DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and ZNF850

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	775	Identity:	183/775 - (23%)
Similarity:	284/775 - (36%)	Gaps:	206/775 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   310 GDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQC 374
            |..|:   ..|:|||...|.  ..|..:|  |:.|.|.:.....|..|  ...|..:..:.||:|
Human   343 GKSFA---SGSALIRHQRIH--TGEKPYD--CKECGKSFTFHSALIRH--QRIHTGEKPYDCKEC 398

  Fly   375 ALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTS 439
            ...|..|..||.|:|| |...:.|.|:.|.|.|...|.|.:|.| .|.|.:.:.|.||||:|.:.
Human   399 GKSFTFRSGLIGHQAI-HTGEKPYDCKECGKSFTAGSTLIQHQR-IHTGEKPYDCKECGKSFASG 461

  Fly   440 SGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKK 504
            |.|.|||.||:..||:.|:.|.|::|..|...||:|:| |......|.:|.:||::.::|.:|::
Human   462 SALLQHQRIHTGEKPYCCKECGKSFTFRSTRNRHQRIH-TGEKPYNCKECGKSFASGSALLQHQR 525

  Fly   505 FCDSTGPGPYRNQHVNRH---------HQHPHQHPLPHQPHLAATATSTCPAPPRESSES-SSSA 559
            .  .||..||..:...:.         ||..|....|:.          |    :|..:| :|.:
Human   526 I--HTGEKPYHCKECGKSFTFRSGLIGHQAVHTGEKPYD----------C----KECGKSFTSRS 574

  Fly   560 AAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDL-GCGGPE 623
            |......:.|...|:.......||..|      ...|....:|.       .:.|.|. .||
Human   575 ALIQHQRIHTGEKPYHCKECGKSFTVG------STLLQHQQIHT-------GEKPYDCKECG--- 623

  Fly   624 ITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDI 688
                 .||..:|                ::|:.:.:...|:..:.:...:||          :.:
Human   624 -----KAFRLRL----------------RLTQHQQIHTGEKPYQCQECGKAF----------VSV 657

  Fly   689 KGKLEDTR-----------NDSKSEEQDDMKQEPERVSTPD---------------------QQQ 721
            .|..:..|           :..|:..|.....:..|:.|.:                     ||.
Human   658 SGLTQHHRIHTGEKPYECPDCGKAFRQRTYLNQHRRIHTGEKPYECKECGKSFTFCSGLIQHQQN 722

  Fly   722 AEDDR--------KSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLMLHRFMPR 778
            ..|::        ||....||.........|:.|.|...|     |..||  :...|:.|:   :
Human   723 HTDEKPYDGKECGKSFTSHSTLIQHQQIHTGEKPYDCKEC-----GKSFT--SHSTLIQHQ---Q 777

  Fly   779 LHEFEAERGQPLKMRKSHSSAESSTS-------QKSHKGSSPTPTPTASPGLTPSPS----PPTS 832
            :|..|       |:.......:|.||       |..|.|..|..........|...:    .|..
Human   778 IHTGE-------KLYDCKECGKSFTSHSTLIQHQPLHTGEKPYHCKECGKSFTLRSALIQHRPVH 835

  Fly   833 AGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRR 897
            .|.:..|..|.|  .:..:.:...:|..:.:|..                     |:.|:..|:
Human   836 TGEKRYSCKECG--KSFTSRSTLIEHQRIHTGEK---------------------PYHCKECGK- 876

  Fly   898 GIEALLAGAASAAAPKRPLPPVKFSAGSVV----GLKTKDR-YSCKFCGKVFPRSANLTRHLRTH 957
                                  .|:..|.:    .:.|.:: |.||.|||.|.|.:.||:|.|.|
Human   877 ----------------------SFAFRSAIIQHRRIHTGEKPYDCKECGKAFRRRSKLTQHQRIH 919

  Fly   958 TGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |||:||.|..|.:||...|.|.:| .:||..|:|:.|:.|.:||.|:|:|..|.:.|..:
Human   920 TGEKPYRCHECGKAFVRFSGLTKH-HSIHTGEKPYECKTCGKSFRQRTHLTLHQRIHTGD 978

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	10/20 (50%)
		SFP1	<391..479	CDD:227516	36/87 (41%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	11/19 (58%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	13/126 (10%)
		COG5048	935..>1028	CDD:227381	38/83 (46%)
		zf-C2H2	935..957	CDD:395048	12/21 (57%)
		C2H2 Zn finger	937..957	CDD:275368	11/19 (58%)
		zf-H2C2_2	949..973	CDD:404364	13/23 (57%)
		C2H2 Zn finger	965..986	CDD:275368	7/20 (35%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381	99/390 (25%)
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200	2/7 (29%)
		C2H2 Zn finger	339..359	CDD:275368	6/18 (33%)
		zf-H2C2_2	351..375	CDD:290200	9/27 (33%)
		C2H2 Zn finger	367..387	CDD:275368	5/21 (24%)
		zf-H2C2_2	379..403	CDD:290200	6/25 (24%)
		C2H2 Zn finger	395..415	CDD:275368	10/20 (50%)
		C2H2 Zn finger	423..443	CDD:275368	8/20 (40%)
		zf-H2C2_2	436..460	CDD:290200	11/24 (46%)
		C2H2 Zn finger	451..471	CDD:275368	11/19 (58%)
		zf-H2C2_2	463..487	CDD:290200	11/23 (48%)
		C2H2 Zn finger	479..499	CDD:275368	8/19 (42%)
		zf-H2C2_2	493..516	CDD:290200	9/23 (39%)
		C2H2 Zn finger	507..527	CDD:275368	6/21 (29%)
		zf-H2C2_2	519..543	CDD:290200	6/25 (24%)
		COG5048	531..947	CDD:227381	100/540 (19%)
		C2H2 Zn finger	535..555	CDD:275368	2/19 (11%)
		C2H2 Zn finger	563..583	CDD:275368	5/23 (22%)
		zf-H2C2_2	575..599	CDD:290200	4/23 (17%)
		C2H2 Zn finger	591..611	CDD:275368	4/25 (16%)
		C2H2 Zn finger	619..639	CDD:275368	6/43 (14%)
		zf-H2C2_2	632..656	CDD:290200	4/33 (12%)
		C2H2 Zn finger	647..667	CDD:275368	4/29 (14%)
		zf-H2C2_2	660..684	CDD:290200	2/23 (9%)
		C2H2 Zn finger	675..695	CDD:275368	3/19 (16%)
		zf-H2C2_2	687..711	CDD:290200	2/23 (9%)
		C2H2 Zn finger	703..723	CDD:275368	2/19 (11%)
		C2H2 Zn finger	732..751	CDD:275368	4/18 (22%)
		C2H2 Zn finger	759..779	CDD:275368	6/29 (21%)
		C2H2 Zn finger	787..807	CDD:275368	4/19 (21%)
		C2H2 Zn finger	815..835	CDD:275368	2/19 (11%)
		C2H2 Zn finger	843..863	CDD:275368	3/21 (14%)
		zf-H2C2_2	856..879	CDD:290200	5/66 (8%)
		C2H2 Zn finger	871..891	CDD:275368	4/42 (10%)
		C2H2 Zn finger	899..919	CDD:275368	11/19 (58%)
		zf-H2C2_2	912..936	CDD:290200	14/23 (61%)
		C2H2 Zn finger	927..947	CDD:275368	7/20 (35%)
		C2H2 Zn finger	955..975	CDD:275368	8/19 (42%)
		zf-H2C2_2	967..992	CDD:290200	3/12 (25%)
		C2H2 Zn finger	983..1003	CDD:275368
		zf-H2C2_2	995..1020	CDD:290200
		C2H2 Zn finger	1011..1031	CDD:275368
		zf-H2C2_2	1024..1046	CDD:290200
		C2H2 Zn finger	1039..1059	CDD:275368
		zf-H2C2_2	1052..1076	CDD:290200
		C2H2 Zn finger	1067..1087	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000