DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and mecom

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_017206701.1	Gene:	mecom / 497407	ZFINID:	ZDB-GENE-050208-123	Length:	1257	Species:	Danio rerio

Alignment Length:	1236	Identity:	367/1236 - (29%)
Similarity:	507/1236 - (41%)	Gaps:	364/1236 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 PVEGSPPRRDHLDIQDQELLHHPNHFH----QQNQRQQPPPPTLPLSVESSSAAAASVDGMDAFF 123
            ||..||              ::|: ||    |.|...:..||...|
Zfish    58 PVTPSP--------------YYPS-FHTSMYQPNDAVEAVPPDFEL------------------- 88

  Fly   124 KDRAQAEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHS 188
            ::.|.....|..|.|||                   |:.|.|.||......|...:....|:...
Zfish    89 RESAAFRGNLGVWTRRR-------------------LEVGERLGPDEGTSRHSLENATQGWEGEQ 134

  Fly   189 RHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINA----GYLWYETNRYVNAGSEMVV--- 246
            ...:|   ...|..:||:.::      |..:..|..:.|    ..::|...|.|..|.|:::
Zfish   135 AGLDG---SVCDSRSWLRHVQ------ISPSTHQHNLTACQIHEQIFYRVVREVQPGEELLLFMK 190

  Fly   247 --------------DGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAASSSGAKSGGGGSSAPS- 296
                          :.|.......:.:|.:|.::|.....|..   ...|||.|....|  .||
Zfish   191 AEEFSYETMAPDIHEERQYRCEDCDLNFESGSELLDHQKHACG---TPPSSGFKLSKQG--LPSA 250

  Fly   297 DDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGA 361
            ||.:|.:...|::        ...:|.|...            .|:.|::|:||...||.|.:.
Zfish   251 DDDTDLEPLHLHT--------LPPNLPRSPQ------------ECKECEQVFPDAQSLDTHSLS- 294

  Fly   362 HHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARC 426
             |..:.|:.|.||...|..:..||:|: :||::.:.|.||||||||.||||||||||:.|||||.
Zfish   295 -HSDEREYKCDQCPKAFNWKSNLIRHQ-MSHDSGKHYECENCSKVFTDPSNLQRHIRSQHVGARA 357

  Fly   427 HPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQ 491
            |.||:|||||.||||||||:|||||||||.||||.|:|||||||||||||||.||.||||..|.|
Zfish   358 HACPDCGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQ 422

  Fly   492 SFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESS 556
            .|||.:||.||::||:.                         :.|.||
Zfish   423 MFSTTSSLNKHRRFCEG-------------------------KNHFAA----------------- 445

  Fly   557 SSAAAAAVAAMSTPPNPFL-------MFRTAPSF--------------FPGFP---PYGFPPFLP 597
             :|.......|:.|.||.|       |...:|..              ||..|   |:.||...|
Zfish   446 -AAGGLFAQGMALPGNPGLDKSALAGMSHGSPGLADYFGTNRHHSGLTFPAAPPAFPFSFPGLFP 509

  Fly   598 QNPLH-PTNIPMFFSKNPMDLGCGGPE--------ITSPVSAFDQKL------PFGFLKGENSES 647
            ....| |..||   |.:|::   |.|.        ::||:|...:.|      .|.. :.||.|.
Zfish   510 SGLYHRPPLIP---STSPIN---GPPSTELRKSPLLSSPISGSHELLKSLRKDSFNG-ESENMER 567

  Fly   648 QAYDKVTEKELVFKAEEKLKKEPL--VQAFEGEEDESRSSLDIKGKLEDTR-------------- 696
            |....:::.....|..::.:...|  |....|.|.||.|..::..::|..|
Zfish   568 QREGSISKPRHGGKMSDQSESSDLDDVSTPSGSELESTSGSELDSEVESDRERVRVRENGKGPKR 632

  Fly   697 -----ND---------SKSEEQDDMKQEPERVSTP---DQQQAEDDRKSIDIMSTPPPADTPSGG 744
                 ||         |.|...:::|..|.....|   |:|.|.....:..|.:....|:...|.
Zfish   633 KSSGFNDAQSPTLVSSSSSSNTNNVKDFPAPGLLPPSLDEQTAVSGAVNDSIKAIASIAEKYFGS 697

  Fly   745 DGPLDLSICRKRSAG----------SFFTA--------PAEDNLMLHRFMPRLHEFEAERGQPLK 791
            .|   |:..:.:..|          |||.|        |..:.|     .|..|:.|.| ..|::
Zfish   698 TG---LAGLQDKKVGALPYPSMFPLSFFPAFSPSVYPFPEREQL-----RPPGHKGEPE-SPPVE 753

  Fly   792 MRKSHS-SAES----STSQKSHK-GSSPTPT-PTASPGLTPSPSPP--TSAGGELSSTSEGGAVP 847
            .:|... :|||    :|.:|..: .::..|. |.||...:.:...|  .|.|......||.|. .
Zfish   754 SKKPQGRNAESPFDLTTKRKEERLAATCAPVKPEASHVQSTNQDQPLDLSLGRRNRGKSERGE-E 817

  Fly   848 TMAAAAFAADHSALASGPTLPQTHPTFH-----PLLLEEIYR---------------------SG 886
            ...::||:.:...    |..|:|.|:..     |..::.|||                     .|
Zfish   818 IKKSSAFSEERVE----PEPPKTDPSLQHARPMPFFMDPIYRVEKRKMNDPFEVLKDKYMRPAPG 878

  Fly   887 FPFLCQ---PGGRRGIEAL------LAGAASA-----------------AAPKRPLPPVKFSAGS 925
            |.|..|   |..|..:.|:      |...:|.                 .||...||......|
Zfish   879 FLFHPQFRMPDQRTWMSAIENMAEKLESFSSLKPDGGDIMRSVPSMFDFRAPPTTLPETLLRKG- 942

  Fly   926 VVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKER 990
                  |:||:|::|||: |||||||||||||||||||.||||||:||||||||||:|||||||:
Zfish   943 ------KERYTCRYCGKIXPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRHIRNIHNKEK 1001

  Fly   991 PFRCELCDRSFGQQTNLDRHVKKHESEGN---NFRDSP-----SSSGIAEREE--YFDDIRKFMN 1045
            ||:|.||||.||||||||||:||||: ||   ....||     |||.|.|.:|  ||::||.|::
Zfish  1002 PFKCHLCDRCFGQQTNLDRHLKKHEN-GNLAGTAMSSPRSELDSSSAILEDKEDSYFNEIRNFIS 1065

  Fly  1046 RV--------YTPNSLAGNEGDTEEYPNSDDQSVNLEKDSGNFNNNSSNISNNNSSSGNNNNSSK 1102
            ..        .:...|.|:..|.:: ..|...|.:|:::.|      ..:......:.:|:.:.|
Zfish  1066 NTARNATSPSQSEEGLNGSHFDGDK-ALSGQGSRDLDEEEG------EELGAEEEEAEHNDGARK 1123

  Fly  1103 A 1103
            |
Zfish  1124 A 1124

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	25/142 (18%)
		C2H2 Zn finger	341..363	CDD:275368	8/21 (38%)
		C2H2 Zn finger	371..392	CDD:275368	7/20 (35%)
		SFP1	<391..479	CDD:227516	70/87 (80%)
		C2H2 Zn finger	400..421	CDD:275368	18/20 (90%)
		SUF4-like	403..>445	CDD:411020	34/41 (83%)
		C2H2 Zn finger	403..421	CDD:411020	15/17 (88%)
		C2H2 Zn finger	429..449	CDD:275368	16/19 (84%)
		C2H2 Zn finger	457..477	CDD:275368	17/19 (89%)
		C2H2 Zn finger	486..504	CDD:275368	10/17 (59%)
		PTZ00121	<641..>728	CDD:173412	24/119 (20%)
		COG5048	935..>1028	CDD:227381	73/100 (73%)
		zf-C2H2	935..957	CDD:395048	16/21 (76%)
		C2H2 Zn finger	937..957	CDD:275368	15/19 (79%)
		zf-H2C2_2	949..973	CDD:404364	21/23 (91%)
		C2H2 Zn finger	965..986	CDD:275368	18/20 (90%)
		C2H2 Zn finger	994..1014	CDD:275368	16/19 (84%)
mecom	XP_017206701.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	50	1.000	Domainoid score	I11742
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3196
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm26104
orthoMCL	1	0.900	-	-		OOG6_105951
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2993
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.960