DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp236

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001361158.1	Gene:	Zfp236 / 329002	MGIID:	1926950	Length:	1847	Species:	Mus musculus

Alignment Length:	1098	Identity:	248/1098 - (22%)
Similarity:	377/1098 - (34%)	Gaps:	323/1098 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 QGFNPLSEQIEDSFAARHHLPQQEPVEGSPPRRDHLDIQDQELLHH---PNHFHQQNQRQQPPPP 100
            |||.     :.|:::.:...|   ||:         .:||...|..   ...|||||..|.|...
Mouse   885 QGFT-----VTDTYSQQTSFP---PVQ---------QLQDSSTLESQALSTSFHQQNLLQVPNSD 932

  Fly   101 TLPLSVESSSAAAASVDGMDAFFKDRAQAEHILQ--EWVRRREPVCELDIRDSG---GVYAKTPL 160
            .  ::|.:.....:|.:.:|.    :.|....|:  |...||...|  |..:.|   ..:.|..:
Mouse   933 A--INVATRLLPESSQEDLDL----QTQGPQFLEDSEDQSRRSYRC--DYCNKGFKKSSHLKQHV 989

  Fly   161 QRGTRYGPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYI 225
            :..|...|:..||..:........|:|.:.:.|              :::.  .|       |..
Mouse   990 RSHTGEKPYKCKLCGRAFVSSGVLKSHEKTHTG--------------VKAF--SC-------SIC 1031

  Fly   226 NAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDF---------MNGGKVLAAAAAAAAAVVAAS 281
            ||.   :.||..:.......:..:|.......|.|         |...:.:::||||||..
Mouse  1032 NAS---FTTNGSLTRHMATHMSMKPYKCPFCEEGFRTAVHCRKHMKRHQAVSSAAAAAAET---- 1089

  Fly   282 SSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCE---- 342
                   .||.:...:             ||.:.|:..|...|...|.||::|.....:.:
Mouse  1090 -------EGGDTCVEE-------------DEENSDRSASRKPRPEVITFTEEETAQLAKIQPQES 1134

  Fly   343 --VCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEA-ISHNNIRKYSCENCS 404
              |.:||........|.:        .|...||..|           || ..|.|    .|..|.
Mouse  1135 ATVSEKVLVQSAAEKDRI--------SEMKDKQAEL-----------EAEPKHAN----CCTYCP 1176

  Fly   405 KVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSN 469
            |.|..||:|.||:| .|.|.:.:.|.||||:|...|.|..|...|:..|.|:|.|||.|::...:
Mouse  1177 KSFKKPSDLVRHVR-IHTGEKPYKCDECGKSFTVKSTLDCHVKTHTGQKLFSCHVCSNAFSTKGS 1240

  Fly   470 LCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKHKKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQ 534
            |..|.|:| |.....||..|...|.|......|.:|                     |....|.:
Mouse  1241 LKVHMRLH-TGAKPFKCPHCELRFRTSGRRKTHMQF---------------------HYKSDPKK 1283

  Fly   535 PHLAATATSTCPAPPRESSESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQN 599
            .....|         |.||||..|  ...:.:.||.||.|:|..   |...|        ...||
Mouse  1284 ARKPVT---------RSSSESLQS--VNLLNSSSTDPNVFIMNN---SVLTG--------QFDQN 1326

  Fly   600 PLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLP---------FGFLKGENSESQAYDKVTE 655
            .|.|..:.....  |..:..|| ::|  ||..|..|.         ...|.|.|.:....|..:.
Mouse  1327 VLQPGLVGQAIL--PASVSAGG-DLT--VSLTDGSLATLEGIQLQLAANLVGPNVQISGIDASSI 1386

  Fly   656 KELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSEEQDDMKQEPERVSTPDQQ 720
            ..:..:.:..:.::.|.|.       |..:..|.|:......:|..:..|         ||....
Mouse  1387 NNITLQIDPSILQQTLQQG-------SLLAQPITGESSTASQNSSLQTSD---------STVPAS 1435

  Fly   721 QAEDDRKSIDIMSTPPPADTPSG------------GDGPLDLS-ICRKRSAGSFFTAPAEDNLML 772
            ........:.:..|...|:...|            ..|..||| :...:...|..|.|.|..|.:
Mouse  1436 VVIQPLSGLSLQPTVTSANLTIGPLSEQDSVLTTSSSGSQDLSQVMTSQGLVSTSTGPHEITLTI 1500

  Fly   773 HRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAGGEL 837
            :                          .||.||...:.:.||.:.::.     ||...|....||
Mouse  1501 N--------------------------NSSLSQVLAQAAGPTASSSSG-----SPQEITLTISEL 1534

  Fly   838 SSTSEGGAVPT---MAAAAFAADHSALASGP---------TLPQTHPTF---------------- 874
            :.:|  |::|:   |:.:|.:|.:..::|..         ||..|....
Mouse  1535 NPSS--GSLPSTAPMSPSAISAQNLVMSSSGVGADASVTLTLADTQGVLSGGLDTVTLNITSQGQ 1597

  Fly   875 -HPLLLEEIYRSGFPFLCQPGGRRGIEALLAG----AASAA----------APKRPLP---PVK- 920
             .|.||.:      |.|...||....:.:|..    ::|||          .|.:..|   |.|
Mouse  1598 QFPALLTD------PSLSGQGGAGSPQVILVSHTPQSSSAAGEEIAYQVTDVPAQLTPHSQPEKE 1656

  Fly   921 ------------FSAGSVV-----GLKTKDR-YSCKFCGKVFPRSANLTRHLRTH------TGEQ 961
                        ||:.:|:     .:..|:| :.|:.|.|.|.|:.:|..|:.||      :.::
Mouse  1657 GLSHQCLDCDRAFSSAAVLMHHSKEVHGKERIHGCRVCRKAFKRATHLKEHMLTHQAGPSLSSQK 1721

  Fly   962 P--YPCKYCDRAFSISSNLQRHVRNIHNKERPFRCELCDRSFGQQTNLDRHVKKHESE 1017
            |  :.|..|::||:..|.|:||.| ||..||||.|.|||::|.|::.|..|:|||..|
Mouse  1722 PRVFKCDSCEKAFAKPSQLERHSR-IHTGERPFHCTLCDKAFNQKSALQVHLKKHTGE 1778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	22/126 (17%)
		C2H2 Zn finger	341..363	CDD:275368	4/27 (15%)
		C2H2 Zn finger	371..392	CDD:275368	5/21 (24%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	10/20 (50%)
		SUF4-like	403..>445	CDD:411020	19/41 (46%)
		C2H2 Zn finger	403..421	CDD:411020	9/17 (53%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	12/86 (14%)
		COG5048	935..>1028	CDD:227381	37/91 (41%)
		zf-C2H2	935..957	CDD:395048	7/21 (33%)
		C2H2 Zn finger	937..957	CDD:275368	7/19 (37%)
		zf-H2C2_2	949..973	CDD:404364	8/31 (26%)
		C2H2 Zn finger	965..986	CDD:275368	9/20 (45%)
		C2H2 Zn finger	994..1014	CDD:275368	9/19 (47%)
Zfp236	NP_001361158.1	COG5048	<30..234	CDD:227381
		C2H2 Zn finger	41..61	CDD:275368
		C2H2 Zn finger	70..90	CDD:275368
		C2H2 Zn finger	97..117	CDD:275368
		C2H2 Zn finger	125..145	CDD:275368
		C2H2 Zn finger	157..177	CDD:275368
		COG5048	197..>550	CDD:227381
		C2H2 Zn finger	201..221	CDD:275368
		C2H2 Zn finger	229..249	CDD:275368
		C2H2 Zn finger	257..278	CDD:275368
		C2H2 Zn finger	289..310	CDD:275368
		C2H2 Zn finger	486..506	CDD:275368
		C2H2 Zn finger	514..534	CDD:275368
		C2H2 Zn finger	542..562	CDD:275368
		zf-H2C2_2	554..579	CDD:372612
		C2H2 Zn finger	570..590	CDD:275368
		COG5048	653..1058	CDD:227381	43/223 (19%)
		C2H2 Zn finger	661..681	CDD:275368
		C2H2 Zn finger	689..709	CDD:275368
		C2H2 Zn finger	717..737	CDD:275368
		C2H2 Zn finger	745..765	CDD:275368
		COG5048	937..1317	CDD:227381	113/495 (23%)
		C2H2 Zn finger	972..992	CDD:275368	4/21 (19%)
		C2H2 Zn finger	1000..1020	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1028..1048	CDD:275368	6/29 (21%)
		C2H2 Zn finger	1172..1192	CDD:275368	10/20 (50%)
		C2H2 Zn finger	1200..1220	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1228..1248	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1256..1276	CDD:275370	6/40 (15%)
		Herpes_BLLF1	<1374..1675	CDD:282904	61/355 (17%)
		C2H2 Zn finger	1662..1683	CDD:275368	3/20 (15%)
		C2H2 Zn finger	1691..1711	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1727..1747	CDD:275368	9/20 (45%)
		zf-H2C2_2	1740..1764	CDD:372612	15/24 (63%)
		C2H2 Zn finger	1755..1775	CDD:275368	9/19 (47%)
		zf-H2C2_2	1767..1792	CDD:372612	6/12 (50%)
		C2H2 Zn finger	1783..1801	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000