DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ham and Zfp316

DIOPT Version :9

Sequence 1:	NP_724130.4	Gene:	ham / 35135	FlyBaseID:	FBgn0045852	Length:	1108	Species:	Drosophila melanogaster
Sequence 2:	NP_001100591.1	Gene:	Zfp316 / 304293	RGDID:	1311647	Length:	1016	Species:	Rattus norvegicus

Alignment Length:	1146	Identity:	248/1146 - (21%)
Similarity:	390/1146 - (34%)	Gaps:	345/1146 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 AARHHLP-----QQEPVE-GSPPRRDHLDIQDQELLHHPNHFHQQNQRQQPPPPTLPLSVESSSA 111
            ||.|..|     |.||.| ||     ..|.:.:|.........:|.:.::.......::.:...|
  Rat     3 AALHTAPDSPDTQLEPAEDGS-----ECDAEPEEEEEEEEEDDEQGREEEEVVVEEEVATQVQEA 62

  Fly   112 AAASVD--------GMDAFFKDRAQAEHILQEWVRRREPVCELDI--RDSGGVYAKTPLQRGTRY 166
            |...|:        |.|.   |....|.:|.|     |....|..  |.|.|..||:|..:|...
  Rat    63 AGVEVEANSADTGGGDDG---DDGDVEEVLAE-----EQTLSLGTQKRLSNGADAKSPALQGKAL 119

  Fly   167 GPFPMKLSHQPNDPQLAWKAH-SRHY-NGWLEPTEDVSTWL-----KKIRSVQDDCIGEANLQSY 224
            ....:..:.|.:||:...:.. ..|: ...|...|||:.:.     :::...|.|...:...::|
  Rat   120 QASRLPPTTQGDDPEEEEEEEDDEHFLTQGLVTFEDVAVYFSLEEWERLDVDQRDLYRDVMQENY 184

  Fly   225 ---INAGY------LWYETNRYVNAGSEMVVDGRPKSPVQLNEDFMNGGKVLAAAAAAAAAVVAA 280
               ::.||      |.:    ::..|.|..|:..| .|.:        |.|:
  Rat   185 GILVSLGYPIPKPDLIF----HLEQGEEPWVEDSP-HPEE--------GDVV------------- 223

  Fly   281 SSSGAKSGGGGSSAPSDDRSDRDNGSLYSGDEFSKDKKN-----SSLIREGDIDFT---DDENGF 337
              :|..:|....:...:|..:.|:....:  |.::::..     |:....||:..|   ||.:..
  Rat   224 --TGVYTGAWFWNDDLEDHEEEDDEDFLA--EMAEEENEPPGLWSAAYGVGDVPGTWGPDDSDSV 284

  Fly   338 ---------------------------------------------------DIRCEVCDKVYPDL 351
                                                               :..|:||.||:|..
  Rat   285 QTPEGWGPNPGSLGILAEEVEAKHFLSGRGPGENFLVPWAFPAVAVPIGCPETTCDVCGKVFPHR 349

  Fly   352 DLLDDHLIGAHHFKQDEFPCKQCALRFCHRPLLIKHEAISHNNIRKYSCENCSKVFCDPSNLQRH 416
            ..|..|  ..:|.....|.|::|...|.:|..|..|:. :|...:.:.|.:|.|.|...|:|..|
  Rat   350 SRLAKH--QRYHAAVKPFGCEECGKGFVYRSHLAIHQR-THTGEKPFPCPDCGKRFVYKSHLVTH 411

  Fly   417 IRAYHVGARCHPCPECGKTFGTSSGLKQHQHIHSSVKPFACEVCSKAYTQFSNLCRHKRMHATCR 481
             |..|.|.|.:.|..||..||..|.|..||..|:..:|:.|..|.::::|.|.|.||:.:|...|
  Rat   412 -RRIHTGERPYRCVFCGAGFGRRSYLVTHQRTHTGERPYPCLHCGRSFSQSSALARHQAVHTADR 475

  Fly   482 MQIKCDKCNQSFSTLTSLTKHKK--FC--DSTGPGPYRNQHVNRHHQHPHQHPL-PHQPHLAATA 541
            ... |..|.|:|.......:|::  .|  .|:|.|..         ..||:..: |::..:|..|
  Rat   476 PHC-CPDCGQAFRLRADFQRHRRGGGCTEPSSGDGAL---------TAPHEVGMAPNEVEMAIAA 530

  Fly   542 TSTCPAPPRE--------SSESSSSAA---------------AAAVAAMSTP-----PNPFLMFR 578
            .:|  |.|.|        :.|..:..|               .||.|..:.|     |.|...||
  Rat   531 VAT--AEPEELESGLAEKNEEPKAGVADGDNEVEVRQDEQVVVAAAAEATVPDSKKDPEPDRRFR 593

  Fly   579 -----TAPSFFPGFPPYGFP-PFLPQNPLHPTNIPMFFSKNPMDLGCGGPEITSPVSAFDQKLPF 637
                 .|....|....:||. |..|::.|||...|:.          |.||.:..:....:.||
  Rat   594 EMGNGLAEGEGPSSHRFGFHFPMHPKSWLHPDGFPLL----------GFPEFSERLQTDGRHLP- 647

  Fly   638 GFLKGENSESQAYDKVTEKELVFKAEEKLKKEPLVQAFEGEEDESRSSLDIKGKLEDTRNDSKSE 702
                                           .||           .:.|.::|.
  Rat   648 -------------------------------GPL-----------GAPLSLQGM----------- 659

  Fly   703 EQDDMKQEPERVSTPDQQQAEDDRKSI-----DIMSTPPPADTPSGGDGPLDLSICRK----RSA 758
               .:..:|.|.:.|. .:|:...::.     .::|.|.|| ..:..:.|...|.|.|    |:|
  Rat   660 ---GLACDPFRSAGPG-ARADSGLRAFAPAVGSLLSEPAPA-ALAEEESPWICSDCGKTFGRRAA 719

  Fly   759 GSFFTAPAEDNLMLHRFMPRLHEFEAERGQPLKMRKSHSSAESSTS----------QKSHKGSSP 813
                       |..|:   |.|..|          :.|..|:...|          :::|.|..|
  Rat   720 -----------LAKHQ---RYHAGE----------RPHRCADCGKSFVYGSHLARHRRTHTGERP 760

  Fly   814 TPTPTASPGLTPSPSPPTSAGGELSS-----TSEGGAVPTMAAAAFAADHSALASGPTLPQTHPT 873
            .|.|......        :.|..|::     |.|...|..:..|.|:.            :.|.|
  Rat   761 FPCPECGARF--------ARGSHLAAHVRGHTGEKPFVCGVCGAGFSR------------RAHLT 805

  Fly   874 FHPLLLEEIYRSGFPFLCQPGGRR-GIEALLAGAASAAAPKRP--LPPVKFSAGSVVGLKTKDR- 934
            .|    ...:....|:.|...||| |..|.|.....|.|.::|  .|......|.....|...|
  Rat   806 AH----GRAHTGERPYACAECGRRFGQSAALTRHQWAHAEEKPHRCPDCGKGFGHSSDFKRHRRT 866

  Fly   935 ------YSCKFCGKVFPRSANLTRHLRTHTGEQPYPCKYCDRAFSISSNLQRHVRNIHNKERPFR 993
                  :.|..||:.|.:.:||.:|.|.||||:|:||..|.:.||..|.|..|.|. |..|||:.
  Rat   867 HTGEKPFRCADCGRGFAQRSNLAKHRRGHTGERPFPCPECGKRFSQRSVLVTHQRT-HTGERPYL 930

  Fly   994 CELCDRSFGQQTNLDRHVKKHESEGNNFRDSPSSSGIAERE 1034
            |..|.|.|.|.::|..|:|.|..:|.    :|:.:..|:.:
  Rat   931 CSNCGRRFSQSSHLLTHMKTHRGQGG----APAQNTSAKAQ 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ham	NP_724130.4	PR-SET_ZFPM	131..253	CDD:380978	29/139 (21%)
		C2H2 Zn finger	341..363	CDD:275368	8/21 (38%)
		C2H2 Zn finger	371..392	CDD:275368	6/20 (30%)
		SFP1	<391..479	CDD:227516	31/87 (36%)
		C2H2 Zn finger	400..421	CDD:275368	8/20 (40%)
		SUF4-like	403..>445	CDD:411020	17/41 (41%)
		C2H2 Zn finger	403..421	CDD:411020	7/17 (41%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	7/19 (37%)
		C2H2 Zn finger	486..504	CDD:275368	5/17 (29%)
		PTZ00121	<641..>728	CDD:173412	8/86 (9%)
		COG5048	935..>1028	CDD:227381	37/92 (40%)
		zf-C2H2	935..957	CDD:395048	8/21 (38%)
		C2H2 Zn finger	937..957	CDD:275368	8/19 (42%)
		zf-H2C2_2	949..973	CDD:404364	12/23 (52%)
		C2H2 Zn finger	965..986	CDD:275368	8/20 (40%)
		C2H2 Zn finger	994..1014	CDD:275368	8/19 (42%)
Zfp316	NP_001100591.1	KRAB	151..211	CDD:214630	11/63 (17%)
		KRAB	151..190	CDD:279668	6/38 (16%)
		COG5048	<335..495	CDD:227381	52/164 (32%)
		C2H2 Zn finger	339..359	CDD:275368	8/21 (38%)
		C2H2 Zn finger	367..387	CDD:275368	6/20 (30%)
		zf-C2H2	367..387	CDD:278523	6/20 (30%)
		zf-H2C2_2	379..404	CDD:290200	7/25 (28%)
		C2H2 Zn finger	395..415	CDD:275368	8/20 (40%)
		zf-H2C2_2	407..432	CDD:290200	10/25 (40%)
		C2H2 Zn finger	423..443	CDD:275368	9/19 (47%)
		zf-H2C2_2	435..460	CDD:290200	7/24 (29%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		zf-H2C2_2	463..486	CDD:290200	8/23 (35%)
		C2H2 Zn finger	479..497	CDD:275368	5/17 (29%)
		C2H2 Zn finger	707..727	CDD:275368	8/33 (24%)
		zf-H2C2_2	719..744	CDD:290200	9/48 (19%)
		C2H2 Zn finger	735..755	CDD:275368	2/19 (11%)
		zf-H2C2_2	747..772	CDD:290200	5/32 (16%)
		COG5048	<760..947	CDD:227381	60/211 (28%)
		C2H2 Zn finger	763..783	CDD:275368	3/27 (11%)
		zf-H2C2_2	775..800	CDD:290200	6/24 (25%)
		C2H2 Zn finger	791..811	CDD:275368	5/35 (14%)
		C2H2 Zn finger	819..839	CDD:275368	7/19 (37%)
		zf-C2H2	845..867	CDD:278523	4/21 (19%)
		C2H2 Zn finger	847..867	CDD:275368	4/19 (21%)
		zf-H2C2_2	859..884	CDD:290200	6/24 (25%)
		C2H2 Zn finger	875..895	CDD:275368	8/19 (42%)
		zf-H2C2_2	887..912	CDD:290200	13/24 (54%)
		C2H2 Zn finger	903..923	CDD:275368	8/20 (40%)
		zf-H2C2_2	916..940	CDD:290200	11/24 (46%)
		C2H2 Zn finger	931..951	CDD:275368	8/19 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000