DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF888

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	XP_016882287.1	Gene:	ZNF888 / 388559	HGNCID:	38695	Length:	830	Species:	Homo sapiens

Alignment Length:	722	Identity:	161/722 - (22%)
Similarity:	246/722 - (34%)	Gaps:	233/722 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   319 NSSLIREGDI-----DFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRF 378
            :|.|.::.|:     .|..:|:|....|.         .|...|.|  .|..:.::.|..|...|
Human   310 SSLLTQKQDVHRKEKSFQFNESGKSFNCS---------SLFKKHQI--IHLGEKQYKCDVCGKDF 363

  Fly   379 CHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLK 443
            ..:..|..|.. .|...:.|.|..|.|||...:.|.||.|. |.|.:.:.|.||||||...|.|.
Human   364 NQKRYLAHHRR-CHTGEKPYMCNKCGKVFNKKAYLARHYRR-HTGEKPYKCNECGKTFSDKSALL 426

  Fly   444 QHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDS 508
            .|:.||:..||:.|..|.|.:.|.|||.||.|:| |.....:|.:|::.||..:.|.:|::.  .
Human   427 VHKTIHTGEKPYKCNECGKVFNQQSNLARHHRVH-TGEKPYQCKECDKVFSRKSYLERHRRI--H 488

  Fly   509 TGPGPYRNQHVN---RHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTP 570
            ||..||:.:..:   ||..|..||.:.|        |...|....|..::....:|
Human   489 TGEKPYKCKVCDKAFRHDSHLAQHIVIH--------TREKPYKCNECGKTFGENSA--------- 536

  Fly   571 PNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKL 635
               .|:.:|                     :|....|...::      ||        ..|:|:.
Human   537 ---LLVHKT---------------------IHTGEKPYKCNE------CG--------KVFNQQS 563

  Fly   636 PFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSK 700
            ........::..:.| |..|.:.||..:..|::...:..  ||:       ..|.|:.|     |
Human   564 NLARHHRLHTGEKPY-KCKECDKVFSRKSHLERHRRIHT--GEK-------PYKCKVCD-----K 613

  Fly   701 SEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAP 765
            :..:|....:...:.|                           |:.|...:.|.|       |..
Human   614 AFRRDSHLAQHTVIHT---------------------------GEKPYKCNECGK-------TFV 644

  Fly   766 AEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKS-------HKGSSPTPTPTASPGL 823
            ...:|::|:.   :|..|       |..|.:...:|...:.|       |.|..|
Human   645 QNSSLVMHKV---IHTGE-------KRYKCNECGKSFNHKSSLAYHHRLHTGEKP---------- 689

  Fly   824 TPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFP 888
                          ...:|.|.|  ....:..|.|..|.:|..                     |
Human   690 --------------YKCNECGKV--FRTQSQLACHHRLHTGEK---------------------P 717

  Fly   889 FLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKT-----------KDRYSCKFCGK 942
            :.|:                             ....|..:|:           :..|.|:.|.|
Human   718 YKCE-----------------------------ECDKVFNIKSHLEIHRRVHTGEKPYKCRVCDK 753

  Fly   943 VFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNL 1007
            .|.|.:.|.:|.|.||||:||.||.||:||...|:|.:|.| ||..|:||:|..|.::|..|:.|
Human   754 AFGRDSYLAQHQRVHTGEKPYKCKVCDKAFKCYSHLAQHTR-IHTGEKPFKCSECGKAFRAQSTL 817

  Fly  1008 DRHVKKH 1014
            ..|...|
Human   818 IHHQAIH 824

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	4/21 (19%)
		C2H2 Zn finger	371..392	CDD:275368	5/20 (25%)
		SFP1	<391..479	CDD:227516	38/87 (44%)
		C2H2 Zn finger	400..421	CDD:275368	9/20 (45%)
		SUF4-like	403..>445	CDD:411020	19/41 (46%)
		C2H2 Zn finger	403..421	CDD:411020	8/17 (47%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	14/86 (16%)
		COG5048	935..>1028	CDD:227381	37/80 (46%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	14/23 (61%)
		C2H2 Zn finger	965..986	CDD:275368	10/20 (50%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF888	XP_016882287.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000