DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ham and ZNF680

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_848653.2	Gene:	ZNF680 / 340252	HGNCID:	26897	Length:	530	Species:	Homo sapiens

Alignment Length:	662	Identity:	130/662 - (19%)
Similarity:	190/662 - (28%)	Gaps:	325/662 - (49%)

- Green bases have known domain annotations that are detailed below.

  Fly   369 FPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECG 433
            |.||:|...||....|.:|..| |.....|.||.|.||....|.|.:| :..|:|.:.:.|.|||
Human   182 FKCKECGKSFCMLSHLTQHIRI-HTRENSYKCEECGKVLNWFSELIKH-KGIHMGEKPYKCEECG 244

  Fly   434 KTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTS 498
            |.|..||.|.:|:.||...|||.||.|.||::.||.|.:||.:| |.....|||:|:::|:...:
Human   245 KAFNQSSTLIKHKKIHIEEKPFKCEECGKAFSLFSILSKHKIIH-TGDKPYKCDECHKAFNWFAT 308

  Fly   499 LTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRESSESSSSAAAAA 563
            ||.||:.  .||..|::.:.
Human   309 LTNHKRI--HTGEKPFKCEE--------------------------------------------- 326

  Fly   564 VAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPV 628
                                                                   ||
Human   327 -------------------------------------------------------CG-------- 328

  Fly   629 SAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLE 693
            ..|:|                :..:|:.:.:...|:..|.|...:||
Human   329 KDFNQ----------------FSNLTKHKKIHTGEKPYKCEECGKAF------------------ 359

  Fly   694 DTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSA 758
                                     .|.|
Human   360 -------------------------NQFA------------------------------------ 363

  Fly   759 GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGL 823
                      ||..|:   ::|                      |.:||:|..........|..|
Human   364 ----------NLTRHK---KIH----------------------TGEKSYKCEECGKAFIQSSNL 393

  Fly   824 TPSPSPPTSAGGELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFP 888
            |                                :|..:.:|..                     |
Human   394 T--------------------------------EHMRIHTGEK---------------------P 405

  Fly   889 FLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YSCKFCGKVFPRSANLTR 952
            :.|:..|:     ...|.:|....||              :.|::. |.|:.|||.|...:.||.
Human   406 YKCEECGK-----AFNGCSSLTRHKR--------------IHTRENTYKCEECGKGFTLFSTLTN 451

  Fly   953 HLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |...||||:.|.|..|...|:..:.|..|.| ||.:|:|::||.|.::|.:.::|.||.|.|..|
Human   452 HKVIHTGEKSYKCDECGNVFNWPATLANHKR-IHAREKPYKCEECGKAFNRSSHLTRHKKIHTGE 515

  Fly  1018 --------GNNF 1021
                    .|||
Human   516 KLYKPEKCDNNF 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978
		C2H2 Zn finger	341..363	CDD:275368
		C2H2 Zn finger	371..392	CDD:275368	8/20 (40%)
		SFP1	<391..479	CDD:227516	38/87 (44%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	6/17 (35%)
		C2H2 Zn finger	429..449	CDD:275368	10/19 (53%)
		C2H2 Zn finger	457..477	CDD:275368	10/19 (53%)
		C2H2 Zn finger	486..504	CDD:275368	7/17 (41%)
		PTZ00121	<641..>728	CDD:173412	8/86 (9%)
		COG5048	935..>1028	CDD:227381	37/95 (39%)
		zf-C2H2	935..957	CDD:395048	9/21 (43%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	10/23 (43%)
		C2H2 Zn finger	965..986	CDD:275368	6/20 (30%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
ZNF680	NP_848653.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	152..513	CDD:227381	125/646 (19%)
		zf-C2H2	182..204	CDD:278523	9/22 (41%)
		C2H2 Zn finger	184..204	CDD:275368	8/20 (40%)
		C2H2 Zn finger	212..232	CDD:275368	8/20 (40%)
		zf-H2C2_2	224..249	CDD:290200	10/25 (40%)
		C2H2 Zn finger	240..260	CDD:275368	10/19 (53%)
		zf-H2C2_2	253..276	CDD:290200	12/22 (55%)
		C2H2 Zn finger	268..288	CDD:275368	10/19 (53%)
		zf-H2C2_2	281..304	CDD:290200	9/23 (39%)
		C2H2 Zn finger	296..316	CDD:275368	8/21 (38%)
		zf-H2C2_2	309..333	CDD:290200	10/133 (8%)
		C2H2 Zn finger	324..344	CDD:275368	5/143 (3%)
		zf-H2C2_2	336..361	CDD:290200	6/67 (9%)
		C2H2 Zn finger	352..372	CDD:275368	8/111 (7%)
		zf-H2C2_2	364..389	CDD:290200	8/49 (16%)
		C2H2 Zn finger	380..400	CDD:275368	4/51 (8%)
		zf-H2C2_2	392..416	CDD:290200	7/81 (9%)
		C2H2 Zn finger	408..428	CDD:275368	6/38 (16%)
		C2H2 Zn finger	436..456	CDD:275368	8/19 (42%)
		C2H2 Zn finger	464..484	CDD:275368	6/20 (30%)
		zf-H2C2_2	477..501	CDD:290200	11/24 (46%)
		zf-C2H2	490..512	CDD:278523	8/21 (38%)
		C2H2 Zn finger	492..512	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000