DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and zld

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001285466.1	Gene:	zld / 32994	FlyBaseID:	FBgn0259789	Length:	1596	Species:	Drosophila melanogaster

Alignment Length:	1316	Identity:	222/1316 - (16%)
Similarity:	365/1316 - (27%)	Gaps:	550/1316 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ARSQGFNPLSEQIEDSFAARHHLPQQEPVEGSPP--------RRDHLDIQDQELLHHPNHFHQQN 92
            |...|.:|..   ...:|:..::.::.|.. .||        ..:.||:..|::::| ....||.
  Fly   300 ANVHGESPYG---SSGYASSPYIKEEMPTP-QPPGVGSATANPGELLDLDSQKMVYH-QQLLQQQ 359

  Fly    93 QRQQPPPPTLPLSVESSSAAAASVDGMDAFFKDRAQAEHILQEWVRR-REPVCELD-----IRDS 151
            |:|......|||....           |.....::..:..|..|.:: ::.|..::     ::..
  Fly   360 QQQHDVVAGLPLGALP-----------DPLHSMQSMQQRALHSWEQQPQQTVASVEGLPPYMQQG 413

  Fly   152 GGVYAKTPLQRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCI 216
            .||.....:.:...|.|                |....|                     |...:
  Fly   414 LGVGLGVGVDKSPYYSP----------------KQSPYH---------------------QSTGV 441

  Fly   217 GEANL--QSYINAGYL---WYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAA 276
            |.|.|  |.|...|.:   :.::..||:...:....|            ..|.::.|:.|.:.|.
  Fly   442 GGATLIKQEYGGHGLIKSEYPDSQHYVDKSFDPTAGG------------AGGAELCASVATSPAE 494

  Fly   277 VVAASSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRC 341
            ..:.::.|....|...:||         |..|.|.|   ...:||::....:
  Fly   495 FPSTTTGGPGQEGAAGAAP---------GGGYRGFE---PPSSSSVLPANSL------------- 534

  Fly   342 EVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKV 406
                            ...|..:|.:|          ..||             :.|:|..|:|.
  Fly   535 ----------------TAKAATWKSNE----------ARRP-------------KTYNCTACNKW 560

  Fly   407 FCDPSNLQRH----------------------IRAYHVGARCH---------------------- 427
            |....:|:||                      |.|:|..||..
  Fly   561 FTSSGHLKRHYNTTLHKNAVKSSGQPDPATLPISAHHHPARDPVTKPSRRGNAAAAAAAAAAAAS 625

  Fly   428 -------------------PCPE-----------CGKTFGTSSGLKQHQHIHSSVKPFACEVCSK 462
                               |.||           .|...|...|....|:   |..|      |.
  Fly   626 ASGQGQQQQPPIPPPPANVPPPEPPRSPPDYGGGGGLGVGAMGGAAMSQY---SASP------SP 681

  Fly   463 AYTQFSNLCRHKRM-----------HATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRN 516
            ...|..:|..|::.           :...:.|::        ||..:..:|..  ::......:.
  Fly   682 TQQQQHHLNHHQQQANGYANGTANGYGYMQQQVQ--------STTNASPQHAS--NNNSNNQQQQ 736

  Fly   517 QHVNRHHQ-------------HPHQHPLPHQPHLAATA-------------TSTCPAP------P 549
            |...:|||             ||:....|..||...|.             |:|.|.|      |
  Fly   737 QQQQQHHQQQMPQHHNSVLNGHPNGLAGPSAPHNNNTTQMPSSQMRGLLNETTTTPPPTTTTRAP 801

  Fly   550 RESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHP-TNIPMFFSKN 613
            :.::.::::..||...|:.:                       ......|..|. |:
  Fly   802 QITTTATTTTTAATTVAIKS-----------------------EQMEDSNHTHTHTH-------- 835

  Fly   614 PMDLGCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGE 678
                       |.|..:..|....   ...:|.|.|.::..|:||   .:::...:.|.|..:..
  Fly   836 -----------THPNHSHSQDRSH---SSSSSSSMATEEAEEQEL---RDQEQADDHLHQHQQAS 883

  Fly   679 EDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQQAEDDRKSIDIMSTPPPADTPSG 743
            :....|:........:|.:.|.:.........|..:...:||..:..|      :||||...|..
  Fly   884 QQYLLSARHYHSSTPNTLSSSNTNPSTPSSNSPHTIYRQEQQGTDFSR------TTPPPQPLPPM 942

  Fly   744 GDGP----------LDLSI------------CRKRSA---GSFFTAPAEDNL------MLHRFMP 777
            |..|          ||:.:            |...|.   .:..|....|.:      ::|.:..
  Fly   943 GMLPPMAMDYNMLALDMPMPMPTLMHSNMLQCSSTSTTPLATTITTSMPDTMQPPQQQLVHHYQA 1007

  Fly   778 RLHEFEAERGQP---------LKMRKSHSSAESSTSQKS--------HKGSSPT---PTPT---- 818
            .||....:.|:.         .:.|:.|...:....|::        |..||||   |.||
  Fly  1008 VLHPLHQQLGEQHQRQEADHHQQQRELHQLDQQQQQQQALILADSLPHSSSSPTSSSPPPTMPMP 1072

  Fly   819 ----ASPGLTP-----------SPSPPT------------------------------------- 831
                .:|.|.|           .|.|||
  Fly  1073 LTTITAPQLLPLQPPPPHITSTMPMPPTMHMPIMPPPPQCYQQLQPLDPTMSYHTIIGSGPEAHT 1137

  Fly   832 -SAGGELS---STSEGGAVPTMAAAAFA-----------------------------ADHSALAS 863
             :|||..|   :||:|..:..|..:.||                             |.|:....
  Fly  1138 GTAGGGYSNQITTSDGQILQLMPTSLFAPYAPLSPYSVAAQRSPQEGDLPPVHTLTTALHAHQQG 1202

  Fly   864 G------PTLPQTHPTFHPLL--------LE---------------EIYRSGFPFLCQ------- 892
            |      |||......:.|.:        ||               |.|:.....|.|
  Fly  1203 GQQEAQTPTLTVLSTPYSPTVSSSRATPALEMDMATLMQHHQDYEMEQYQMQHQQLDQMQQHQQQ 1267

  Fly   893 ----------------------PGGRRGIEALLAGAASAAAPKRPLPPVKFSAGSVVGLKT---K 932
                                  ...|||      |.|:.:..||..   ..|.||.....|   .
  Fly  1268 LDHQQQQQILADQTQTMAQQPLAKKRRG------GNATPSTTKRRR---NSSVGSTSPHSTTLPS 1323

  Fly   933 DRYSCKFCGKVFPRSANLTRHLRT-HTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFRCEL 996
            .|..|..|.|.|.::..||:|.:: |:||.|:.|:.|.:.|........|:.....:::|.:|||
  Fly  1324 GRIKCLECDKEFTKNCYLTQHNKSFHSGEYPFRCQKCGKRFQSEDVYTTHLGRHRTQDKPHKCEL 1388

  Fly   997 CDRSFGQQTNLDRHVK 1012
            |.:.|..:|:|.|||:
  Fly  1389 CPKQFHHKTDLRRHVE 1404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	19/132 (14%)
		C2H2 Zn finger	341..363	CDD:275368	1/21 (5%)
		C2H2 Zn finger	371..392	CDD:275368	2/20 (10%)
		SFP1	<391..479	CDD:227516	26/172 (15%)
		C2H2 Zn finger	400..421	CDD:275368	9/42 (21%)
		SUF4-like	403..>445	CDD:411020	17/115 (15%)
		C2H2 Zn finger	403..421	CDD:411020	8/39 (21%)
		C2H2 Zn finger	429..449	CDD:275368	6/30 (20%)
		C2H2 Zn finger	457..477	CDD:275368	4/30 (13%)
		C2H2 Zn finger	486..504	CDD:275368	3/17 (18%)
		PTZ00121	<641..>728	CDD:173412	15/86 (17%)
		COG5048	935..>1028	CDD:227381	26/79 (33%)
		zf-C2H2	935..957	CDD:395048	7/22 (32%)
		C2H2 Zn finger	937..957	CDD:275368	7/20 (35%)
		zf-H2C2_2	949..973	CDD:404364	9/24 (38%)
		C2H2 Zn finger	965..986	CDD:275368	4/20 (20%)
		C2H2 Zn finger	994..1014	CDD:275368	10/19 (53%)
zld	NP_001285466.1	zf-C2H2_jaz	552..577	CDD:288983	8/24 (33%)
		LIM	1328..1389	CDD:259829	18/60 (30%)
		C2H2 Zn finger	1328..1349	CDD:275368	7/20 (35%)
		C2H2 Zn finger	1357..1377	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1386..1407	CDD:275368	10/19 (53%)
		zf-H2C2_2	1398..1422	CDD:290200	4/7 (57%)
		zf-C2H2	1413..1435	CDD:278523
		C2H2 Zn finger	1415..1435	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010