSQNS 587

  Fly   926 VV--------GLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQ--------------------- 961
            .:        |:|.   |.|..|||.|.||:.|..|.|.||..|
Human   588 TLFQHQIIHAGVKP---YECSECGKAFSRSSYLIEHQRIHTRAQWFYEYGNALEGSTFVSRKKVN 649

  Fly   962 ----PYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKH 1014
                .:.|:.|::.|...|:|..|.| ||..|:|::|..|.::|.:.:.|.:|.|.|
Human   650 TIKKLHQCEDCEKIFRWRSHLIIHQR-IHTGEKPYKCNDCGKAFNRSSRLTQHQKIH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	28/141 (20%)
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	7/22 (32%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	19/41 (46%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	12/19 (63%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	9/86 (10%)
		COG5048	935..>1028	CDD:227381	32/105 (30%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	8/48 (17%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF7	NP_001336738.1	KRAB	25..86	CDD:214630	7/26 (27%)
		PHA02693	64..>137	CDD:333460	16/83 (19%)
		COG5048	239..696	CDD:227381	145/711 (20%)
		C2H2 Zn finger	246..265	CDD:275368	6/19 (32%)
		C2H2 Zn finger	273..293	CDD:275368	7/22 (32%)
		C2H2 Zn finger	301..321	CDD:275368	8/20 (40%)
		C2H2 Zn finger	329..349	CDD:275368	12/19 (63%)
		C2H2 Zn finger	357..377	CDD:275368	10/19 (53%)
		C2H2 Zn finger	385..405	CDD:275368	6/21 (29%)
		C2H2 Zn finger	436..456	CDD:275368	5/80 (6%)
		C2H2 Zn finger	464..484	CDD:275368	5/25 (20%)
		C2H2 Zn finger	492..512	CDD:275368	7/30 (23%)
		C2H2 Zn finger	520..540	CDD:275368	3/19 (16%)
		C2H2 Zn finger	548..568	CDD:275368	5/23 (22%)
		C2H2 Zn finger	576..596	CDD:275368	5/42 (12%)
		C2H2 Zn finger	604..624	CDD:275368	10/19 (53%)
		C2H2 Zn finger	657..677	CDD:275368	7/20 (35%)
		C2H2 Zn finger	685..705	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000