DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF568

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	727	Identity:	161/727 - (22%)
Similarity:	234/727 - (32%)	Gaps:	288/727 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   339 IRCEVCDKVYP-------------DLDLLD---DHLI-------GAHHFKQDE------------ 368
            |.|:...|::|             |.|.||   :|.:       |....||..
Human   153 IECKKVAKIFPLSSDIVTSRQSFYDCDSLDKGLEHNLDLLRYEKGCVREKQSNEFGKPFYHCASY 217

  Fly   369 ----FPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPC 429
                |.|.||...|.|:..||:||.| |...:.|.|:.|.|.|....||..| :..|.|.:.:.|
Human   218 VVTPFKCNQCGQDFSHKFDLIRHERI-HAGEKPYECKECGKAFSRKENLITH-QKIHTGEKPYKC 280

  Fly   430 PECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFS 494
            .||||.|...|.|.:|..||:..||:||:.|.||::|.|||..|:|:| |.....:|.:|.:|||
Human   281 NECGKAFIQMSNLIRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERIH-TGEKPYECKECGKSFS 344

  Fly   495 TLTSLTKHKKFCDSTGPGPYRNQHVNRH---------HQHPHQHPLPHQPHLAATATSTCPAPPR 550
            ...:|.:|:|.  .||..||......|.         |...|....|::.:....|.|.|..
Human   345 QKQNLIEHEKI--HTGEKPYACNECGRAFSRMSSVTLHMRSHTGEKPYKCNKCGKAFSQCSV--- 404

  Fly   551 ESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPM 615
                                                        |:.....|....|...|:
Human   405 --------------------------------------------FIIHMRSHTGEKPYVCSE--- 422

  Fly   616 DLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEED 680
               ||        .||.|.
Human   423 ---CG--------KAFSQS---------------------------------------------- 430

  Fly   681 ESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGD 745
               |||.:     ..||.: :|:..:.|:..:..|..:.            :.|.....|   |:
Human   431 ---SSLTV-----HMRNHT-AEKPYECKECGKAFSRKEN------------LITHQKIHT---GE 471

  Fly   746 GPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKG 810
            .|.:.|.|.|    :|...   .||:.|                               |:.|.|
Human   472 KPYECSECGK----AFIQM---SNLIRH-------------------------------QRIHTG 498

  Fly   811 SSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFH 875
            ..|...                               |:...||:            .:::.|.|
Human   499 EKPYAC-------------------------------TVCGKAFS------------QKSNLTEH 520

  Fly   876 PLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFC 940
                |:|:....|:.|...|:           :.:..:..|...|...|       :..:.|..|
Human   521 ----EKIHTGEKPYHCNQCGK-----------AFSQRQNLLEHEKIHTG-------EKPFKCNEC 563

  Fly   941 GKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQT 1005
            ||.|.|.::||.|:|:||||:||.|..|.:|||..|.|..|:|: |..|:||.|..|.::|.|:.
Human   564 GKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRS-HTGEKPFECNECGKAFSQRA 627

  Fly  1006 NLDRHVKKHESE 1017
            :|..|.:.|..|
Human   628 SLSIHKRGHTGE 639

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	9/44 (20%)
		C2H2 Zn finger	371..392	CDD:275368	10/20 (50%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	7/20 (35%)
		SUF4-like	403..>445	CDD:411020	16/41 (39%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	8/86 (9%)
		COG5048	935..>1028	CDD:227381	37/83 (45%)
		zf-C2H2	935..957	CDD:395048	10/21 (48%)
		C2H2 Zn finger	937..957	CDD:275368	10/19 (53%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	6/19 (32%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	10/20 (50%)
		zf-H2C2_2	236..261	CDD:290200	11/25 (44%)
		COG5048	248..634	CDD:227381	135/624 (22%)
		C2H2 Zn finger	252..272	CDD:275368	7/20 (35%)
		zf-H2C2_2	264..289	CDD:290200	11/25 (44%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		zf-H2C2_2	292..317	CDD:290200	11/24 (46%)
		C2H2 Zn finger	308..328	CDD:275368	10/19 (53%)
		zf-H2C2_2	320..345	CDD:290200	10/25 (40%)
		C2H2 Zn finger	336..356	CDD:275368	8/21 (38%)
		zf-H2C2_2	348..373	CDD:290200	8/26 (31%)
		C2H2 Zn finger	364..384	CDD:275368	2/19 (11%)
		zf-H2C2_2	380..401	CDD:290200	4/20 (20%)
		C2H2 Zn finger	392..412	CDD:275368	4/66 (6%)
		zf-H2C2_2	408..429	CDD:290200	7/34 (21%)
		C2H2 Zn finger	420..440	CDD:275368	10/87 (11%)
		zf-H2C2_2	432..457	CDD:290200	6/30 (20%)
		C2H2 Zn finger	448..468	CDD:275368	3/31 (10%)
		zf-H2C2_2	460..485	CDD:290200	8/43 (19%)
		C2H2 Zn finger	476..496	CDD:275368	8/57 (14%)
		zf-H2C2_2	488..513	CDD:290200	10/98 (10%)
		C2H2 Zn finger	504..524	CDD:275368	6/66 (9%)
		zf-H2C2_2	516..541	CDD:290200	7/39 (18%)
		C2H2 Zn finger	532..552	CDD:275368	4/30 (13%)
		zf-H2C2_2	544..569	CDD:290200	8/31 (26%)
		C2H2 Zn finger	560..580	CDD:275368	10/19 (53%)
		zf-H2C2_2	572..597	CDD:290200	14/24 (58%)
		C2H2 Zn finger	588..608	CDD:275368	9/20 (45%)
		zf-H2C2_2	601..625	CDD:290200	10/24 (42%)
		C2H2 Zn finger	616..636	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000