DRSC/TRiP Functional Genomics Resources

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Protein Alignment ham and ZNF546

DIOPT Version :9

Sequence 1:NP_724130.4 Gene:ham / 35135 FlyBaseID:FBgn0045852 Length:1108 Species:Drosophila melanogaster
Sequence 2:NP_848639.2 Gene:ZNF546 / 339327 HGNCID:28671 Length:836 Species:Homo sapiens


Alignment Length:731 Identity:173/731 - (23%)
Similarity:267/731 - (36%) Gaps:187/731 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   363 HFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCH 427
            |.::..:.||:|...|..:..||:|..| |...|.|.|..|.|.||...:|:.| ...|.|.|.:
Human   211 HAREKSYECKECRKAFRQQSYLIQHLRI-HTGERPYKCMECGKAFCRVGDLRVH-HTIHAGERPY 273

  Fly   428 PCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQS 492
            .|.||||.|.....|.:||.|||.|||:.|:.|.||:::..:|..|:.:||..| ..:|.:|.::
Human   274 ECKECGKAFRLHYHLTEHQRIHSGVKPYECKECGKAFSRVRDLRVHQTIHAGER-PYECKECGKA 337

  Fly   493 FSTLTSLTKHKKFCDSTGPGPY------RNQHVNRH---HQHPHQHPLPHQPHLAATA------- 541
            |.....||:|::.  .||..||      :...|.||   ||..|....|::.:....|       
Human   338 FRLHYQLTEHQRI--HTGERPYECKVCGKTFRVQRHISQHQKIHTGVKPYKCNECGKAFSHGSYL 400

  Fly   542 -------TSTCPAPPRESSES-SSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQ 598
                   |...|...:|..:| |..|..|....:.|...|:.......:            |..|
Human   401 VQHQKIHTGEKPYECKECGKSFSFHAELARHRRIHTGEKPYECRECGKA------------FRLQ 453

  Fly   599 NPL---HPTNIPMFFSKNPMDL-GCG-----GPEITSPVSAFDQKLPFGFLKGENSESQAYDKVT 654
            ..|   |.|:.    .:.|.:. .||     |.::|..:.....::|:...:...:.|..| .:|
Human   454 TELTRHHRTHT----GEKPYECKECGKAFICGYQLTLHLRTHTGEIPYECKECGKTFSSRY-HLT 513

  Fly   655 EKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQ---------- 709
            :...:...|     :|.:.      :|...:..::|:|.........|:..:.|:          
Human   514 QHYRIHTGE-----KPYIC------NECGKAFRLQGELTRHHRIHTCEKPYECKECGKAFIHSNQ 567

  Fly   710 --EPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNLML 772
              ..:|:.|.:...                              ||::  .|..|:  ...||..
Human   568 FISHQRIHTSESTY------------------------------ICKE--CGKIFS--RRYNLTQ 598

  Fly   773 HRFMPRLHEFEA-----ERGQPLKMRKSHSSAESSTSQKSHKGSSP---TPTPTA---SPGLT-- 824
            |.   ::|..|.     |.|:..:.:     .|.:...:.|.|..|   |....|   |..||  
Human   599 HF---KIHTGEKPYICNECGKAFRFQ-----TELTQHHRIHTGEKPYKCTECGKAFIRSTHLTQH 655

  Fly   825 ------PSPSPPTSAGGELS-----------STSEGGAVPTMAAAAFAADHSALASGPTLPQTHP 872
                  ..|...|..|...|           .|.|...:......||...:..            
Human   656 HRIHTGEKPYECTECGKTFSRHYHLTQHHRGHTGEKPYICNECGNAFICSYRL------------ 708

  Fly   873 TFHPLLLEEIYRSGFPFLCQPGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDR-YS 936
            |.|    :.|:....|:.|:..|:....                   ::.......|.|.:: ||
Human   709 TLH----QRIHTGELPYECKECGKTFSR-------------------RYHLTQHFRLHTGEKPYS 750

  Fly   937 CKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSF 1001
            ||.||..|...|.||||...||||:||.||.|.:|||::|.|.||.| ||..|:|::|:.|.::|
Human   751 CKECGNAFRLQAELTRHHIVHTGEKPYKCKECGKAFSVNSELTRHHR-IHTGEKPYQCKECGKAF 814

  Fly  1002 GQQTNLDRHVKKHESE 1017
            .:...|..|.:.|.||
Human   815 IRSDQLTLHQRNHISE 830

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
hamNP_724130.4 PR-SET_ZFPM 131..253 CDD:380978
C2H2 Zn finger 341..363 CDD:275368 173/731 (24%)
C2H2 Zn finger 371..392 CDD:275368 8/20 (40%)
SFP1 <391..479 CDD:227516 35/87 (40%)
C2H2 Zn finger 400..421 CDD:275368 7/20 (35%)
SUF4-like 403..>445 CDD:411020 16/41 (39%)
C2H2 Zn finger 403..421 CDD:411020 6/17 (35%)
C2H2 Zn finger 429..449 CDD:275368 9/19 (47%)
C2H2 Zn finger 457..477 CDD:275368 6/19 (32%)
C2H2 Zn finger 486..504 CDD:275368 6/17 (35%)
PTZ00121 <641..>728 CDD:173412 12/98 (12%)
COG5048 935..>1028 CDD:227381 41/83 (49%)
zf-C2H2 935..957 CDD:395048 12/21 (57%)
C2H2 Zn finger 937..957 CDD:275368 10/19 (53%)
zf-H2C2_2 949..973 CDD:404364 14/23 (61%)
C2H2 Zn finger 965..986 CDD:275368 11/20 (55%)
C2H2 Zn finger 994..1014 CDD:275368 5/19 (26%)
ZNF546NP_848639.2 KRAB 60..120 CDD:214630
KRAB 60..99 CDD:279668
COG5048 <215..375 CDD:227381 58/164 (35%)
C2H2 Zn finger 219..239 CDD:275368 8/20 (40%)
zf-H2C2_2 231..254 CDD:290200 10/23 (43%)
C2H2 Zn finger 247..267 CDD:275368 7/20 (35%)
C2H2 Zn finger 275..295 CDD:275368 9/19 (47%)
zf-H2C2_2 287..312 CDD:290200 13/24 (54%)
C2H2 Zn finger 303..323 CDD:275368 6/19 (32%)
C2H2 Zn finger 331..351 CDD:275368 6/21 (29%)
zf-H2C2_2 344..366 CDD:290200 7/23 (30%)
C2H2 Zn finger 359..379 CDD:275368 5/19 (26%)
zf-H2C2_2 371..396 CDD:290200 6/24 (25%)
COG5048 383..823 CDD:227381 107/545 (20%)
C2H2 Zn finger 387..407 CDD:275368 1/19 (5%)
zf-H2C2_2 399..423 CDD:290200 4/23 (17%)
C2H2 Zn finger 415..435 CDD:275368 5/19 (26%)
zf-H2C2_2 427..450 CDD:290200 3/34 (9%)
C2H2 Zn finger 443..463 CDD:275368 4/31 (13%)
zf-H2C2_2 455..478 CDD:290200 6/26 (23%)
C2H2 Zn finger 471..491 CDD:275368 4/19 (21%)
C2H2 Zn finger 499..519 CDD:275368 3/20 (15%)
C2H2 Zn finger 527..547 CDD:275368 3/25 (12%)
zf-H2C2_2 539..562 CDD:290200 3/22 (14%)
C2H2 Zn finger 555..575 CDD:275368 2/19 (11%)
C2H2 Zn finger 583..603 CDD:275368 6/26 (23%)
C2H2 Zn finger 611..631 CDD:275368 3/24 (13%)
zf-H2C2_2 623..648 CDD:290200 6/24 (25%)
C2H2 Zn finger 639..659 CDD:275368 5/19 (26%)
zf-H2C2_2 651..676 CDD:290200 5/24 (21%)
C2H2 Zn finger 667..687 CDD:275368 3/19 (16%)
C2H2 Zn finger 695..715 CDD:275368 4/35 (11%)
C2H2 Zn finger 723..743 CDD:275368 2/38 (5%)
C2H2 Zn finger 751..771 CDD:275368 10/19 (53%)
zf-H2C2_2 763..787 CDD:290200 14/23 (61%)
C2H2 Zn finger 779..799 CDD:275368 11/20 (55%)
zf-H2C2_2 791..816 CDD:290200 11/25 (44%)
C2H2 Zn finger 807..827 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.000

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