DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF732

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001131080.1	Gene:	ZNF732 / 654254	HGNCID:	37138	Length:	585	Species:	Homo sapiens

Alignment Length:	761	Identity:	148/761 - (19%)
Similarity:	214/761 - (28%)	Gaps:	364/761 - (47%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLI---GAHHFK---------------------QDEFPCKQCALRFCH 380
            :|.|..||:......:...|   |..|||                     :..:.|::|...|..
Human   142 QCNVHVKVFSTFSNSNQRRIRHTGEKHFKECGKSFQKFSDLTQHQGIHAGEKPYTCEECGKDFKW 206

  Fly   381 RPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQH 445
            ..:..::|.| |...:.::||.|..:|...||..:|  ..|.|.:.:...||||.|..||.|.:|
Human   207 YLIFNEYEII-HTGEKPFTCEECGNIFTTSSNFAKH--KVHTGEKSYKYEECGKAFNRSSTLTKH 268

  Fly   446 QHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTG 510
            :.||:..|||.||.|.|..|..||:.:||::| |.....||.:|.:.|:..|:||||.:.  .||
Human   269 KRIHAEEKPFTCEECGKIITSSSNVAKHKKIH-TGEKLYKCQECGKVFNRSTTLTKHNRI--HTG 330

  Fly   511 PGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFL 575
            ..||                             ||..
Human   331 EKPY-----------------------------TCEE---------------------------- 338

  Fly   576 MFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFL 640
                                                       ||        .||.:.
Human   339 -------------------------------------------CG--------KAFSRS------ 346

  Fly   641 KGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQD 705
                      ..:.|.:.:...|:..|.|...:||.
Human   347 ----------SVLNEHKRIHTGEKPYKCEQCGKAFR----------------------------- 372

  Fly   706 DMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNL 770
                         |....:..|||..            |:.|.....|.|  |.|.||...|
Human   373 -------------QSATLNKHKSIHT------------GEKPYTCEECGK--AFSRFTTLNE--- 407

  Fly   771 MLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGG 835
              |:   |:|..|    :|.|..:...:...||....||
Human   408 --HK---RIHTGE----RPHKCEECGKAFGWSTDLNKHK-------------------------- 437

  Fly   836 ELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIE 900
                                                          |..:|
Human   438 ----------------------------------------------IIHTG-------------- 442

  Fly   901 ALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPC 965
                        ::|                   |.|:.|||.|..||.|::|.:.||||:||.|
Human   443 ------------EKP-------------------YKCEECGKAFGWSAYLSKHKKIHTGEKPYRC 476

  Fly   966 KYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE--------GNNFR 1022
            :.|.:||..|..|.:| :.||..|:|:.||.|.::||..|.|.:|.|.|..|        |..||
Human   477 EECGKAFLCSRALNKH-KTIHTGEKPYECEECGKAFGWSTYLSKHKKIHTGEKPYRCEECGKAFR 540

  Fly  1023 DS---------------PSSSGIAEREEYFDDIRKFMNRVYTPNSL 1053
            .|               |...|..:..::...:.:. |::||...|
Human   541 RSRVLNKYKTIHTGDKTPKCKGCGKAFKWSSYLNQH-NKIYTGEKL 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/24 (25%)
		C2H2 Zn finger	371..392	CDD:275368	5/20 (25%)
		SFP1	<391..479	CDD:227516	34/87 (39%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	5/17 (29%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	7/86 (8%)
		COG5048	935..>1028	CDD:227381	43/115 (37%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	11/23 (48%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	9/19 (47%)
ZNF732	NP_001131080.1	KRAB	4..62	CDD:214630
		KRAB	4..43	CDD:279668
		COG5048	130..542	CDD:227381	141/715 (20%)
		C2H2 Zn finger	143..163	CDD:275368	5/19 (26%)
		C2H2 Zn finger	170..189	CDD:275368	1/18 (6%)
		C2H2 Zn finger	225..244	CDD:275368	7/20 (35%)
		C2H2 Zn finger	253..272	CDD:275368	9/18 (50%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		zf-H2C2_2	292..317	CDD:290200	9/25 (36%)
		C2H2 Zn finger	308..328	CDD:275368	8/21 (38%)
		zf-H2C2_2	321..345	CDD:290200	14/133 (11%)
		C2H2 Zn finger	336..356	CDD:275368	6/114 (5%)
		zf-H2C2_2	349..373	CDD:290200	6/65 (9%)
		C2H2 Zn finger	364..384	CDD:275368	6/61 (10%)
		zf-H2C2_2	377..401	CDD:290200	8/37 (22%)
		C2H2 Zn finger	392..412	CDD:275368	9/29 (31%)
		zf-H2C2_2	405..427	CDD:290200	7/33 (21%)
		C2H2 Zn finger	420..440	CDD:275368	5/91 (5%)
		zf-H2C2_2	432..455	CDD:290200	10/139 (7%)
		C2H2 Zn finger	448..468	CDD:275368	9/19 (47%)
		zf-H2C2_2	460..483	CDD:290200	10/22 (45%)
		C2H2 Zn finger	476..496	CDD:275368	7/20 (35%)
		zf-H2C2_2	488..511	CDD:290200	9/23 (39%)
		C2H2 Zn finger	504..524	CDD:275368	9/19 (47%)
		zf-H2C2_2	516..541	CDD:290200	7/24 (29%)
		C2H2 Zn finger	532..552	CDD:275368	4/19 (21%)
		C2H2 Zn finger	560..579	CDD:275368	2/19 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000