DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and hb

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_731267.1	Gene:	hb / 41032	FlyBaseID:	FBgn0001180	Length:	758	Species:	Drosophila melanogaster

Alignment Length:	1030	Identity:	195/1030 - (18%)
Similarity:	306/1030 - (29%)	Gaps:	388/1030 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 FAAR------HHL--------PQQEPVEGSPPRRDHLDIQDQELLHHPNHFHQQNQRQQPPPPTL 102
            |||.      |||        |:|.|:    |..:||    ::.|.     .||.|.||.|..||
  Fly    23 FAANIKQEPGHHLDGNSVASSPRQSPI----PSTNHL----EQFLK-----QQQQQLQQQPMDTL 74

  Fly   103 PLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREPVCELDIRDSGGVYAKTPLQRGTRYG 167
                                                     |           |.||
  Fly    75 -----------------------------------------C-----------AMTP-------- 79

  Fly   168 PFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWY 232
                  |...||     :...:||:.                ::|...:.:...|.:..|....:
  Fly    80 ------SPSQND-----QNSLQHYDA----------------NLQQQLLQQQQYQQHFQAAQQQH 117

  Fly   233 ETNRYVNAG-SEMVVDGRPKSPVQLNEDFMNGGKV--------LAAAAAAAAAVVAASS------ 282
            ..:.::..| :.:...|.| :|:|    ...||.:        .:|:..|..||...||
  Fly   118 HHHHHLMGGFNPLTPPGLP-NPMQ----HFYGGNLRPSPQPTPTSASTIAPVAVATGSSEKLQAL 177

  Fly   283 ----------SGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGF 337
                      |.||      |:.|:...::::      |:.|...::...:.|.:   .||.|
  Fly   178 TPPMDVTPPKSPAK------SSQSNIEPEKEH------DQMSNSSEDMKYMAESE---DDDTN-- 225

  Fly   338 DIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCEN 402
             ||..:.:                                             ||..::.|.|:.
  Fly   226 -IRMPIYN---------------------------------------------SHGKMKNYKCKT 244

  Fly   403 CSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQF 467
            |..|.....:...|.|.:....:...||:|.........|:.|...|.:.|||.|:.||......
  Fly   245 CGVVAITKVDFWAHTRTHMKPDKILQCPKCPFVTEFKHHLEYHIRKHKNQKPFQCDKCSYTCVNK 309

  Fly   468 SNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHP----HQ 528
            |.|..|::.|::. .|.:|..|:  ::|        |:|.|.      ..|:.::...|    .:
  Fly   310 SMLNSHRKSHSSV-YQYRCADCD--YAT--------KYCHSF------KLHLRKYGHKPGMVLDE 357

  Fly   529 HPLPHQPHLAATATSTCPAP------PRESSESSSSAAAAAVAAM------STPPNPFLMFRTAP 581
            ...|: |.|......|...|      |..|..|.|.:..:.|||:      |.|..|....:.:.
  Fly   358 DGTPN-PSLVIDVYGTRRGPKSKNGGPIASGGSGSGSRKSNVAAVAPQQQQSQPAQPVATSQLSA 421

  Fly   582 SFFPGFP-------PYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSP-------VSAFD 632
            : ..|||       |....|.||. |..|........:.        |.:.||       .|...
  Fly   422 A-LQGFPLVQGNSAPPAASPVLPL-PASPAKSVASVEQT--------PSLPSPANLLPPLASLLQ 476

  Fly   633 QKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRN 697
            |.....|....|...|......:..::.:...:::::...|                   ...::
  Fly   477 QNRNMAFFPYWNLNLQMLAAQQQAAVLAQLSPRMREQLQQQ-------------------NQQQS 522

  Fly   698 DSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFF 762
            |::.|||||                |.:|||:               |..:||      |.|
  Fly   523 DNEEEEQDD----------------EYERKSV---------------DSAMDL------SQG--- 547

  Fly   763 TAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSS----------------AESSTSQKSHKGS 811
            |...||........|.....:.|......|..|::|                :|:.||.:..|..
  Fly   548 TPVKEDEQQQQPQQPLAMNLKVEEEATPLMSSSNASRRKGRVLKLDTLLQLRSEAMTSPEQLKVP 612

  Fly   812 SPTPTPTAS---PGLTPSPSPPTSAGGELSSTSEGGAVP----TMAAAAFAADHSALASGPTLPQ 869
            | ||.||||   .|..|.|....|.......:.|...||    :.::.|.::.:|:.||.
  Fly   613 S-TPMPTASSPIAGRKPMPEEHCSGTSSADESMETAHVPQANTSASSTASSSGNSSNASS----- 671

  Fly   870 THPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASA-AAPKRPLPPVKFSAGSVVGLKTKD 933
                                  ...|.....:...|..|| |||....|.   :||::
  Fly   672 ----------------------NSNGNSSSNSSSNGTTSAVAAPPSGTPA---AAGAI------- 704

  Fly   934 RYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHV-RNIHN 987
             |.||:|...|..:...|.|:..|:.:..:.|..|.........|..|: ||.|:
  Fly   705 -YECKYCDIFFKDAVLYTIHMGYHSCDDVFKCNMCGEKCDGPVGLFVHMARNAHS 758

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	15/122 (12%)
		C2H2 Zn finger	341..363	CDD:275368	0/21 (0%)
		C2H2 Zn finger	371..392	CDD:275368	0/20 (0%)
		SFP1	<391..479	CDD:227516	24/87 (28%)
		C2H2 Zn finger	400..421	CDD:275368	5/20 (25%)
		SUF4-like	403..>445	CDD:411020	8/41 (20%)
		C2H2 Zn finger	403..421	CDD:411020	4/17 (24%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		C2H2 Zn finger	457..477	CDD:275368	6/19 (32%)
		C2H2 Zn finger	486..504	CDD:275368	3/17 (18%)
		PTZ00121	<641..>728	CDD:173412	11/86 (13%)
		COG5048	935..>1028	CDD:227381	15/54 (28%)
		zf-C2H2	935..957	CDD:395048	7/21 (33%)
		C2H2 Zn finger	937..957	CDD:275368	6/19 (32%)
		zf-H2C2_2	949..973	CDD:404364	5/23 (22%)
		C2H2 Zn finger	965..986	CDD:275368	6/21 (29%)
		C2H2 Zn finger	994..1014	CDD:275368
hb	NP_731267.1	C2H2 Zn finger	242..262	CDD:275368	5/19 (26%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		zf-H2C2_2	283..308	CDD:290200	9/24 (38%)
		C2H2 Zn finger	299..319	CDD:275368	6/19 (32%)
		C2H2 Zn finger	327..345	CDD:275368	7/33 (21%)
		C2H2 Zn finger	707..727	CDD:275371	6/19 (32%)
		C2H2 Zn finger	735..757	CDD:275371	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100