DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment ham and ZNF808

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_001034975.2 Gene:ZNF808 / 388558 HGNCID:33230 Length:903 Species:Homo sapiens


Alignment Length:807 Identity:180/807 - (22%)
Similarity:276/807 - (34%) Gaps:248/807 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   311 DEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCA 375
            :|..|....|||:|:..|....|:   ..:|:||.|::.....|..|  ...|..:..:.||:|.
Human   234 NESGKAFNCSSLLRKHQIPHLGDK---QYKCDVCGKLFNHKQYLACH--RRCHTGEKPYKCKECG 293

  Fly   376 LRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSS 440
            ..|.::..|..|..: |..::.|.|..|.|||...|.|..| :|.|.|.:.:.|.||||.|...|
Human   294 KSFSYKSSLTCHHRL-HTGVKPYKCNECGKVFRQNSALVIH-KAIHTGEKPYKCNECGKAFNQQS 356

  Fly   441 GLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKF 505
            .|.:||.:|:.|||:.|::|.||:...|.|..|.|:|:. ....||::|.::|:..:||.:|...
Human   357 HLSRHQRLHTGVKPYKCKICEKAFACHSYLANHTRIHSG-EKTYKCNECGKAFNHQSSLARHHIL 420

  Fly   506 CDSTGPGPYRNQHVNR---------HHQHPHQHPLPHQPHLAATA------------------TS 543
              .||..||:.:..::         .|:..|....|::..:..||                  |.
Human   421 --HTGEKPYKCEECDKVFSQKSTLERHKRIHTGEKPYKCKVCDTAFTCNSQLARHRRIHTGEKTY 483

  Fly   544 TCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPM 608
            .|....:..|..||                                     .|....||....|.
Human   484 KCNECRKTFSRRSS-------------------------------------LLCHRRLHSGEKPY 511

  Fly   609 FFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAY-----DKVTEKELVFKAEEKL-- 666
            ..::      ||        :.|..:....:.:..::..::|     :||..:..|.....::  
Human   512 KCNQ------CG--------NTFRHRASLVYHRRLHTLEKSYKCTVCNKVFMRNSVLAVHTRIHT 562

  Fly   667 KKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDI 731
            .|:|......|:....:|.|....:|.......|.|..|.:.         .|:.|.:..|.|..
Human   563 AKKPYKCNECGKAFNQQSHLSRHRRLHTGEKPYKCEACDKVF---------GQKSALESHKRIHT 618

  Fly   732 MSTPPPADTPSGGDGPLDLSIC-----------------------RKRSAGSFFTAPAEDNLMLH 773
                        |:.|....:|                       :....|..|:  .:.:|:.|
Human   619 ------------GEKPYRCQVCDTAFTWNSQLARHTRIHTGEKTYKCNECGKTFS--YKSSLVWH 669

  Fly   774 RFMPRLHEFEAE------------RGQPLKMRKSHSSAE-------SST-SQKS--------HKG 810
            |   |||..|..            |....|..:.||..:       |.| |.:|        |.|
Human   670 R---RLHGGEKSYKCKVCDKAFVCRSYVAKHTRIHSGMKPYKCNECSKTFSNRSSLVCHRRIHSG 731

  Fly   811 SSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFH 875
            ..|......|                          .|.:..|....|..|.||..         
Human   732 EKPYKCSECS--------------------------KTFSQKATLLCHRRLHSGEK--------- 761

  Fly   876 PLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKF 939
                        |:.|...|.     .....:|....:|              |.|.:: |.|..
Human   762 ------------PYKCNDCGN-----TFRHWSSLVYHRR--------------LHTGEKSYKCTV 795

  Fly   940 CGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQ 1004
            |.|.|.|::.|.||:|.||.|:||.|..|.:||:..|:|.||.| ||..|:|::||.||:.|.::
Human   796 CDKAFVRNSYLARHIRIHTAEKPYKCNECGKAFNEQSHLSRHHR-IHTGEKPYKCEACDKVFSRK 859

  Fly  1005 TNLDRHVKKHESE--------GNNFRD 1023
            ::|.||...|..|        |..|.|
Human   860 SHLKRHRIIHTGEKPYKCNECGKAFSD 886

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 6/21 (29%)
C2H2 Zn finger 371..392 CDD:275368 6/20 (30%)
SFP1 <391..479 CDD:227516 36/87 (41%)
C2H2 Zn finger 400..421 CDD:275368 9/20 (45%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 8/17 (47%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 8/19 (42%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 15/93 (16%)
COG5048 935..>1028 CDD:227381 41/97 (42%)
zf-C2H2 935..957 CDD:395048 10/21 (48%)
C2H2 Zn finger 937..957 CDD:275368 9/19 (47%)
zf-H2C2_2 949..973 CDD:404364 12/23 (52%)
C2H2 Zn finger 965..986 CDD:275368 9/20 (45%)
C2H2 Zn finger 994..1014 CDD:275368 8/19 (42%)
ZNF808NP_001034975.2 KRAB 24..64 CDD:307490
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 121..154
COG5048 206..585 CDD:227381 94/411 (23%)
C2H2 Zn finger 233..253 CDD:275368 7/18 (39%)
C2H2 Zn finger 261..281 CDD:275368 6/21 (29%)
C2H2 Zn finger 289..309 CDD:275368 6/20 (30%)
C2H2 Zn finger 317..337 CDD:275368 9/20 (45%)
C2H2 Zn finger 345..365 CDD:275368 10/19 (53%)
C2H2 Zn finger 373..393 CDD:275368 8/19 (42%)
COG5048 397..839 CDD:227381 105/586 (18%)
C2H2 Zn finger 401..421 CDD:275368 6/21 (29%)
C2H2 Zn finger 429..449 CDD:275368 1/19 (5%)
C2H2 Zn finger 457..477 CDD:275368 2/19 (11%)
C2H2 Zn finger 485..505 CDD:275368 5/56 (9%)
C2H2 Zn finger 513..533 CDD:275368 3/33 (9%)
C2H2 Zn finger 541..561 CDD:275368 3/19 (16%)
C2H2 Zn finger 569..589 CDD:275368 3/19 (16%)
C2H2 Zn finger 597..617 CDD:275368 5/28 (18%)
C2H2 Zn finger 625..645 CDD:275368 1/19 (5%)
C2H2 Zn finger 653..673 CDD:275368 6/24 (25%)
C2H2 Zn finger 681..701 CDD:275368 2/19 (11%)
C2H2 Zn finger 709..729 CDD:275368 4/19 (21%)
C2H2 Zn finger 737..757 CDD:275368 4/45 (9%)
C2H2 Zn finger 765..785 CDD:275368 4/38 (11%)
C2H2 Zn finger 793..813 CDD:275368 9/19 (47%)
SFP1 <816..893 CDD:227516 29/72 (40%)
C2H2 Zn finger 821..841 CDD:275368 9/20 (45%)
C2H2 Zn finger 849..869 CDD:275368 8/19 (42%)
C2H2 Zn finger 877..897 CDD:275368 3/10 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

Return to query results.
Submit another query.