DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	1061	Identity:	216/1061 - (20%)
Similarity:	310/1061 - (29%)	Gaps:	484/1061 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 LHHLDLSARSQGFNPLSEQIEDSFAA----RHHLPQQEPVEGSPPRRDHLDIQDQELLHHPNHFH 89
            |||             .|..|::.|.    :.||...|.|  |.|      .|.||:     ||.
Human   116 LHH-------------PESGEEAVAVVEDFQRHLSGSEEV--SAP------AQKQEM-----HFE 154

  Fly    90 QQNQ--RQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREPVCELDIRDSG 152
            :...  ..:..|||.|||..|:.
Human   155 ETTALGTTKESPPTSPLSGGSAP------------------------------------------ 177

  Fly   153 GVYAKTPLQRGTRY---GPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDD 214
            |.:.:.|...||.:   |.|....|..|..||:   .:|....|        :|.|:.:|  ..|
Human   178 GAHLEPPYDPGTHHLPSGDFAQCTSPVPTLPQV---GNSGDQAG--------ATVLRMVR--PQD 229

  Fly   215 CIGEANL---------------QSYINAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGG 264
            .:...:|               |..:....:....:...:...|.::.|...:|.|   :|..|
Human   230 TVAYEDLSVDYTQKKWKSLTLSQRALQWNMMPENHHSMASLAGENMMKGSELTPKQ---EFFKG- 290

  Fly   265 KVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEF----------SKDKKN 319
                           :.||...|||.....|         |:..:||..          :.|::.
Human   291 ---------------SESSNRTSGGLFGVVP---------GAAETGDVCEDTFKELEGQTSDEEG 331

  Fly   320 SSLIREGD-IDFTDDENGFDIRCEVCDKVYPDLDLLDDHL-IGAH---------H---FK-QDEF 369
            |.|  |.| ::.||:           ||.....|..|.:. :|.|         |   .| |..:
Human   332 SRL--ENDFLEITDE-----------DKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGVLKGQKSY 383

  Fly   370 PCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGK 434
            .|.:|...|.....||.|:.| |...:.|.|..|.|.|...|.|..|:|. |.|.:.:.|.||||
Human   384 RCDECGKAFNRSSHLIGHQRI-HTGEKPYECNECGKTFRQTSQLIVHLRT-HTGEKPYECSECGK 446

  Fly   435 TFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSL 499
            .:..||.|.|||.:|:..||:.|..|:||:||.|.|..|:|.| |.....:|::|.::|....||
Human   447 AYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDHQRTH-TGEKPYECNECGEAFIRSKSL 510

  Fly   500 TKHKKFCDSTGPGPYRNQHVNR---------HHQHPHQHPLPHQPHLAATATSTCPAPPRESSES 555
            .:|:..  .||..||:.....|         .||..|....|::......|.|......|..|
Human   511 ARHQVL--HTGKKPYKCNECGRAFCSNRNLIDHQRIHTGEKPYECSECGKAFSRSKCLIRHQS-- 571

  Fly   556 SSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCG 620
                                                         ||....|...|:      ||
Human   572 ---------------------------------------------LHTGEKPYKCSE------CG 585

  Fly   621 GPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSS 685
                    .||:|          ||:                        |:
Human   586 --------KAFNQ----------NSQ------------------------LI------------- 595

  Fly   686 LDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDL 750
                                    |.||:.|                           |:.|.:.
Human   596 ------------------------EHERIHT---------------------------GEKPFEC 609

  Fly   751 SICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTP 815
            |.|.|    :|..:..   |:.|:   |||..|    :|.|.    :....|.:|.||
Human   610 SECGK----AFGLSKC---LIRHQ---RLHTGE----KPYKC----NECGKSFNQNSH------- 649

  Fly   816 TPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLE 880
                                                                         |::.
Human   650 -------------------------------------------------------------LIIH 653

  Fly   881 EIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFP 945
            :...:|                          ::|                   |.|..|||||.
Human   654 QRIHTG--------------------------EKP-------------------YECNECGKVFS 673

  Fly   946 RSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRH 1010
            .|::|..|.||||||:||.|..|.:|||.||.|..|.| :|..|:|:.|..|.::|.|::..:.|
Human   674 YSSSLMVHQRTHTGEKPYKCNDCGKAFSDSSQLIVHQR-VHTGEKPYECSECGKAFSQRSTFNHH 737

  Fly  1011 VKKHESEGNNFRDSPSSSGIA 1031
            .:.|..|        .|||:|
Human   738 QRTHTGE--------KSSGLA 750

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	20/139 (14%)
		C2H2 Zn finger	341..363	CDD:275368	6/31 (19%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	7/86 (8%)
		COG5048	935..>1028	CDD:227381	38/92 (41%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708	17/70 (24%)
		SCAN	51..138	CDD:280241	8/34 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215		18/102 (18%)
		KRAB_A-box	231..270	CDD:143639	2/38 (5%)
		COG5048	380..738	CDD:227381	137/653 (21%)
		zf-C2H2	383..405	CDD:278523	7/22 (32%)
		C2H2 Zn finger	385..405	CDD:275368	7/20 (35%)
		zf-H2C2_2	401..422	CDD:290200	8/21 (38%)
		C2H2 Zn finger	413..433	CDD:275368	8/20 (40%)
		zf-H2C2_2	426..450	CDD:290200	10/24 (42%)
		C2H2 Zn finger	441..461	CDD:275368	11/19 (58%)
		zf-H2C2_2	453..478	CDD:290200	11/24 (46%)
		C2H2 Zn finger	469..489	CDD:275368	10/19 (53%)
		zf-H2C2_2	482..506	CDD:290200	8/24 (33%)
		C2H2 Zn finger	497..517	CDD:275368	6/21 (29%)
		zf-H2C2_2	509..532	CDD:290200	8/24 (33%)
		C2H2 Zn finger	525..545	CDD:275368	3/19 (16%)
		zf-H2C2_2	537..562	CDD:290200	5/24 (21%)
		C2H2 Zn finger	553..573	CDD:275368	4/66 (6%)
		zf-H2C2_2	566..590	CDD:290200	10/84 (12%)
		C2H2 Zn finger	581..601	CDD:275368	12/104 (12%)
		zf-H2C2_2	594..616	CDD:290200	10/89 (11%)
		C2H2 Zn finger	609..629	CDD:275368	7/29 (24%)
		zf-H2C2_2	622..646	CDD:290200	9/34 (26%)
		C2H2 Zn finger	637..657	CDD:275368	5/91 (5%)
		zf-H2C2_2	649..674	CDD:290200	11/137 (8%)
		C2H2 Zn finger	665..685	CDD:275368	10/19 (53%)
		zf-H2C2_2	677..701	CDD:290200	13/23 (57%)
		C2H2 Zn finger	693..713	CDD:275368	10/20 (50%)
		zf-H2C2_2	706..730	CDD:290200	9/24 (38%)
		C2H2 Zn finger	721..741	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754		7/24 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000