DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ham and ZNF723

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:XP_024307421.1 Gene:ZNF723 / 646864 HGNCID:32286 Length:547 Species:Homo sapiens


Alignment Length:683 Identity:137/683 - (20%)
Similarity:196/683 - (28%) Gaps:327/683 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:...||:......:...|  .|...:.|.||:|...||....|.|||. :|..:..|.||.|.
Human   146 QCDKYVKVFHKFSSSNSQKI--RHTGNNSFKCKECGKSFCMLSHLTKHER-NHTRVNCYKCEECG 207

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|..||.|..|.| .|.|.:.:.|.||||.|..||.|..|:.||:..||:.||.|.|.:..||:
Human   208 KAFSVPSKLNNHKR-IHTGEKPYKCEECGKAFNVSSSLNNHKRIHTGEKPYKCEECGKTFNMFSS 271

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQ 534
            |..|||:| |.....||.:|.::|:..:||..||:.  .||..||:.:.                
Human   272 LNNHKRIH-TGEKPYKCKECGKAFNVFSSLNNHKRI--HTGEKPYKCEE---------------- 317

  Fly   535 PHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQN 599
                                                                             
Human   318 ----------------------------------------------------------------- 317

  Fly   600 PLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEE 664
                               ||        .||:|.          |....:.::...|.::|.||
Human   318 -------------------CG--------KAFNQP----------SHLATHKRIHTGEKLYKCEE 345

  Fly   665 KLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSI 729
                                                                             
Human   346 ----------------------------------------------------------------- 345

  Fly   730 DIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFE-----AERGQP 789
                                   |.|..:.|       .::..|:   |:|..|     .|.|:.
Human   346 -----------------------CGKAFSQS-------SHITTHK---RIHTGEKPYKCEECGKA 377

  Fly   790 LKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAF 854
            .|:     |...:|.::.|.|..|............|                            
Human   378 FKV-----SVHLTTHKRIHTGEKPYKCEECGKAFNQS---------------------------- 409

  Fly   855 AADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPV 919
                |||.       ||...|                                   ..:||    
Human   410 ----SALT-------THKIIH-----------------------------------TGERP---- 424

  Fly   920 KFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRN 984
                           |.||.|||.|.:|:.||:|...||.|:||.|:.|.:||:..|.|.:| :.
Human   425 ---------------YKCKQCGKGFSQSSTLTKHKIIHTKEKPYKCEECGKAFNQYSTLNKH-KI 473

  Fly   985 IHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ||.:|:|::||.|.::|.:.:.|:||...|..|
Human   474 IHAREKPYKCEECGKAFNKSSILNRHKIIHTKE 506

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 4/21 (19%)
C2H2 Zn finger 371..392 CDD:275368 9/20 (45%)
SFP1 <391..479 CDD:227516 39/87 (45%)
C2H2 Zn finger 400..421 CDD:275368 10/20 (50%)
SUF4-like 403..>445 CDD:411020 19/41 (46%)
C2H2 Zn finger 403..421 CDD:411020 8/17 (47%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 10/19 (53%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 5/86 (6%)
COG5048 935..>1028 CDD:227381 36/83 (43%)
zf-C2H2 935..957 CDD:395048 11/21 (52%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 11/23 (48%)
C2H2 Zn finger 965..986 CDD:275368 7/20 (35%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
ZNF723XP_024307421.1 KRAB 4..64 CDD:214630
COG5048 156..504 CDD:227381 132/669 (20%)
C2H2 Zn finger 175..195 CDD:275368 9/20 (45%)
C2H2 Zn finger 203..223 CDD:275368 10/20 (50%)
C2H2 Zn finger 231..251 CDD:275368 10/19 (53%)
C2H2 Zn finger 259..279 CDD:275368 10/19 (53%)
C2H2 Zn finger 287..307 CDD:275368 7/21 (33%)
C2H2 Zn finger 315..335 CDD:275368 6/137 (4%)
C2H2 Zn finger 343..363 CDD:275368 7/117 (6%)
C2H2 Zn finger 371..391 CDD:275368 5/24 (21%)
C2H2 Zn finger 399..419 CDD:275368 6/58 (10%)
C2H2 Zn finger 427..447 CDD:275368 10/19 (53%)
C2H2 Zn finger 455..475 CDD:275368 7/20 (35%)
C2H2 Zn finger 483..503 CDD:275368 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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