DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and CG32767

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001162674.1	Gene:	CG32767 / 31430	FlyBaseID:	FBgn0052767	Length:	1281	Species:	Drosophila melanogaster

Alignment Length:	1393	Identity:	243/1393 - (17%)
Similarity:	404/1393 - (29%)	Gaps:	587/1393 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 DFDPSASVARHHHH--LHHLDLSARSQGFNPLSEQIEDSFAARHHLPQQEPVEGSPPRRDHLDIQ 77
            |.||......||||  .||....:..|             ..:.||.||               |
  Fly    61 DDDPHQHTHVHHHHHSQHHPHSHSHQQ-------------QQQQHLQQQ---------------Q 97

  Fly    78 DQELLHHPNHFHQQNQRQQPPPPT-------LPLSVESSSAAAASVDGMDAFFKDRA-------- 127
            .|:..|||:|..:.:......|||       :.::..:::.|||:.:...:|..:.:
  Fly    98 QQQQHHHPHHHLKLDNSSNNHPPTAAAAAAAVAVAATTAATAAAATNNSASFSSNSSSSNSNNSN 162

  Fly   128 ----QAEHILQEWVRRREPVC----ELDIRDSG--GVYAKTPLQRGTRYGPFPMKLSHQPNDPQL 182
                |.:.::|:..::::...    .:.|:.:|  .|.|.:.::          :...:..||:|
  Fly   163 HLDNQQQLLIQQQQQQQQHHLLNGRRIIIQATGNSSVLAASDIK----------EEDEEEEDPEL 217

  Fly   183 --------AWKAHSRHYNGWLEPTEDVSTWLKKIRSVQDDCIGEANLQSYINAGYLWYETNRYVN 239
                    ..:|.:...:...|.|..:||.: |:...:||
  Fly   218 NDENLQDIEEEAQAAEADEEPETTAHLSTQV-KLELEEDD------------------------- 256

  Fly   240 AGSEMVVDGRPKSPVQLNED---FMNGGKV---LAAAAAAAAAVVAASSSGAKSGGGGS------ 292
               ||     |....:.:||   .:..|::   ::||...|.|..::::.||.:.||||
  Fly   257 ---EM-----PDEEEEEDEDDDEELQHGQLEYQISAATQTAGAATSSAAGGAATAGGGSQQLVQL 313

  Fly   293 -------------SAPSDDRS-----------DRDNGSLYSGDEF-------------------- 313
                         |.|..:.:           ....|.|.:|..:
  Fly   314 PAGSIVSTTTHRLSVPVTEAALVQLQRRPVYISNAVGGLTAGATYVRMPAAAVISRSPMTVLNVV 378

  Fly   314 ----------------------------------------------------------------- 313

  Fly   379 QQALPATQLILQTQQQQTPAAAAAEQQLALALEQQRQQQEQQAQQQRQQQQQQEQQRQQQQQQQQ 443

  Fly   314 ------------------------------------SKDKKNSSLIREGD--------------- 327
                                                |....|:|.....:
  Fly   444 QQQQQAQQEQQRQQQQQLQQQQQQQQTHPVKHSASGSSSTNNNSTTNSTNSNNNTPAATATVTTS 508

  Fly   328 ------IDFTDDENGFDI---------RCEVCDKVYPDLDLLDDHLIGAHHFKQDEFPCKQC--A 375
                  ::..|.:..|||         :|.:|:.|...|...:.|.:     :...:.|:.|  .
  Fly   509 YQCVECVEKFDSKELFDIHRSGHANNMKCAICNMVLKSLKNYEKHCL-----RCKPYECQICGRV 568

  Fly   376 LRFCHRPLLIKHEAI---SHNNIRKYSCENCSKVFCDPSNLQRHIRAYHVGARCHPCPECGKTFG 437
            :||  ||..|||..:   ..:...||.||.|.|.|......:.|.:.::..... .|..|||.|.
  Fly   569 VRF--RPNFIKHMRVHTGQQSERHKYKCEVCHKEFMSFEYFKVHKKIHNENVNL-TCEICGKVFS 630

  Fly   438 TSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCRMQIKCDKCNQSFSTLTSLTKH 502
            ..:.|:.|..:||.||...|:||.|.:.|..||..|.|.| |.....:|..|.:...|.:||..|
  Fly   631 ALASLRGHSKLHSGVKLHKCDVCGKGFGQRYNLKIHARTH-TGDFPFECKICKKKLHTQSSLQTH 694

  Fly   503 KKFCDSTGPGPYRNQHVNRHHQHPHQHPLPHQPHLAATATSTCPAPPRE--------------SS 553
            .                        |..|..||..||.|.:...|...:              ||
  Fly   695 M------------------------QVHLRDQPGAAAAAATAAGAASSKASNSSNSSNSSNSSSS 735

  Fly   554 ESSSSAAAAAVAAMSTPPNPFLMFRTAPSFFPGFPPYGFPPFLPQNPLHPTNIPMFFSK-NPMDL 617
            .|||:..:|||:|.:|......:               .||...:.|...:|..:..|: :.|:|
  Fly   736 NSSSNGVSAAVSAATTTTTIVKL---------------EPPHEIERPGTSSNQQLQQSQHHQMEL 785

  Fly   618 ----GCGGPEITSPVSAFDQKLPFGFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGE 678
                |..|.|            ..|...|.||.|...:..|.:               :...|..
  Fly   786 DDQSGLSGDE------------EDGSGGGMNSSSHIVNATTNR---------------LTTGEDS 823

  Fly   679 EDESRSSLDIKGKLEDTRNDS-------------KSEEQDDMKQEPERVSTPDQ----------- 719
            .:.|.:||.:......:.:.:             :.::|....|:...||.|.:
  Fly   824 SESSNASLHLNQHSSTSSSPASQHQVSSHQQHVHQQQQQQQQSQQQYLVSAPTRTIVIKNYMQQG 888

  Fly   720 -QQAEDDRKSIDIMSTPPP----------ADTPSGGDGPLDLSICRKRSAGSFFTAPAEDNL--- 770
             ||.:..::.....|.|.|          |.| |.|.|....:.....|:.:..|..|..||
  Fly   889 SQQQQQQQQQQQHTSDPTPVLHAQVIQSGAGT-SNGSGNTSSTNSSSNSSTNIVTTNAGGNLSNG 952

  Fly   771 -MLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTSQKSHKGSSPTPTPTASPGLTPSPSPPTSAG 834
             .|.|..|.:|               ||:..|:.|    .||:.|.....:..::|:.||.:|:.
  Fly   953 SQLIRKTPIIH---------------HSTGSSNGS----GGSALTSVVQQTGVISPAQSPSSSST 998

  Fly   835 GELSSTSEGGAVPTMAAAAFAADHSALASGPTLPQTHPTFHPLLLEEIYRSGFPFLCQPGGRRGI 899
            ...|||                   .|.|..|                               |:
  Fly   999 SCSSST-------------------VLVSKAT-------------------------------GV 1013

  Fly   900 EALLAGAASAAAPKRPLPPVKFSAGSVVGLKTKDRYSCKFCGKVFPRSANLTRHLRTHTGEQPYP 964
            ...:|.:|:||.           .||.:...|::                   |.:....:||..
  Fly  1014 PLSIASSAAAAL-----------GGSTIIRSTRN-------------------HQQQQQQQQPAQ 1048

  Fly   965 CKYCDRAFSISSNLQRHVRNIH----------NKERPFRCELCDRSFGQQTNLDRHVKKHESEGN 1019
            .:...:..:..:|.:.|.|..|          ::::|.:     ::..|||....|...|....:
  Fly  1049 QQQQQQRVTQRNNHRNHHRRRHLADMDDDEDDDEDQPQQ-----QTHTQQTQQHHHHHSHHHNHH 1108

  Fly  1020 NF---------RDSPS--SSGIAEREEYFDDIRKFMNRVYTPNSLAGNEGDTEEYPNSDDQSVNL 1073
            |.         :.|||  ::.|.:.|               ||..:...||     ||:|..:..
  Fly  1109 NHHFDDDDDDEKSSPSLATAAIIKVE---------------PNLYSSGSGD-----NSNDMFIKE 1153

  Fly  1074 E---KDSGNFNNNSS------NISNNNS 1092
            |   :||...::..|      .|||.:|
  Fly  1154 EVMFEDSAALHSPQSPPSSKFRISNFDS 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	19/135 (14%)
		C2H2 Zn finger	341..363	CDD:275368	5/21 (24%)
		C2H2 Zn finger	371..392	CDD:275368	9/25 (36%)
		SFP1	<391..479	CDD:227516	29/87 (33%)
		C2H2 Zn finger	400..421	CDD:275368	6/20 (30%)
		SUF4-like	403..>445	CDD:411020	10/41 (24%)
		C2H2 Zn finger	403..421	CDD:411020	4/17 (24%)
		C2H2 Zn finger	429..449	CDD:275368	7/19 (37%)
		C2H2 Zn finger	457..477	CDD:275368	9/19 (47%)
		C2H2 Zn finger	486..504	CDD:275368	6/17 (35%)
		PTZ00121	<641..>728	CDD:173412	16/111 (14%)
		COG5048	935..>1028	CDD:227381	17/113 (15%)
		zf-C2H2	935..957	CDD:395048	1/21 (5%)
		C2H2 Zn finger	937..957	CDD:275368	1/19 (5%)
		zf-H2C2_2	949..973	CDD:404364	3/23 (13%)
		C2H2 Zn finger	965..986	CDD:275368	3/20 (15%)
		C2H2 Zn finger	994..1014	CDD:275368	4/19 (21%)
CG32767	NP_001162674.1	C2H2 Zn finger	537..557	CDD:275368	5/24 (21%)
		C2H2 Zn finger	562..582	CDD:275368	9/21 (43%)
		C2H2 Zn finger	594..614	CDD:275368	6/19 (32%)
		C2H2 Zn finger	622..642	CDD:275368	7/19 (37%)
		zf-C2H2	648..670	CDD:278523	9/21 (43%)
		C2H2 Zn finger	650..670	CDD:275368	9/19 (47%)
		zf-H2C2_2	662..684	CDD:290200	8/22 (36%)
		C2H2 Zn finger	678..698	CDD:275368	7/43 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24393
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100