DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp442

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_011238043.1	Gene:	Zfp442 / 668923	MGIID:	3651999	Length:	673	Species:	Mus musculus

Alignment Length:	875	Identity:	180/875 - (20%)
Similarity:	278/875 - (31%)	Gaps:	295/875 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 HQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVN 239
            |.|.:...:.:.|.||....:|......|...|:.:.|....|    ...|:.|...||..:|:.
Mouse    56 HNPEEHFQSSRRHGRHEKSHIEEKPSEFTQCGKVFAYQSHPQG----HQQIHTGEKPYEVIQYLE 116

  Fly   240 AGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDN 304
            |.:.       .|.:|:::....|.|.........|.....|....|....|.
Mouse   117 AFAY-------HSSLQIHKRTHGGDKHYKINECGKAFACHNSLQRYKRVHTGE------------ 162

  Fly   305 GSLYSGDEFSKDKKNSSLIREGDIDFT--DDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQD 367
             .||..::...|....|.:::.:...|  ..::|.|..|      |.:|.:..     ..|..:.
Mouse   163 -KLYECNQCGTDFAQHSHLQQHERMHTVKCKQSGKDFAC------YTNLQIYQ-----RTHTGEK 215

  Fly   368 EFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPEC 432
            .:.|..|...|.|...|.:||.| |...:.|.|..|.|.|...|:||.|.|. |.|.:.:.|.:|
Mouse   216 PYECIFCDKTFIHHSHLERHERI-HTGEKPYECNQCGKAFSQNSSLQLHKRT-HTGEKPYECKQC 278

  Fly   433 GKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLT 497
            ||:|...|||:||:..|...|.:.|:.|.||:...|:|.:|||.| |.....:|::|:::|:...
Mouse   279 GKSFACQSGLQQHKKTHHGEKSYECKRCGKAFACQSDLQQHKRTH-TGEKSYECNQCDKAFALRC 342

  Fly   498 SLTKHKKF--------CDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLA----ATATSTCPAPPR 550
            .|.:|::.        |:..|....::.|..| |:..|....|::.:..    |..||.......
Mouse   343 HLRRHQRIHTVEKPYKCNQCGKFFAQSNHFVR-HKRTHTGEKPYECNQCDKAFACQTSLLYHKRT 406

  Fly   551 ESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPM 615
            .|.|.                                             |:..|
Mouse   407 HSGEK---------------------------------------------LYVCN---------- 416

  Fly   616 DLGCGGPEITSPVSAFDQKL-----PFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAF 675
              .||...:........::.     |||..:.:.:.:|....:|.|. ....|:..:.|...:||
Mouse   417 --ECGKAFVLQSYLQIHKRTHTGEKPFGCDQCDKAFAQNSHLLTHKR-THTGEKPYECEQCGKAF 478

  Fly   676 EGEEDESRSSLDIKGKLEDTRNDSKSEE----------QDDMKQEPERVSTPDQQQAEDDRKSID 730
                 .|.|:|.:..|   |....|..|          |..: |:.:|..|
Mouse   479 -----ASNSNLQVHKK---THTGEKPYECKQCGKAFGFQSGL-QKHKRTHT-------------- 520

  Fly   731 IMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKS 795
                         |:.|.:.:.|.|..|       .:.:|:.|:
Mouse   521 -------------GEKPYECNQCDKAFA-------CQASLLNHK--------------------- 544

  Fly   796 HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSA 860
                      :||.|..|                        ...||.|       .||.. ||.
Mouse   545 ----------RSHTGEKP------------------------YECSECG-------KAFVL-HSY 567

  Fly   861 LASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGS 925
            |       |.|...|                                   ..::|
Mouse   568 L-------QIHKRIH-----------------------------------TGEKP---------- 580

  Fly   926 VVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKER 990
                     :.|..|.|.|.|:..|.:|.|.|||::||.||.|.:||:..||||.|.|. |..|:
Mouse   581 ---------FECDQCDKAFARNTLLLKHKRIHTGQKPYGCKQCGKAFANHSNLQVHKRT-HTGEK 635

  Fly   991 PFRCELCDRSFGQQTNLDRHVK-KHESEGN 1019
            |:.|:.|.:.|..|:.|..|.: :|..|.|
Mouse   636 PYECKHCGKPFKCQSGLQYHKRTQHIQERN 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	16/77 (21%)
		C2H2 Zn finger	341..363	CDD:275368	3/21 (14%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	18/41 (44%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	18/96 (19%)
		COG5048	935..>1028	CDD:227381	36/86 (42%)
		zf-C2H2	935..957	CDD:395048	8/21 (38%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	11/20 (55%)
		C2H2 Zn finger	994..1014	CDD:275368	6/20 (30%)
Zfp442	XP_011238043.1	KRAB	10..50	CDD:366587
		C2H2 Zn finger	83..103	CDD:275368	4/23 (17%)
		C2H2 Zn finger	140..159	CDD:275368	3/18 (17%)
		C2H2 Zn finger	167..183	CDD:275368	2/15 (13%)
		C2H2 Zn finger	191..211	CDD:275368	5/30 (17%)
		COG5048	215..595	CDD:227381	114/608 (19%)
		C2H2 Zn finger	219..239	CDD:275368	8/20 (40%)
		C2H2 Zn finger	247..267	CDD:275368	9/20 (45%)
		C2H2 Zn finger	275..295	CDD:275368	10/19 (53%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		C2H2 Zn finger	331..351	CDD:275368	5/19 (26%)
		C2H2 Zn finger	359..379	CDD:275368	5/20 (25%)
		C2H2 Zn finger	387..407	CDD:275368	3/19 (16%)
		C2H2 Zn finger	415..435	CDD:275368	3/31 (10%)
		C2H2 Zn finger	443..463	CDD:275368	3/20 (15%)
		C2H2 Zn finger	471..491	CDD:275368	7/27 (26%)
		C2H2 Zn finger	499..519	CDD:275368	3/20 (15%)
		C2H2 Zn finger	527..547	CDD:275368	5/57 (9%)
		C2H2 Zn finger	555..575	CDD:275368	10/34 (29%)
		SFP1	<577..660	CDD:227516	34/102 (33%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		C2H2 Zn finger	611..631	CDD:275368	11/20 (55%)
		C2H2 Zn finger	639..658	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000