DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and KLF10

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_005646.1 Gene:KLF10 / 7071 HGNCID:11810 Length:480 Species:Homo sapiens


Alignment Length:519 Identity:116/519 - (22%)
Similarity:188/519 - (36%) Gaps:139/519 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   549 PRES-------SESSSSAAAAAVAAMS----------------TP--------------PNPFLM 576
            |:||       :|.|...|..|:.:||                ||              |:    
Human    23 PKESMYSWNKTAEKSDFEAVEALMSMSCSWKSDFKKYVENRPVTPVSDLSEEENLLPGTPD---- 83

  Fly   577 FRTAPSF--FPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGF 639
            |.|.|:|  .|.:.|..|.|....|.:.|....:.| |:..|  ...|.|.:|... ::|.|...
Human    84 FHTIPAFCLTPPYSPSDFEPSQVSNLMAPAPSTVHF-KSLSD--TAKPHIAAPFKE-EEKSPVSA 144

  Fly   640 LKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQ 704
            .|...:::.:..:.|....:...:....|...:..::......|:.|:::..             
Human   145 PKLPKAQATSVIRHTADAQLCNHQTCPMKAASILNYQNNSFRRRTHLNVEAA------------- 196

  Fly   705 DDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSF-FTAPAED 768
              .|..|....:|::.:.|  |.::        ||            :..|.||..: |:.|:.:
Human   197 --RKNIPCAAVSPNRSKCE--RNTV--------AD------------VDEKASAALYDFSVPSSE 237

  Fly   769 NLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSP----SP 829
            .::.             |.||         |..|..|||...|.|.   .::.|:.|.|    ..
Human   238 TVIC-------------RSQP---------APVSPQQKSVLVSPPA---VSAGGVPPMPVICQMV 277

  Fly   830 PTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPG 894
            |..|...:.:|......|:...|...   ..:..|..:|:....|  ::.:.:.:|..|.:..|.
Human   278 PLPANNPVVTTVVPSTPPSQPPAVCP---PVVFMGTQVPKGAVMF--VVPQPVVQSSKPPVVSPN 337

  Fly   895 GRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR---YSCKF--CGKVFPRSANLTRHL 954
            |.|            .:|..|.|....||..|.......|   :.|..  |||.:.:|::|..|.
Human   338 GTR------------LSPIAPAPGFSPSAAKVTPQIDSSRIRSHICSHPGCGKTYFKSSHLKAHT 390

  Fly   955 RTHTGEQPYPC--KYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHES 1016
            ||||||:|:.|  |.|:|.|:.|..|.|| |..|..|:.|.|.:|||.|.:..:|.:|.::|.|
Human   391 RTHTGEKPFSCSWKGCERRFARSDELSRH-RRTHTGEKKFACPMCDRRFMRSDHLTKHARRHLS 453

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368
C2H2 Zn finger 371..392 CDD:275368
SFP1 <391..479 CDD:227516
C2H2 Zn finger 400..421 CDD:275368
SUF4-like 403..>445 CDD:411020
C2H2 Zn finger 403..421 CDD:411020
C2H2 Zn finger 429..449 CDD:275368
C2H2 Zn finger 457..477 CDD:275368
C2H2 Zn finger 486..504 CDD:275368
PTZ00121 <641..>728 CDD:173412 10/86 (12%)
COG5048 935..>1028 CDD:227381 36/86 (42%)
zf-C2H2 935..957 CDD:395048 8/23 (35%)
C2H2 Zn finger 937..957 CDD:275368 8/21 (38%)
zf-H2C2_2 949..973 CDD:404364 13/25 (52%)
C2H2 Zn finger 965..986 CDD:275368 10/22 (45%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
KLF10NP_005646.1 zf-C2H2 369..393 CDD:278523 8/23 (35%)
COG5048 374..>424 CDD:227381 23/50 (46%)
C2H2 Zn finger 374..393 CDD:275368 7/18 (39%)
zf-H2C2_2 385..412 CDD:290200 14/26 (54%)
C2H2 Zn finger 401..423 CDD:275368 10/22 (45%)
zf-H2C2_2 415..438 CDD:290200 11/23 (48%)
zf-C2H2 429..451 CDD:278523 8/21 (38%)
C2H2 Zn finger 431..451 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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