DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and erm

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001259891.2	Gene:	erm / 326152	FlyBaseID:	FBgn0031375	Length:	698	Species:	Drosophila melanogaster

Alignment Length:	663	Identity:	155/663 - (23%)
Similarity:	220/663 - (33%)	Gaps:	197/663 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 PLSEQIEDSFAARHHLPQ--QEPVEGSPPRRDHLDIQDQELLHHPNHFHQQNQRQQPPPPTLPLS 105
            |....:.:|.|:..:..|  |:..|.|..|...|.....::: .|:|    ...|.|||...|:|
  Fly    23 PSKSPVMESAASEQNPAQQSQQQDEQSAKRACPLKFSIAKIM-EPDH----RPSQVPPPQPAPVS 82

  Fly   106 VESSSAAAASVDGMDAFFKDRAQAEHILQEWVRRREPVCELDIRDSGGV---------YAKTPLQ 161
            .      |.:.|..|...:..|.:|       |...|:..:.:..|...         |...|..
  Fly    83 F------ATNDDDEDEDPEIDADSE-------RSCSPIEVISLDQSPSTVNYDSAFKKYVPGPCS 134

  Fly   162 RGTR----------------------YGPFPMKLSHQPNDPQLAWKAHSRHYNGWLEPTEDVSTW 204
            ..|.                      ...:|: |.:.||  ||...|.:..|
  Fly   135 GATSSVASPPSTAAVQQFVSSRHQELLSQYPL-LYYAPN--QLMCAAAAAQY------------- 183

  Fly   205 LKKIRSVQDDCIGEANLQSY---INAGYLWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKV 266
             ..:.:.|......|:|.|:   :||.....::.|                        .|.|..
  Fly   184 -AALTAQQQSLASAAHLSSFTASLNASLHHSQSLR------------------------RNLGHP 223

  Fly   267 LAAAAAAAA-------------------AVVAASSSGAKSGGGGSSAPSDDRSDRDNGSL----Y 308
            ||||||.||                   |...|.|||.::.      ....||.:|.|.:    .
  Fly   224 LAAAAAVAAVAQSQAVPNLQHTLEKSPVAQRTAQSSGLQAN------LKRKRSPQDQGEVTPPPA 282

  Fly   309 SGDEFSKDKKNSSLIREGDIDFTDDENGFDIRCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQ 373
            |....:...::.|...:|.|:  |...|                       .|...|...|.|.:
  Fly   283 STATSATGARSRSPSPQGSIE--DSSPG-----------------------SASGGKPKTFSCLE 322

  Fly   374 CALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFGT 438
            |...|.....|.:|..: |...|.:.|:.|.|.|...|.|.|| :..|...:.|.|..|||.|..
  Fly   323 CGKVFNAHYNLTRHMPV-HTGARPFVCKVCGKGFRQASTLCRH-KIIHTSEKPHKCQTCGKAFNR 385

  Fly   439 SSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKH- 502
            ||.|..|..||:..|||.||.|.|.:.|..|...||..|:. ....||:.||::|..:.:||.|
  Fly   386 SSTLNTHSRIHAGYKPFVCEYCGKGFHQKGNYKNHKLTHSG-EKAYKCNICNKAFHQVYNLTFHM 449

  Fly   503 -----KK--FCDSTGPGPYRNQHVNRHHQHPHQ-----HPLPHQPHLAATATSTCPAP------- 548
                 ||  .|.....|..||..:.:|.:..|:     ..|...|........|...|
  Fly   450 HTHNDKKPYTCRVCAKGFCRNFDLKKHMRKLHEIGGDLDDLDMPPTYDRRREYTRREPLASGYGQ 514

  Fly   549 -PRESSESSSSAAAAAVAAMSTPP-------NPFLMFRTAPSFFP--GF-------PPYGFP--- 593
             ..:.:..|||.:.:....::|||       || ...|:|.|.:|  ||       ||:.:|
  Fly   515 ASGQLTPDSSSGSMSPPINVTTPPLSSGETSNP-AWPRSAVSQYPPGGFHHQLGVAPPHDYPSGS 578

  Fly   594 PFL---PQNPLHP 603
            .||   ||.| ||
  Fly   579 AFLQLQPQQP-HP 590

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	21/155 (14%)
		C2H2 Zn finger	341..363	CDD:275368	1/21 (5%)
		C2H2 Zn finger	371..392	CDD:275368	5/20 (25%)
		SFP1	<391..479	CDD:227516	35/87 (40%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		C2H2 Zn finger	486..504	CDD:275368	7/23 (30%)
		PTZ00121	<641..>728	CDD:173412
		COG5048	935..>1028	CDD:227381
		zf-C2H2	935..957	CDD:395048
		C2H2 Zn finger	937..957	CDD:275368
		zf-H2C2_2	949..973	CDD:404364
		C2H2 Zn finger	965..986	CDD:275368
		C2H2 Zn finger	994..1014	CDD:275368
erm	NP_001259891.2	COG5048	<295..461	CDD:227381	58/193 (30%)
		C2H2 Zn finger	320..340	CDD:275368	5/20 (25%)
		zf-H2C2_2	332..357	CDD:290200	8/25 (32%)
		zf-C2H2	346..368	CDD:278523	8/22 (36%)
		C2H2 Zn finger	348..368	CDD:275368	8/20 (40%)
		zf-H2C2_2	363..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	376..396	CDD:275368	9/19 (47%)
		zf-H2C2_2	389..413	CDD:290200	11/23 (48%)
		C2H2 Zn finger	404..424	CDD:275368	8/19 (42%)
		zf-H2C2_2	416..441	CDD:290200	9/25 (36%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		C2H2 Zn finger	460..478	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010