DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF429

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:XP_016882237.1 Gene:ZNF429 / 353088 HGNCID:20817 Length:689 Species:Homo sapiens


Alignment Length:691 Identity:151/691 - (21%)
Similarity:227/691 - (32%) Gaps:277/691 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   334 ENGFDIRCEVCDKVYPDLDLLDDH---LIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNI 395
            ||.:  ||:.....:.....|.:|   .:|..|::     |::|...|.|...|..|:.| |...
Human   213 ENTY--RCKEFGNAFNQSSALTNHKRIYVGEKHYR-----CEECGKAFNHYSTLTNHKRI-HTGE 269

  Fly   396 RKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVC 460
            :.|.|:.|.|.|...|.|..|.| .|.|.:.:.|.||||||..||...:|:.||:..||:.|:.|
Human   270 KPYKCKECGKAFSRYSTLTTHKR-IHSGEKPYKCDECGKTFSISSTFTKHKIIHTEEKPYKCKEC 333

  Fly   461 SKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQH 525
            .||:.:.|.|..|||:| |.....||::|.::|:..::|||||..  .||..||:.:.       
Human   334 GKAFNRSSTLTSHKRIH-TGEKPYKCEECGKAFNWSSTLTKHKVI--HTGEKPYKCEE------- 388

  Fly   526 PHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPY 590
                                                                             
Human   389 ----------------------------------------------------------------- 388

  Fly   591 GFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTE 655
                                        ||        .||:|.                .::|.
Human   389 ----------------------------CG--------KAFNQS----------------SRLTR 401

  Fly   656 KELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQ 720
            .:.:...||..|.|...:.|                     ..|.:..||      :::.|    
Human   402 HKKIHTGEEPYKFEKCGRVF---------------------TCSSTLTQD------KKIHT---- 435

  Fly   721 QAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPRLHEFEAE 785
                                   |:.|.:...|     |..||  ....|..|:   |:|..|  
Human   436 -----------------------GEKPYNCEEC-----GKVFT--YSSTLTRHK---RIHTEE-- 465

  Fly   786 RGQPLKMRKS----HSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGELSSTSEGGAV 846
              :|.|..:.    :.|:..::.::.|.|..|............|        ..|:|       
Human   466 --KPYKCNECGKAFNRSSHLTSHRRIHTGEKPYKCEECGKAFKQS--------SNLNS------- 513

  Fly   847 PTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAA 911
                       |..:.||..                     |:.|:..|:..|           .
Human   514 -----------HKKIHSGEK---------------------PYKCEECGKAFI-----------L 535

  Fly   912 PKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISS 976
            ..|.....|...|       :..|.|:.|||.|.||:.||:|.:.||||:||.||.||:||:.||
Human   536 SSRLTQHKKIHTG-------EKPYKCEECGKAFNRSSRLTQHKKIHTGEKPYKCKQCDKAFTHSS 593

  Fly   977 NLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            ||..| :.||:.|:|::||.|.::|.:.:.|.:|.|.|..|
Human   594 NLSSH-KKIHSGEKPYKCEECGKAFNRSSRLTQHKKIHTRE 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 4/24 (17%)
C2H2 Zn finger 371..392 CDD:275368 7/20 (35%)
SFP1 <391..479 CDD:227516 36/87 (41%)
C2H2 Zn finger 400..421 CDD:275368 8/20 (40%)
SUF4-like 403..>445 CDD:411020 18/41 (44%)
C2H2 Zn finger 403..421 CDD:411020 7/17 (41%)
C2H2 Zn finger 429..449 CDD:275368 10/19 (53%)
C2H2 Zn finger 457..477 CDD:275368 9/19 (47%)
C2H2 Zn finger 486..504 CDD:275368 7/17 (41%)
PTZ00121 <641..>728 CDD:173412 10/86 (12%)
COG5048 935..>1028 CDD:227381 41/83 (49%)
zf-C2H2 935..957 CDD:395048 11/21 (52%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 14/23 (61%)
C2H2 Zn finger 965..986 CDD:275368 11/20 (55%)
C2H2 Zn finger 994..1014 CDD:275368 7/19 (37%)
ZNF429XP_016882237.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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