DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF724

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001342333.1	Gene:	ZNF724 / 440519	HGNCID:	32460	Length:	619	Species:	Homo sapiens

Alignment Length:	751	Identity:	157/751 - (20%)
Similarity:	238/751 - (31%)	Gaps:	319/751 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   307 LYSGDEFSKD-KKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDH------------- 357
            ::..|::.|| .|.|:..|.     ..::|.|  :|:.|.|.:..|..|..|
Human   144 IFQCDKYVKDFHKFSNSNRH-----KTEKNPF--KCKECGKSFCVLSHLTQHKRIHTTVNSYKLE 201

  Fly   358 ----------LIGAH---HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCD 409
                      .:..|   |..|..:.|::|.:.|.....|..|:.| |...:.|..|.|.|.|..
Human   202 ECGKAFNVSSTLSQHKRIHTGQKHYKCEECGIAFNKSSHLNTHKII-HTGEKSYKREECGKAFNI 265

  Fly   410 PSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHK 474
            .|:|..| :..|.|...:.|.||||.|..||.|.:|:.||:..||:.||.|.:|:.|.|||.:||
Human   266 SSHLTTH-KIIHTGENAYKCKECGKAFNQSSTLTRHKIIHAGEKPYICEHCGRAFNQSSNLTKHK 329

  Fly   475 RMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNR---------HHQHPHQHP 530
            |:| |.....||::|.::|:..::||:||:.  .||..||:.:...:         .|:..|...
Human   330 RIH-TGDKPYKCEECGKAFNVSSTLTQHKRI--HTGEKPYKCEECGKAFNVSSTLTQHKRIHTGE 391

  Fly   531 LPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPF 595
            .|::......|.:|       ||.                      ..|......|..||....
Human   392 KPYKCEECGKAFNT-------SSH----------------------LTTHKRIHTGEKPYKCEE- 426

  Fly   596 LPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVF 660
                                   ||        .||:|                :.::|..:::.
Human   427 -----------------------CG--------KAFNQ----------------FSQLTTHKIIH 444

  Fly   661 KAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDD 725
            ..|:..|.:...:||
Human   445 TGEKPYKCKECGKAF-------------------------------------------------- 459

  Fly   726 RKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPL 790
                                         |||:          ||..||.   :|..|    :|.
Human   460 -----------------------------KRSS----------NLTEHRI---IHTGE----KPY 478

  Fly   791 KMRKS----HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAA 851
            |..:.    :.|:..:|.:|.|.|..|............|
Human   479 KCEECGKAFNLSSHLTTHKKIHTGEKPYKCKECGKAFNQS------------------------- 518

  Fly   852 AAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPL 916
                   |.||       .|...|                                   |.::|
Human   519 -------STLA-------RHKIIH-----------------------------------AGEKP- 533

  Fly   917 PPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRH 981
                              |.|:.|||.|.:.:|||:|...||||:||.|:.|.:||:.||.|.:|
Human   534 ------------------YKCEECGKAFYQYSNLTQHKIIHTGEKPYKCEECGKAFNWSSTLTKH 580

  Fly   982 VRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
             :.||..|:|::|:.|.::|.|.:||..|.|.|..|
Human   581 -KVIHTGEKPYKCKECGKAFNQCSNLTTHKKIHAVE 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/47 (15%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	37/87 (43%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	11/19 (58%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	5/86 (6%)
		COG5048	935..>1028	CDD:227381	38/83 (46%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	9/19 (47%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF724	NP_001342333.1	KRAB	4..64	CDD:214630
		COG5048	143..526	CDD:227381	116/605 (19%)
		C2H2 Zn finger	172..192	CDD:275368	6/19 (32%)
		C2H2 Zn finger	201..220	CDD:275368	1/18 (6%)
		C2H2 Zn finger	228..248	CDD:275368	6/20 (30%)
		C2H2 Zn finger	257..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	10/19 (53%)
		C2H2 Zn finger	312..332	CDD:275368	11/19 (58%)
		C2H2 Zn finger	340..360	CDD:275368	7/21 (33%)
		C2H2 Zn finger	368..388	CDD:275368	1/19 (5%)
		C2H2 Zn finger	396..416	CDD:275368	5/48 (10%)
		C2H2 Zn finger	424..444	CDD:275368	6/67 (9%)
		C2H2 Zn finger	452..472	CDD:275368	9/111 (8%)
		C2H2 Zn finger	480..500	CDD:275368	3/19 (16%)
		C2H2 Zn finger	508..528	CDD:275368	5/58 (9%)
		SFP1	<530..610	CDD:227516	36/99 (36%)
		C2H2 Zn finger	536..556	CDD:275368	9/19 (47%)
		zf-H2C2_2	548..572	CDD:316026	13/23 (57%)
		C2H2 Zn finger	564..584	CDD:275368	8/20 (40%)
		C2H2 Zn finger	592..612	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000