DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp808

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001034328.2	Gene:	Zfp808 / 630579	MGIID:	3704127	Length:	753	Species:	Mus musculus

Alignment Length:	707	Identity:	175/707 - (24%)
Similarity:	246/707 - (34%)	Gaps:	207/707 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCS 404
            :|:.|||.:.:...|..|:  ..|..:..:.|.||...|..:..|.||..| |...:.|.|..|.
Mouse   218 KCDQCDKAFSEKCNLQTHI--RIHTGEKPYKCDQCDKTFSEKCHLQKHIRI-HTGEKPYKCNQCD 279

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|...|.||.| |..|.|.:.:.|.:|.|.|.....|:.|:..|:..|||.|..|.||::|:|.
Mouse   280 KAFSQYSTLQTH-RRTHTGEKPYKCNQCDKAFSQYGNLQTHRRTHTGEKPFKCNQCDKAFSQYST 343

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---HHQHPHQHPL 531
            |..|:|.| |.....||::|:::||...||.:|.:.  .||..||:....|:   |:.|.|.|..
Mouse   344 LQTHRRTH-TGEKPYKCNQCDKAFSEKCSLQRHIRI--HTGEKPYKCNQCNKAFSHNYHLHIHRR 405

  Fly   532 PHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFL 596
            .|                                   |...|:...:...:|...||
Mouse   406 TH-----------------------------------TGEKPYKCNQCDKAFSIHFP-------- 427

  Fly   597 PQN--PLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKL-------------PFGFLKGENSE 646
            .||  ..|....|  :..|..|            .||.:|.             |:...:.:.:.
Mouse   428 LQNHKRTHTGEKP--YKCNQCD------------KAFSEKCHLQNHIRIHTGEKPYKCNQCDKAF 478

  Fly   647 SQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEP 711
            ||.:...|.:. :...|:..|.....:||     ...|:|....:........|..:.|
Mouse   479 SQYFSLQTHRR-IHTGEKPFKCNQCDKAF-----SQYSTLQTHRRTHTGEKPFKCNQCD------ 531

  Fly   712 ERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFM 776
                           |:....||.........|:.|...|.|.|  |.|.:     :.|..||
Mouse   532 ---------------KAFSKHSTLQSHRRTHSGEKPFKCSQCDK--AFSQY-----NTLQAHR-- 572

  Fly   777 PRLHEFEAERGQPLKMRKSHSS-AESSTSQKS---HKGSSPTPTPTASPGLTPSPSPPTSAGGEL 837
             |.|..|    :|.|..:...: :|....||.   |.|..|.......
Mouse   573 -RTHSGE----KPFKCDQCDKAFSEKCNLQKHIRIHTGEKPYKCNQCD----------------- 615

  Fly   838 SSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEAL 902
                                 .|.:...|| |||        ..|:....||.|....:
Mouse   616 ---------------------KAFSQYNTL-QTH--------RRIHTGEKPFKCNQCDK------ 644

  Fly   903 LAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-------YSCKFCGKVFPRSANLTRHLRTHTGE 960
                             .||..|.  |:|..|       :.|..|.|||.:.:||..|.||||||
Mouse   645 -----------------AFSRHST--LQTHRRTHTGEKPFKCNQCDKVFSQYSNLQTHRRTHTGE 690

  Fly   961 QPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            :||.|..||:|||:..|||.||| ||..|:|::|..||::|.|.:||..|.|.|..:
Mouse   691 KPYKCDQCDKAFSMKCNLQNHVR-IHTGEKPYKCNQCDKAFFQYSNLHIHRKTHTGQ 746

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	6/21 (29%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	33/87 (38%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	15/41 (37%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	6/19 (32%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	42/83 (51%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	15/23 (65%)
		C2H2 Zn finger	965..986	CDD:275368	12/20 (60%)
		C2H2 Zn finger	994..1014	CDD:275368	9/19 (47%)
Zfp808	NP_001034328.2	KRAB	4..>45	CDD:214630
		KRAB	4..40	CDD:279668
		COG5048	<130..284	CDD:227381	21/68 (31%)
		C2H2 Zn finger	135..155	CDD:275368
		C2H2 Zn finger	163..183	CDD:275368
		zf-H2C2_2	175..199	CDD:290200
		C2H2 Zn finger	191..211	CDD:275368
		zf-H2C2_2	203..227	CDD:290200	4/8 (50%)
		C2H2 Zn finger	219..239	CDD:275368	6/21 (29%)
		zf-H2C2_2	231..255	CDD:290200	6/25 (24%)
		C2H2 Zn finger	247..267	CDD:275368	8/20 (40%)
		zf-H2C2_2	259..284	CDD:290200	10/25 (40%)
		C2H2 Zn finger	275..295	CDD:275368	9/20 (45%)
		zf-H2C2_2	288..312	CDD:290200	10/24 (42%)
		C2H2 Zn finger	303..323	CDD:275368	6/19 (32%)
		zf-H2C2_2	315..340	CDD:290200	10/24 (42%)
		COG5048	327..728	CDD:227381	132/574 (23%)
		C2H2 Zn finger	331..351	CDD:275368	9/19 (47%)
		zf-H2C2_2	344..367	CDD:290200	8/23 (35%)
		C2H2 Zn finger	359..379	CDD:275368	7/21 (33%)
		zf-H2C2_2	371..396	CDD:290200	8/26 (31%)
		C2H2 Zn finger	387..407	CDD:275368	5/19 (26%)
		C2H2 Zn finger	415..435	CDD:275368	5/27 (19%)
		zf-H2C2_2	428..451	CDD:290200	7/36 (19%)
		C2H2 Zn finger	443..463	CDD:275368	5/31 (16%)
		zf-H2C2_2	455..480	CDD:290200	1/24 (4%)
		C2H2 Zn finger	471..491	CDD:275368	3/20 (15%)
		zf-H2C2_2	483..508	CDD:290200	5/30 (17%)
		C2H2 Zn finger	499..519	CDD:275368	4/24 (17%)
		zf-H2C2_2	512..535	CDD:290200	4/43 (9%)
		C2H2 Zn finger	527..547	CDD:275368	4/40 (10%)
		zf-H2C2_2	540..564	CDD:290200	6/25 (24%)
		C2H2 Zn finger	555..575	CDD:275368	9/29 (31%)
		zf-H2C2_2	568..591	CDD:290200	8/29 (28%)
		C2H2 Zn finger	583..603	CDD:275368	3/19 (16%)
		zf-H2C2_2	595..620	CDD:290200	6/62 (10%)
		C2H2 Zn finger	611..631	CDD:275368	6/66 (9%)
		zf-H2C2_2	624..648	CDD:290200	9/55 (16%)
		C2H2 Zn finger	639..659	CDD:275368	7/44 (16%)
		zf-H2C2_2	652..676	CDD:290200	8/23 (35%)
		C2H2 Zn finger	667..687	CDD:275368	9/19 (47%)
		zf-H2C2_2	679..703	CDD:290200	15/23 (65%)
		C2H2 Zn finger	695..715	CDD:275368	12/20 (60%)
		zf-H2C2_2	707..730	CDD:290200	13/23 (57%)
		C2H2 Zn finger	723..743	CDD:275368	9/19 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000