DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF728

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001254645.1	Gene:	ZNF728 / 388523	HGNCID:	32463	Length:	622	Species:	Homo sapiens

Alignment Length:	735	Identity:	148/735 - (20%)
Similarity:	221/735 - (30%)	Gaps:	339/735 - (46%)

- Green bases have known domain annotations that are detailed below.

  Fly   302 RDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLI---GAHH 363
            |:|.  |..:|..|....||.:....| .|.::   ..:||.|.|.:....:|..|.:   |..|
Human   197 RENS--YKSEEHGKAFNWSSALTYKRI-HTGEK---PCKCEECGKAFSKFSILTKHKVIHTGEKH 255

  Fly   364 FKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHP 428
            :|     |::|...|.....||:|:. ||...:.|.||.|.|.|...|.|..| :..|.|.:.:.
Human   256 YK-----CEECGKAFTRSSSLIEHKR-SHAGEKPYKCEECGKAFSKASTLTAH-KTIHAGEKPYK 313

  Fly   429 CPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSF 493
            |.||||.|..||.|.:|:.||:..||..||.|.||:..||.|.:||.:| |.....||::|.::|
Human   314 CEECGKAFNRSSNLMEHKRIHTGEKPCKCEECGKAFGNFSTLTKHKVIH-TGEKPYKCEECGKAF 377

  Fly   494 STLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSS 558
            |..:|||:||:.  ..|..||:.:.
Human   378 SWPSSLTEHKRI--HAGDKPYKCEE---------------------------------------- 400

  Fly   559 AAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPE 623
                                                                        ||
Human   401 ------------------------------------------------------------CG--- 402

  Fly   624 ITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDI 688
                                              ..||....|.|..::..
Human   403 ----------------------------------KTFKWSSTLTKHKIIHT-------------- 419

  Fly   689 KGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSIC 753
                                                                   |:.|.....|
Human   420 -------------------------------------------------------GEKPYKCEEC 429

  Fly   754 RKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPT 818
                 |..||  ...:|..|:.   :|                      |.:|.:|
Human   430 -----GKAFT--TFSSLTKHKV---IH----------------------TGEKHYK--------- 453

  Fly   819 ASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIY 883
                                 ..|.|.|.:.:::  ...|.|:.:|               |::|
Human   454 ---------------------CEECGKVFSWSSS--LTTHKAIHAG---------------EKLY 480

  Fly   884 RSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPRS 947
            :      |:..|:     ....:::....||              :.|.:: |.|:.|||.|.:.
Human   481 K------CEECGK-----AFKWSSNLMEHKR--------------IHTGEKPYKCEECGKAFSKV 520

  Fly   948 ANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVK 1012
            ||||:|...||||:.|.|:.|.:||..||.|..|.| ||..|:|::||.|.::|...:.|::|.|
Human   521 ANLTKHKVIHTGEKQYKCEECGKAFIWSSRLSEHKR-IHTGEKPYKCEECGKAFSWVSVLNKHKK 584

  Fly  1013 KH--------ESEGNNFRDS 1024
            .|        |..|.:|..|
Human   585 IHAGKKFYKCEECGKDFNQS 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	7/24 (29%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	38/87 (44%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	8/17 (47%)
		PTZ00121	<641..>728	CDD:173412	4/86 (5%)
		COG5048	935..>1028	CDD:227381	41/98 (42%)
		zf-C2H2	935..957	CDD:395048	11/21 (52%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	7/19 (37%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	186..583	CDD:227381	141/712 (20%)
		C2H2 Zn finger	230..250	CDD:275368	6/19 (32%)
		C2H2 Zn finger	258..278	CDD:275368	6/20 (30%)
		C2H2 Zn finger	286..306	CDD:275368	8/20 (40%)
		C2H2 Zn finger	314..334	CDD:275368	10/19 (53%)
		zf-H2C2_2	326..349	CDD:290200	10/22 (45%)
		C2H2 Zn finger	342..362	CDD:275368	10/19 (53%)
		zf-H2C2_2	355..378	CDD:290200	8/23 (35%)
		C2H2 Zn finger	370..390	CDD:275368	9/21 (43%)
		zf-H2C2_2	382..406	CDD:290200	10/162 (6%)
		C2H2 Zn finger	398..418	CDD:275368	6/156 (4%)
		zf-H2C2_2	411..435	CDD:290200	8/99 (8%)
		C2H2 Zn finger	426..446	CDD:275368	6/29 (21%)
		C2H2 Zn finger	454..474	CDD:275368	5/21 (24%)
		C2H2 Zn finger	482..502	CDD:275368	4/38 (11%)
		zf-H2C2_2	494..518	CDD:290200	8/37 (22%)
		C2H2 Zn finger	510..530	CDD:275368	10/19 (53%)
		zf-H2C2_2	522..545	CDD:290200	11/22 (50%)
		C2H2 Zn finger	538..558	CDD:275368	9/20 (45%)
		zf-H2C2_2	551..574	CDD:290200	10/23 (43%)
		C2H2 Zn finger	566..586	CDD:275368	7/19 (37%)
		C2H2 Zn finger	594..614	CDD:275368	4/11 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000