DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	942	Identity:	192/942 - (20%)
Similarity:	270/942 - (28%)	Gaps:	378/942 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 QEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSH-QPND-----PQLAWKAHSRHYN 192
            ||..|:.|.|..:.:.|...|......:.|....|||..... .|.:     ||.|.........
Human    21 QEEDRQEEEVTTMILEDDSWVQEAVLQEDGPESEPFPQSAGKGGPQEEVTRGPQGALGRLRELCR 85

  Fly   193 GWLEP----TEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVNAGSEMVVDGRPKSP 253
            .||.|    .|.:.|.|.|            .:|:::.                    :.||:|.
Human    86 RWLRPEVHTKEQMLTMLPK------------EIQAWLQ--------------------EHRPESS 118

  Fly   254 VQ-------LNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPSDDRS----------D 301
            .:       |.:...:.|........:...|...||..|:            |:          .
Human   119 EEAAALVEDLTQTLQDSGSQRVHQPFSVLTVCKVSSRSAR------------RALELHLNYFEIQ 171

  Fly   302 RDNGSLYSGDEF-SKDKKNSSLIREGD-IDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHH- 363
            .:||...:.|.| ::.:|..|.:.||: ...:|.|:.|:...        .:..|..|..|..|
Human   172 SENGENCNQDMFENESRKIFSEMPEGESAQHSDGESDFERDA--------GIQRLQGHSPGEDHG 228

  Fly   364 --FKQDE-----------------FPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCD 409
              ..||.                 :.|.||...|..:..||.||. :|...:.|.|:.|.|.|.|
Human   229 EVVSQDREVGQLIGLQGTYLGEKPYECPQCGKTFSRKSHLITHER-THTGEKYYKCDECGKSFSD 292

  Fly   410 PSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHK 474
            .||..|| :..|.|.:.:.|.:|||:|..|:.|..||.||:..|||.|..|.|::::..||..|:
Human   293 GSNFSRH-QTTHTGEKPYKCRDCGKSFSRSANLITHQRIHTGEKPFQCAECGKSFSRSPNLIAHQ 356

  Fly   475 RMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAA 539
            |.| |......|.:|.:||...:||..|:..  .||..||.
Human   357 RTH-TGEKPYSCPECGKSFGNRSSLNTHQGI--HTGEKPYE------------------------ 394

  Fly   540 TATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPT 604
                 |    :|..||
Human   395 -----C----KECGES------------------------------------------------- 401

  Fly   605 NIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKE 669
                 ||.|                                     ..:...:.:...|:..|..
Human   402 -----FSYN-------------------------------------SNLIRHQRIHTGEKPYKCT 424

  Fly   670 PLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMST 734
            ...|.|      |:||..|..:...|
Human   425 DCGQRF------SQSSALITHRRTHT--------------------------------------- 444

  Fly   735 PPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSA 799
                     |:.|...|.|.|..:.|       .||..||   |.|..|    :|.|......|.
Human   445 ---------GEKPYQCSECGKSFSRS-------SNLATHR---RTHMVE----KPYKCGVCGKSF 486

  Fly   800 ESSTS----QKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSA 860
            ..|:|    |..|.|..|....|.               ||..|.|..           ...|..
Human   487 SQSSSLIAHQGMHTGEKPYECLTC---------------GESFSWSSN-----------LLKHQR 525

  Fly   861 LASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGS 925
            :.:|..                     |:.|...|:                       .||..|
Human   526 IHTGEK---------------------PYKCSECGK-----------------------CFSQRS 546

  Fly   926 --VVGLKT---KDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNI 985
              ||..:|   :..|.|..|||.|.|.:.|..|.|.|.|::||.|..|.:.||.:|.|..|.| |
Human   547 QLVVHQRTHTGEKPYKCLMCGKSFSRGSILVMHQRAHLGDKPYRCPECGKGFSWNSVLIIHQR-I 610

  Fly   986 HNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |..|:|::|..|.:.|...:|...|.:.|..|
Human   611 HTGEKPYKCPECGKGFSNSSNFITHQRTHMKE 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	25/128 (20%)
		C2H2 Zn finger	341..363	CDD:275368	3/21 (14%)
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	9/86 (10%)
		COG5048	935..>1028	CDD:227381	33/83 (40%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	9/23 (39%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	5/19 (26%)
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011	19/118 (16%)
		COG5048	251..631	CDD:227381	138/647 (21%)
		C2H2 Zn finger	255..275	CDD:275368	8/20 (40%)
		C2H2 Zn finger	283..303	CDD:275368	9/20 (45%)
		C2H2 Zn finger	311..331	CDD:275368	9/19 (47%)
		C2H2 Zn finger	339..359	CDD:275368	7/19 (37%)
		C2H2 Zn finger	367..387	CDD:275368	7/21 (33%)
		C2H2 Zn finger	395..415	CDD:275368	7/114 (6%)
		C2H2 Zn finger	423..443	CDD:275368	6/25 (24%)
		C2H2 Zn finger	451..471	CDD:275368	9/29 (31%)
		C2H2 Zn finger	479..499	CDD:275368	4/19 (21%)
		C2H2 Zn finger	507..527	CDD:275368	6/45 (13%)
		C2H2 Zn finger	535..555	CDD:275368	7/42 (17%)
		C2H2 Zn finger	563..583	CDD:275368	9/19 (47%)
		C2H2 Zn finger	591..611	CDD:275368	8/20 (40%)
		C2H2 Zn finger	619..639	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000